EGFR kinases

There are very few reported studies outlining the use of homology modelling in protein kinases. Panigrahi and Desiraju [117] performed a simple comparison of a model of the EGFR kinase domain to an experimental... 

Pao, W., Miller, V. A., PoUti, K. A., et al. (2005) Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med. 2, e73. 

Gefitinib 2002 Non-small cell lung cancer EGFR kinase inhibitor [49]... 

MellinghofflK, Wang MY, Vivaneo I et al. Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors. NEnglJMed2005 353. 20 2-2024. 

Ji H, Li D, ChenL et al. The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies. Cancer Cell 2006 9 485 95. 

Residues of Glul27 and Glul70 are also shown and these are not conserved in the EGFR kinase. 

The microbial product staurosporine is a non.sclcciivepav tcin tyrosine kinase inhibitor uf EGFR kinase. A simpitt dianilinuphthalimide. analogue I. is a potent and sclcctlw inhibitor of EGFR kina.se.- ... 

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