High temperature liquid chromatography

Renn, C. N. and Synovec, R. E., Refractive index gradient detection of biopolymers separated by high-temperature liquid chromatography, /. Chromatogr., 536, 289, 1991. 

Applications High-temperature liquid chromatography with packed-capillary columns, nonaqueous mobile phases, and ELSD and ICP-MS detection, has been developed specifically as a robust analytical tool for the analysis of high-MW polymer additives [731,738]. Dissolving such moderately polar, heavy compounds with low water solubility at ambient temperature usually... 

R. Trones, Development of Packed Capillary High Temperature Liquid Chromatography Utilizing Light Scattering and Inductively Coupled Plasma Mass Spectrometry Detection, PhD. Thesis, University of Oslo (1999). 

Greibrokk, T. and Andersen, T., High-temperature liquid chromatography. Journal of Chromatography A 1000(1-2), 743-755, 2003. 

Trones, R., Tangen, A., Lund, W., and Greibrokk, T., Packed capillary high-temperature liquid chromatography coupled to inductively coupled plasma mass spectrometry. Journal of Chromatography A 835(1-2), 105-112, 1999. 

J. D. Thompson and P. W. Carr, A study of the critical criteria for analyte stability in high-temperature liquid chromatography, ArzaZ. Chem. 74 (2002), 1017-1023. 

S. J. Marin, B. A. Jones, W. D. Felix, and J. Clark, Effect of high-temperature on high-temperature liquid chromatography column stability and performance under temperature-programmed conditions,/. Chromatogr. A 1030 (2004), 255-262. 

High Temperature Liquid Chromatography A User s Guide for Method... 

Trones, R., Iveland, A. and Greibrokk, T. (1995) High temperature liquid chromatography on packed capillary columns with nonaqueous mobile phases. J. Microcol. Sep., 1, 505-12. 

During the last few years, other methods for PO microstructure analysis have been proposed. Of these, the high-temperature liquid chromatography (HTLC) is the most promising. Using two sets of columns, one may fractionate the polymer according to composition (TREF part) and then MW (SEC part) or vice versa. 

The possibilities for influencing the viscosity of the mobile phase are limited. Working at higher temperatures can be an advantage in some cases (e.g., high-temperature liquid chromatography). 

Roy A, Miller MD, Meunier DM, Degroot AW, IMnniford WL, Van Damme FA, et al. Development of comprehensive two-dimensional high temperature liquid chromatography X gel permeation chromatography for characterization of polyolefins. Macromol 2010 43 3710-20. 

Another most exciting new tool for the analysis of complex polyolefins is the direct coupling of high-temperature liquid chromatography and H-NMR. Such equipment became available only recently when a high-temperature flow-through NMR probe was introduced by Bruker. The construction and experimental setup of the LC-NMR coupling is described in detail by Hiller et al. [130]. In brief, the NMR flow probe can operate at temperatures up to 150°C. The probe has an active flow cell with a volume of 120 pL. It is a dual inverse H/ C probe with pulse field... 

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