Laser desorption/ionization mass spectrometry overview

This review provides an up-to-date overview of the application of analytical procedures based on MS for the characterization of organic natural materials in archaeological and historical objects. Applications that feature the use of gas chromatography/mass spectrometry (GC/MS), Py-GC/MS, high performance liquid chromatography combined with mass spectrometry (HPLC/MS), and direct MS analysis such as matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS), electrospray ionization mass spectrometry (ESI-MS), and direct exposure mass spectrometry (DE-MS) are sununarized to highlight the different information provided by each of the various analytical approaches. Case studies and examples are also presented and include a description of the molecular markers and of the molecular profiles that are used to identify the original materials. 

Jagtap, R. Ambre, A. Overview literature on matrix assisted laser desorption ionization mass spectrometry (MALDI MS) Basics and its applications in characterizing polymeric materials. Bull. Mater. Sci. 2005, 28, 515-528. 

Dmbach, P. Matrix-assisted laser desorption-ionization mass spectrometry An overview. Spectroscopy 1998, 13, 16-27. 

See alsa Drug Metabolism Metabolite Isolation and Identification Isotope Studies. Liquid Chromatography Liquid Chromatography-Mass Spectrometry. Mass Spectrometry Ionization Methods Overview Matrix-Assisted Laser Desorption Ionization Mass Separation ... 

Most of the mass spectrometry applications for combinatorial chemistry will be described in the following sections of this chapter. Here we will give a short overview of MS techniques utilized for the characterization of resin-bound molecules. The majority of publications in this field describe applications of matrix-assisted laser desorption ionization (MALDI), combined with time-of-flight (TOF) detection. The major difference of MS application for analysis of resin-bound molecules from the above-described NMR and IR applications is that analyte should not be covalently bound to solid support prior to mass measurement. Detachment of compound molecules from resin can be done chemically (for example, by bead exposure to TFA vapors) [30,31] or photochemically, such that cleavage, desorption, and ionization of molecules occur simultaneously upon stimulation by laser radiation [32], Since the... 

See also Capillary Electrophoresis Overview. Electrophoresis Principles Isotachophoresis Isoelectric Focusing Polyacrylamide Gels Two-Dimensional Gels Affinity Techniques Blotting Techniques Clinical Applications. Mass Spectrometry Overview Matrix-Assisted Laser Desorption Ionization Time-of-Flight. 

See also Mass Spectrometry Overview Ionization Methods Overview Eiectron Impact and Chemical Ionization Atmospheric Pressure Ionization Techniques Electrospray Liquid Secondary Ion Mass Spectrometry Matrix-Assisted Laser Desorption/lonization Mass Separation Ion Traps Time-of-Flight. 

See also Carbohydrates Overview. Elemental Speciation Overview. Food and Nutritional Analysis Overview. Gas Chromatography Mass Spectrometry. Lipids Overview. Liquid Chromatography Liquid Chromatography-Mass Spectrometry Food Applications. Mass Spectrometry Overview Principles Ionization Methods Overview Atmospheric Pressure Ionization Techniques Eiectrospray Matrix-Assisted Laser Desorption/lonization Pyrolysis. Proteins Traditional Methods of Sequence Determination. Vitamins Overview. 

See also Bioassays Overview. Capillary Electrophoresis Overview. Electrophoresis Oven/iew Principles Two-Dimensional Gels. Gas Chromatography Overview Mass Spectrometry. Immunoassays Overview. Immunoassays, Applications Food. Immunoassays, Techniques Radioimmunoassays Enzyme Immunoassays. Liquid Chromatography Reversed Phase Liquid Chromatography-Mass Spectrometry Food Applications. Mass Spectrometry Oven/iew Principles Matrix-Assisted Laser Desorption Ionization Time-of-Flight. Radiochemical Methods Radioreceptor Assays Food and Environmental Applications. Thin-Layer Chromatography Oven/iew. 

Chapter 6, titled Selection of Ionization Methods of Analytes in the TLC-MS Techniques provides an overview of mass spectrometric techniques that can be coupled with TLC and act as specific detectors in this hyphenated approach. The mass spectrometric techniques discussed in this chapter are secondary mass spectrometry (SIMS), liquid secondary ion mass spectrometry (LSIMS), fast atom bombardment (FAB), matrix-assisted laser desorption/ionization (MALDI), atmospheric pressure matrix-assisted laser desorption/ionization (AP-MALDI), electrospray ionization (ESI), desorption electrospray ionization (DESI), electrospry-assisted laser desorption/ionization (ELDI), easy ambient sonic spray ionization (EASI), direct analysis in real time (DART), laser-induced acoustic desorption/electrospray ionization (LIAD/ESI), plasma-assisted multiwavelength laser desorption/ionization (PAMLDI), atmospheric-pressure chemical ionization (APCI), and dielectric barrier discharge ionization (DBDI). For the sake of illustration, the authors introduce practical examples of implementing TLC separations with detection carried out by means of individual mass spectrometric techniques for the systematically arranged compounds belonging to different chemical classes. 

See also Mass Spectrometry Ionization Methods Overview Atmospheric Pressure Ionization Techniques Electrospray Matrix-Assisted Laser Desorption/lonization Time-of-Fiight. Proteins Traditionai Methods of Sequence Determination. Proteomics. 

See also Surface Analysis Overview X-Ray Photoelectron Spectroscopy Auger Electron Spectroscopy Desorption Techniques Ion Scattering Secondary Ion Mass Spectrometry of Polymers Laser Ionization. 

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