Lubricants sodium lauryl sulfate

Fig. 16 Effect of lubricant on dissolution of rate of salicylic acid contained in compressed tablets, x, 3% magnesium stearate , no lubricant 0> 3% sodium lauryl sulfate. (From Ref. 21.).

Soluble lubricants Adipic acid d, /-Leucine Glyceryl triacetate Magnesium lauryl sulfate PEG 400, 6000, and 8000 Polyoxyethylene monostearates Sodium benzoate Sodium lauryl sulfate Sucrose monolaurate Glidants... 

Ong et al. [134] found that several hydrophilic anionic, non ionic, or cationic surfactants can alleviate the deleterious effect of magnesium stearate over-mixing on dissolution from capsules when added with the lubricant in a ratio as low as 1 5 (w/w). These successful surfactants were sodium A-lauroyl sarcosinate, sodium stearoyl-2-lactylate, sodium stearate, polox-amer 188, cetylpyridinium chloride, and sodium lauryl sulfate. The lipophilic surfactant glyceryl monostearate did not alleviate the magnesium stearate mixing effect. A reduction in thier particle size was shown to enhance effectiveness, particularly in the case of surfactants with low solubility and slow dissolution rate. 

These are cleansing agents and decreases surface tension of dentrifrice. Most common detergent used in dentistry is sodium lauryl sulfate. They cause loosening of debris which adhere to teeth and also dissolving fatty substances and mucous plaques. They also act as an lubricant when scrubbed over the teeth. 

Surfactants such as sodium lauryl sulfate and magnesium lauryl sulfate also act as lubricants. 

Sodium lauryl sulfate 1-2 Water soluble, moderate lubricant, but good wetting properties, often employed in conjunction with stearates (Empicol , Stearowet C )... 

The water repellent properties of hydrocarbon based lubricants can be countered to a certain extent by the inclusion of a wetting agent such as sodium lauryl sulfate into the formulation. Such materials... 

Lubricants based on fatty acids, because of their low water solubility, are unsuitable for tablets which must be dissolved in water before use. Polyethylene glycol 6000 (macrogol 6000) is soluble in water, but its lubricant activity is limited. Magnesium lauryl sulfate has been suggested as a water-soluble substitute for magnesium stearate. In addition to its lubricant action, this substance, like sodium lauryl sulfate, is an effective wetting agent. ... 

Addition of wetting agents such as sodium lauryl sulfate or sodium docusate can assist this water penetration by lowering the surface tension, and they are often used in conjunction with hydrophobic lubricants such as magnesium stearate (see the article on Tablet Disintegrants and Disintegration in this encyclopedia). 

Magnesium stearate, talc, Compritol and sodium lauryl sulfate are some of the commonly used lubricants. Magnesium stearate and talc are water insoluble and water repellent. Their hydrophobic nature can lower the contact between the dosage form and GI fluids and thereby cause a slower dissolution. 

Figure 9.14 shows how magnesium stearate retards the dissolution of salicylic acid from tablets whereas tablets prepared using sodium lauryl sulfate (a soluble hydrophilic wetting agent) as a lubricant had rapid dissolution. 

Researchers also studied the effect of lubricants on dissolution rate of the active ingredient, which indicated that the more commonly used hydrophobic lubricants (magnesium stearate, aliuninum stearate, calcium stearate, glyceiyl monostearate, stearic acid) could decrease the effective drug-solvent interfacial area and thereby decrease the rate of dissolution of the drug, while water-soluble lubricants (sodiiun oleate, sodium lauryl sulfate, polyethylene glycol 4000 and talc) did not effect the dissolution rate [14, 15]. 

Lubricant substances which are reported in literature as suitable for effervescent manufacturing because they are water soluble are sodium benzoate, sodium acetate, L-leucine, and Carbowax 4000. A very recent application is a combination of calcium and potassium sorbates, micronized polyethylene glycol with calcium ascorbate or trisodium citrate (20). Combination of spray-dried L-leucine and polyethylene glycol 6000 has been reported as a successful lubricant in the literature (21). Other less soluble lubricants have been used in formulating effervescent tablets, however, a balance should be found between compression efficiency and water solubility. Magnesium stearate is also employed but the most suitable, commercially available type is its combination with sodium lauryl sulfate, a surface-active agent that helps in its dispersion (22). 

Sodium Lauryl Sulfate Anionic Surfactant, emulsif5dng agent, lubricant 1-2% 36-51... 

Chem. Descrip. Glyceryl stearate and sodium lauryl sulfate Uses Emollient, lubricant, solvent aux. emulsifier, stabilizer, emulsion thickener, opacifier In personal care prods. 

Lubricants To reduce the friction between the granules and the die wall during compression and ejection of the tableting process Water-insoluble metal stearates, stearic acid, talc Water-soluble boric acid, sodium chloride, benzoate and acetate, sodium or magnesium lauryl sulfate Carbowax 4000 or 6000... 

Sodium laureth-6 carboxylate detergent. It. duty cleaners Ammonium lauryl sulfate detergent, lubricants C12-14 pareth-8 C12-15 pareth-7 C13-15 pareth-20 C14-15 pareth-7 Disodium capryloamphodipropionate Lauroyl sarcosine Nonoxynol-60 PEG-1500 stearate Sodium cocoyl sarcosinate Sodium myristoyl sarcosinate... 

Cl2-14 pareth-9 DEA-lauryl sulfate Magnesium lauryl sulfate Sodium myristyl sulfate TEA-lauryl sulfate foam builder, lightweight concrete prod. Ammonium laureth sulfate foam builder, liq. cleaners heavy-duty Sodium cocoamphoacetate foam builder, liq. detergents TEA-dodecylbenzenesulfonate foam builder, liq. dishwashing Myristamide MEA foam builder, liq. hand soaps Potassium cocoate foam builder, liq. soaps Canolamidopropyl betaine Cocamidopropyl, betaine Palm kernelamide DEA foam builder. It. duty cleaners Ammonium lauryl sulfate foam builder. It. duty detergents Disodium PEG-4 cocamido MIPA sulfosuccinate foam builder, lubricants Sodium cocoyl sarcosinate Stearoyl sarcosine... 

PEG-6 stearate PEG-7 stearate PEG-35 stearate PEG-90 stearate PEG-4 tallate PEG-20 tallate PEG-2 tallowate Sodium lauroyl sarcosinate Sorbitan trioleate Sulfated butyl tallate Trioctyl phosphate Triolein lubricant, leather auxiliaries Dihydrogenated tallow phthalate Lauryl phosphate... 

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