Lipopolysaccharide-induced tumor necrosis factor

A2. Aderka, D., Le, J., and Vilcek, J., IL-6 inhibits lipopolysaccharide-induced tumor necrosis factor production in cultured human monocytes U937 cells, and in mice. J. Immunol. 143, 3517-352) (1989). 

Elenkov, IJ. et al., Modulation of lipopolysaccharide-induced tumor necrosis factor-a production by selective a- and P-adrenergic drugs in mice, J. Neuroimmunol., 61, 123, 1995. 

Marier JF, Chen K, Prince P, Scott G, del Castillo JR, Vachon P. 2005. Production of ex vivo lipopolysaccharide-induced tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6 is suppressed by /ran.v-rcsvcratrol in a concentration-dependent manner. Can J Vet Res 69 151-154. 

Lipopolysaccharide-induced tumor necrosis factor is encoded on a gene... 

Dentener, M.A., Bazil, U, Von Asmuth, E.J., Ceska, M. and Buurman, W.A. (1993). Involvement of CD14 in lipopolysaccharide-induced tumor necrosis factor-alpha, IL-6 and IL-8 release by human monocytes and alveolar macrophages. J. Immunol. 150, 2885-2891. 

Mathison JC, Virca GD, Wolfson E, Tobias PS, Glaser K, Ulevitch RJ. 1990. Adaptation to bacterial lipopolysaccharide controls lipopolysaccharide-induced tumor necrosis factor production in rabbit macrophages. J. Clin. Invest. 85 1108-18... 

Modulation of lipopolysaccharide-induced tumor necrosis factor-alpha and nitric oxide production by dopamine receptor agonists and antagonists in mice. Immunol. Lett., 49,143-147. 

Nelson S, Bagby GJ, Bainton B, Wilson LA, Thompson JJ, Summer WR. Compartmentalization of intraalveolar and systemic lipopolysaccharide-induced tumor necrosis factor and the pulmonary inflammatory response. J Infect Dis 1989 159 189-194. 

Baumgartner, J.D., Heumann, D., Gerain, J., Weinbreck, P., Grau, G.E., Glauser, M.P. Association between protective efficacy of anti-lipopolysaccharide (LPS) antibodies and suppression of LPS-induced Tumor necrosis factor a and interleukin 6. Comparison of O side chain-specific antibodies with core LPS antibodies. J Exp Med 171 (1990) 889-896. 

Fig.l. Effects of various fatty acids on lipopolysaccharide (LPS)-induced tumor necrosis-factor (TNF)-a production. THP-1 cells preincubated with 60 iM of docosahexaenoic acid (DL), eicosa-pentaenoic acid (EL), arachidonic acid (AL), oleic acid (OL) or stearic acid (SL) for 24 h were stimulated with LPS for 6 h. The amount of TNF-a produced in the control LPS-stimulated cells (L) is set as 100%. TNF-a levels in cell culture supernatant were determined by enzyme-linked immunosorbent assay. Values are means SEM, n = 3. Significantly different from control group (P< 0.05). 

Abbreviations AIA, adjuvant-induced arthritis CIA, collagen-induced arthritis IL, interleukin ENA, Epithelial-neutrophil activating protein MIP, macrophage inflammatory protein MCP, monocyte chemoattractant protein EPS, lipopolysaccharide TNF, tumor necrosis factor IFN, interferon TGF, transforming growth factor IL-1 Ra, interleukin-1 receptor antagonist OSM, Oncostatin M. 

C14. Chaudhri, G and Clark, I. A., Reactive oxygen species facilitate the in vitro and in vivo lipopolysaccharide-induced release of tumor necrosis factor. J. Immunol. 143, 1290-1294... 

M16. Mathison, J. C., Wolfson, E., and Ulevitch, R. J., Participation of tumor necrosis factor in the mediation of gram-negative bacterial lipopolysaccharide-induced injury in rabbits. J. Clin. Invest. 81, 11925-11937(1988). 

Z8. Zuckerman, S. H., Shellhaas, J., and Butler, L. D., Differential regulation of lipopolysaccharide-induced interleukin I and tumor necrosis factor synthesis Effects of endogenous and exogenous glucocorticoids and the role of the pituitary-adrenal axis. Eur. J. Immunol. 19,301-305 (1989). 

Recently, the possibility to use C60 as anti-inflammatory compound has been reported (Huang et al., 2008). Fullerene-xanthine hybrids have been studied to determine if nitric oxide (NO) and tumor necrosis factor-alpha (TNF-a) production in lipopolysaccharide (LPS)-activated macrophages can be inhibited by hybrid administration, finding positive results. The presence of xanthine moiety seems to be essential for the inhibition of LPS-induced TNF-a production, while the fullerene portion ameliorates the efficiency in LPS-induced NO production blockage, leading to a new promising class of potent anti-inflammatoiy agents. It is necessary to mention also the opposite results obtained by an amino acid fullerene derivative tested on human epidermal keratinocytes at concentration from 0.4 to 400 pg/mL. 

Azab, A., Fraifeld, V., Kaplanski, J. Nimesulide prevents lipopolysaccharide-induced elevation in plasma tumor necrosis factor-alpha in rats, Life Sci. 1998, 63, PL 323-327. 

Stokes, D.C., Shenep, J.L., Fishman, M.L., Hidner, W.K., Bysani, G.K., Rufus, K. Polymyxin B prevents lipopolysaccharide-induced release of tumor necrosis factor-a from alveolar macrophages. J Infect Dis 160 (1989) 52-57. 

Ohlsson, B.C., Englund, M.C., Karlsson, A.L., Knutsen, E., Erixon, C, Skribeck, H., Liu, Y., Bondjers, G., and Wiklund, O., 1996, Oxidized low density lipoprotein inhibits lipopolysaccharide-induced binding of nuclear factor-kappaB to DNA and the subsequent expression of tumor necrosis factor-alpha and interleukin-1 beta in macrophages, J. Clin. Invest. 98 78-89. 

BH4 = Tetrahydrobiopterin CAM = Cytotoxic activated macrophage cNOS = Constitutive nitric oxide synthase CPR = Cytochrome P450 reductase EDRF = Endothelial-derived relaxation factor EPR = Electron paramagnetic resonance spectroscopy IL-1 = Interleukin-1 iNOS = Inducible nitric oxide synthase EPS = Lipopolysaccharide, or endotoxin NMMA = ISp-monomethyl-L-arginine NOS = Nitric oxide synthase ROS = Reactive oxygen species SOD = Superoxide dismutase TNF = Tumor necrosis factor. 

Hoover, D.L., Friedlander, A.M., Rogers, L.C., Yoon, I.K., Warren, R.L., Cross, A.S. (1994). Anthrax edema toxin differentially regulates lipopolysaccharide-induced monocyte production of tumor necrosis factor a and interleukin-6 by increasing intracellular cyclic AMP. Infect. Immun. 62 4432-9. 

Heptadepsin (Fig.25) was discovered by Ohno et al. in 2004 from Paenibacillus sp. during screening for inhibition of lipopolysaccharide (LPS)-stimulated adhesioin between human umbilical vein endothelial cells and human myelocytic HL-60 cells. Heptadepsin inhibits cell adhesion induced by either LPS or lipid A by direct interaction with LPS, but does not inhibit tumor necrosis factor-a or IL-lp-induced cell adhesion ... 

M. (2001) Lipopolysaccharide-induced apoptosis of macrophages determines the up-regulation of concentrative nucleoside transporters Cntl and Cnt2 through tumor necrosis factor-alpha-dependent and -independent mechanisms. The Journal of Biological Chemistry, 276 (32), 30043-30049. 

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