Multimodal imaging

Fig. 8. Schematic representation of a pyrene-conjugated multimodality imaging probe prototype.

Fig. 31. Proposed design for core-shell multimodal imaging probes incorporating iron nanoparticles.

Fig. 34. Model of a functionalised (internally or externally) SWNT, which may be closed, open and/or corked reversibly or permanently after filling. Potentially the inner cavity may be filled with a (radio)-imaging agent (for PET/SPECT and/or MRI) or a (radio)therapeutic agent. Such functionalized SWNTs may conceivably act as probe prototype for multimodal imaging/therapy and targeted drug delivery (155).

The use of complementary, multimodal imaging techniques to analyze probes both in vivo and in vitro may be helpful in speeding up this process this should ensure that laboratory-based experiments mimic and are able to predict more closely the expected behavior of the probe in vivo. 

Wang S, Jarrett BR, Kauzlarich SM, Louie AY (2007) Core/Shell quantum dots with high relaxivity and photoluminescence for multimodality imaging. J Am Chem Soc 129 3848-3856... 

Another popular technique (particularly in medical applications) is the so called dual- or multimodal imaging , i.e., combined magnetic resonance (MRI) and... 

Degrassi A, Russo M, Nanni C et al (2010) Efficacy of PHA-848125, a cyclin-dependent kinase inhibitor, on the K-Ras(G12D)LA2 lung adenocarcinoma transgenic mouse model evaluation by multimodality imaging. Mol Cancer Ther 9 673-681... 

Valentino, D.J., Mazziota, J.C., Huang, H.K. (1991). Volume rendering of multimodal images Applications to MRI and PET imaging of the human brain. IEEE Trans. Med. Imaging 10,554-562. 

Louie A (2010) Multimodality imaging probes design and challenges. Chem Rev 110 3146... 

Fleming JS, Hashish AH, Conway JH, Nassim MA, Holgate ST, Halson P, et al. Assessment of deposition of inhaled aerosol in the respiratory tract of man using three-dimensional multimodality imaging and mathematical modeling. J Aerosol Med 1996 9(3) 317-327. 

Fleming JS, Halson P, Conway J, Moore E, Nassim MA, Hashish AH, et al.. Three-dimensional description of pulmonary deposition of inhaled aerosol using data from multimodality imaging. J Nucl Med 1996 37(5) 873-877. 

Expanding the Time Window for Intravenous Thrombolysis Patient Selection Based on Multimodal Imaging... 

Gold, magnetic, and semiconductor nanoparticles can also be useful probes in multimodal imaging techniques. Both glycobiology and glycobiophysics can profit from these biofunctional nano-tools. 

J. Kim, Y. Piao, and T. Hyeon, Multifunctional nanostructured materials for multimodal imaging, and simultaneous imaging and therapy, Chem. Soc. Rev., 38 (2009) 372-390. 

Nanoparticles were also assembled to enable multimodal imaging by loading different imaging contrast agents. For example, MRI-fluorescence imaging was... 

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