Cytotoxic activated macrophages

I IS. Hibbs-. B, Taintor, R. R., Vavrm, Z., and Rachlin, E. M. (1988). Nitric oxide A cytotoxic activated macrophage effector molecule. Biochem. Biophys. Res. Commun. 1.57, 87-99,... 

Catectin promotes tumor cytotoxicity activates macrophages and neutrophils enhances IL-2 receptor expression on T cells inhibits antibody secretion... 

Jones, 1971), and it is now known that these cytotoxic activated macrophages (CAMs) can be formed in vitro from macrophages by a combination of two signals, usually interferon-y and lipopolysaccharide (a major component of the cell wall of gram-negative bacteria). 

Drapier, J. C., and Hibbs, J. B., Jr. (1986). Murine cytotoxic activated macrophages inhibit aconitase in tumor cells. Inhibition involves the iron-sulfur prosthetic group and is reversible. J. Clin. Invest. 78, 790-797. 

Lancaster, J. R., and Hibbs, J. B. (1990). EPR demonstration of iron-nitrosyl complex formation by cytotoxic activated macrophages. Proc. Natl. Acad. Sci. LJ.S.A. 87, 1223-1227. 

Cell-Mediated Immunity, Cytotoxic Activated Macrophages, and Cytokines 5... 

Cytotoxic activated macrophages (CAMs) macrophages that have been treated either in vivo or in vitro by exposme to a combination of bacterial products (such as endotoxin) plus cytokines (particularly interferon-y), rendering them able to kill or damage abnormal cells (cancerous or infected with pathogenic microbe or vims) or pathogen. An important component of the CAMs armamature for this cytotoxic mechanism is production of -NO... 

BH4 = Tetrahydrobiopterin CAM = Cytotoxic activated macrophage cNOS = Constitutive nitric oxide synthase CPR = Cytochrome P450 reductase EDRF = Endothelial-derived relaxation factor EPR = Electron paramagnetic resonance spectroscopy IL-1 = Interleukin-1 iNOS = Inducible nitric oxide synthase EPS = Lipopolysaccharide, or endotoxin NMMA = ISp-monomethyl-L-arginine NOS = Nitric oxide synthase ROS = Reactive oxygen species SOD = Superoxide dismutase TNF = Tumor necrosis factor. 

CELL-MEDIATED IMMUNITY, CYTOTOXIC ACTIVATED MACROPHAGES, AND CYTOKINES... 

What are the specific intracellular derangements that occur in target cells (specifically, tumor cells) in response to activated macrophages In 1980, Krahenbuhl studied the in vitro (in culture) effects of murine cytotoxic activated macrophages (CAMS, produced by injection of killed C. parvum) on EMT-... 

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