Carcinoma papillary transitional cell

In hamsters, 0.3% DCB in the diet produced transitional cell carcinomas of the bladder and some liver cell tumors. Liver tumors were also found in mice exposed to DCB. Female dogs fed 8mg/kg/day for a period of 6-7 years had hepatocellular carcinomas and papillary transitional cell carcinomas of the urinary bladder tumors were absent in untreated controls. ... 

Four of four beagle dogs administered DCB by capsule for 7 years had bladder papillary transitional cell carcinoma and three had liver carcinoma untreated controls had no liver or bladder neoplasms. ... 

MOCA was fed to male and female mice for 18 months at a dose of either 1 or 2 g/kg in female mice, but not in males, a statistically significant incidence of hepatoma was observed. In addition, a higher incidence of hemangiosarcomas and hemangiomas was observed in treated animals compared with controls. Urinary bladder tumors (primarily papillary transitional cell carcinomas) occurred in dogs given 100 mg of MOCA by capsule for up to 9.0 years. ... 

Theodorescu, D., Comil, I., Sheehan, C., Man, M. S. and Kerbel, R. S. (1991a) Haras induction of the invasive phenotype results in upregulation of epidermal growth factor receptors and altered responsiveness to epidermal growth factor in human papillary transitional cell carcinoma cell. Cancer Res. 51, 4475-4491. 

Moderate atypia and atypical hyperplasia of the urothelium were first described in 4 pieces of nephroureterectomies performed in 3 CHN patients prior or at time of transplantation [28]. Then, three cases of cancers of the urinary tract were reported the first case, a 28 year old woman with CHN, developed two papillary transitional cell carcinomas in the posterior bladder wall 12 months after a renal transplantation [31] the second case, a 42 year old woman with CHN, presented with hematuria secondary to a papillary transitional cell carcinoma of the right pelvis [32]. The third case was a 49 year old woman previously published as... 

Adenocarcinoma of breast, colon, biliary tract, pancreas, lung, ovary, skin papillary transitional cell carcinoma of bladder, anaplastic large cell lymphoma, diffuse large B-cell lymphoma... 

In monkeys, intragastric administration of 37-2400mg/kg/week for up to 250 weeks caused nine transitional cell carcinomas of the bladder and three papillary adenomas. ... 

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