Effect on synthesis

Effects on Synthesis, Storage, Release, Transport and Clearance of Hormones... 

An acceleration of protein turnover by thyroxine also has been shown, implying that the hormone may alter various processes by a specific effect on synthesis of certain key proteins Involved in enzymatic reactions, Thus, not only does thyroxine increase the rate of formation of new protein material, hut it also may be responsible for the transformation of non-en/.ymalically active protein Into protein with enzymatic activity. The hormone has also been shown to be capable of acceleration of the synthesis of urea cycle enzymes and probably is essential for the production of a... 

In perfused liver it also has effects on synthesis of most types of RNA and on amino acid uptake, and these may underlie much of the action on protein synthesis. For most effects on the liver there appears to be a delay of 15-60 min between the application of hormone and the first manifestation of the effect. Ribosomes from liver of hypophysectomized rats possess a lowered ability to carry out protein synthesis [86] and the defect can be reversed by administration of GH in vivo or in vitro. The effect may be at least partly on the rate of elongation of the growing polypeptide chain [85]. 

In addition to its effects on synthesis of milk proteins themselves, prolactin also induces the production in the mammary gland of other proteins/enzymes involved in production of milk components. Lactose synthetase and enzymes of lipid metabolism, including acetyl-CoA carboxylase and lipoprotein lipase, are among these inducible enzymes [75]. 

G. Site Density and Pellet Size Effects on Synthesis Selectivity... 

Corticosteroid Effects. Glucocorticoids, such as cortisol (endogenous) and dexamethasone (exogenous), and androgens are associated with increased synthesis of Hp and secondarily elevated plasma levels. Dexamethasone acts, at least in vitro, by enhancing the response of synthesis to interleukins rather than by a direct effect on synthesis. 

A polar effect on synthesis of mRNA was observed. If the five... 

Liver dysfunction (effects on synthesis and secretion of vitamin K-dependent factors)... 

Malinger, K.A., Ding, Y.-S., Sithambaram, S., Espinal, L., Gomez, S., and Suib, S.L. 2006. Microwave frequency effects on synthesis of cryptomelane-type manganese oxide and catalytic activity of cryptomelane precursor. Journal of Catalysis 239, 290-298. 

Because of the high prevalence of coronary artery disease in patients with heart failure, aspirin frequently is coadministered with ACE inhibitors. Several retrospective cohort analyses snggest that aspirin may attenuate the hemodynamic and mortality benefits of ACE inhibitors. The postulated mechanism of this interaction involves opposing effects on synthesis of vasodilatory prostaglandins. The ACE inhibitor-mediated increase in bradykinin increases the synthesis of vasodilatory prostaglandins that have favorable hemodynamic benefits in heart failure. Because of aspirin s effect... 

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