Quantitation high throughput

Ackermann, B.L., Michael, J., Berna, MJ. et al. (2002) Recent advances in use of LC/MS/MS for quantitative high-throughput bioanalytical support of drug discovery. Current Topics in Medicinal Chemistry, 2, 53-66. 

The development of quantitative high-throughput screening (qHTS) paradigms that provide concentration-response curves for large chemical libraries in a... 

G. Hopfgartner and E. Bourgogne. Quantitative High-Throughput Analysis of Drugs in Biological Matrices by Mass Spectrometry. Mass Spectrom. Rev., 22(2003) 195 -214. 

In general, flow cytometry is an optical analytical method to characterize cells or particles in suspension. Accordingly, a flow cytometer is simply described as a specialized fluorescence microscope equipped with a quantitative high-throughput detector system to measure various cellular parameters [33-35],... 

Mastyugin, V., McWhinnie, E., Labow, M., and Buxton, F., A quantitative high-throughput endothelial cell migration assay, ]. Biomol. Screen., 9, 712, 2004. 

Hopfgartner, G. Bourgogne, E. Quantitative high-throughput analysis of dmgs in biological matrices by mass spectrometry. Mass Spectrom. 

MaUakal JC (2002) Quantitative high throughput endotheUal ceU migration and invasion assay system. Methods Enzymol 352 175-182... 

Meneses-Lorente, G., Sakatis, M.Z., Schulz-Utermoehl, T., De Nardi, C. and Watt, A.P. (2006) A quantitative high-throughput trapping assay as a measurement of potential for bioactivation. Analytical Biochemistry, 351 (2), 266-272. 

The combination of bisulfate treatment and MassCLEAVE makes MALDI-TOF MS a quantitative, high throughput DNA methylation analysis tool that will be useful in future epigenetic research efforts. 

Inglese, J. et al. 2006. Quantitative high-throughput screening a titration-based approach that efficiently identifies biological activities in large chemical libraries. Proc. Natl. Acad. Sci. USA 103, 11473-11478. 

Xia, M. et al. 2008. Compound cytotoxicity profiling using quantitative high-throughput screening. Envir. Health Perspect. 116, 284—291. 

Xia M, Huang R, Witt KL, Southall N, Fostel J, Cho MH, Jadhav A, Smith CS, Inglese J, Portier CJ, Tice RR, Austin CP. Compound cytotoxicity profiling using quantitative high throughput screening. Environ. Health Perspect. 2008 116 284-291. 

Austin CP, Inglese J, Simeonov A. Compound management for quantitative high-throughput screening. J. Assoc. Lab. Automat. 2008 13 79-89. 

CP, Sidransky E. Three classes of glucocerebrosidase inhibitors 48. identified by quantitative high-throughput screening are chaperone leads for Gaucher disease. Proc. Natl. Acad. Sci. U.S.A. 2007 104 13192-13197. 

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