Radioreceptor assays

Eiizyme-Iinked immunosorbent assay Radioimmunoassay Immunoradiometric assay Radioreceptor assay... [Pg.482]

Houssler, M. R. "Radioreceptor Assay for la25-Dlhydroxy-vitamin D3". Science (1973), 183, 1089-1091. [Pg.56]

The purpose of these studies was to determine whether stereotyped behavior and ataxia induced by PCP-like drugs and sigma opioids is mediated by PCP receptors. Also, we wanted to investigate whether sigma opioid and PCP receptors are the same receptors using behavioral and radioreceptor assays. [Pg.94]

Saleh MA, Abou Zied M, El-Baroty G, et al. 1993. Gamma aminobutyric acid radioreceptor-assay, a possible biomarker for human exposure to certain agrochemicals. J Environ Sci Health B28 687-699. [Pg.187]

Janssen, M.J., Ensing, K., de Zeeuw, R.A. Improved benzodiazepine radioreceptor assay using the Multiscreen assay system. [Pg.281]

TABLE 1-7. Antipsychotic ieveis by gas-liquid chromatography and radioreceptor assay ... [Pg.19]

Javaid Jl, Pandey GN, Duslak B, et al. Measurement of neuroleptic concentrations by GLC and radioreceptor assay. Common Psychopharmacol 1980 4 467-475. [Pg.21]

Inadequate assay methods, such as radioreceptor assays... [Pg.73]

Smith RC, Baumgartner R, Misra CH, et al. Haloperidol. Plasma levels and prolactin response as predictors of clinical improvement in schizophrenia. Chemical versus radioreceptor plasma level assays. Arch Gen Psychiatry 1984 41 1044-1049. [Pg.97]

Rimon R, Averbuch I, Rozick P, et al. Serum and CSF levels of haloperidol by radioimmunoassay and radioreceptor assay during high-dose therapy of resistant schizophrenic patients. Psychopharmacology 1981 73 197-199. [Pg.97]

Timolol concentration in plasma and tear fluid samples was measured using a modified radioreceptor assay [7]. In the assay, displacement of a P-antagonist, (-)-3H-CGP-12177, from 0-receptors of rat reticulocyte membranes by timolol was measured. Rat reticulocyte membranes were obtained as described by Wellstein el al. [7]. [Pg.157]

A.Wellstein, D.Palm, G.Wiemer, M.Schafer-Korting and E.Mutschler, Simple and reliable radioreceptor assay for beta-adrenoceptor antagonists and active metabolites in native human plasma, Eur. J. Clin. Pharmacol, 27, 545 (1984). [Pg.160]

Benzodiazepines are an important group of drugs with tranquilizing properties. Available immunochemical methods include radioimmunoassays (164, 165), a radioreceptor assay (166), and nonseparation immunoassays such as the widely used enzyme-monitored immunotest (EMIT) and fluorescent polarization immunoassays (167, 168). Such assays generally require sophisticated apparatus and dedicated laboratories. However, a relatively simple enzyme-linked immunosorbent assay was recently described for screening benzodiazepines in urine (169). [Pg.865]

L.E. Llewellyn, A.P. Negri, J. Doyle, P.D. Baker, E.C. Beltran and B.A. Neilan, Radioreceptor assays for sensitive detection and quantitation of saxitoxin and its analogues from strains of the freshwater cyanobacterium, Anabaena circinalis, Environ. Sci. Technol., 35 (2001) 1445-1451. [Pg.352]

Aaltonen L, Kanto J, Iisalo E, Pihlajamaki K (1984) Comparison of radioreceptor assay and radioimmunoassay for atropine pharmacokinetic application. Eur J Clin Pharmacol 26 613-617... [Pg.343]

Gelato MC, Merriam GR (1986) Growth hormone releasing hormone. Ann Rev Physiol 48 569-591 Halmos G, Rekasi Z, Szoke B, Schally AV (1993) Use of radioreceptor assay and cell superfusion system for in vitro screening of analogs of growth hormone-releasing hormone. Receptor 3 87-97... [Pg.341]

Cheng KW (1975) A radioreceptor assay for follicle-stimulating hormone. J Clin Endocrin Metab 41 581-589 Foulds LM, Robertson DM (1983) Electrofocusing fractionation and characterization of pituitary follicle-stimulating hormone from male and female rats. Mol Cell Endocrinol 31 117-130... [Pg.348]

The article concluded HPLC has now become an important analytical tool to determine structure and purity and is now considered to be a more precise measurement of potency than the rabbit assay, although most government regulatory agencies around the world still emphasize the rabbit potency assay.. .. In the end, we employed 12 different tests to establish that what we had produced was human insulin. We believe that correlation among three of the tests was particularly important—the radioreceptor assay, radioimmunoassay, and HPLC. ... [Pg.29]

Nishikawa T, Suzuki S, Ohtani H, Eizawa NW, Sugiyama T, Kawaguchi T, Miura S. Benzodiazepine concentrations in sera determined by radioreceptor assay for therapeutic-dose recipients. Am J Clin Pathol 1994 102(5) 605-10. [Pg.413]

The properties of membranes can also be used for analytical purposes. A radioreceptor assay for somatomalin A has been developed using human placental membrane. This assay is more sensitive and simpler than the chick bioassay and requires only 40 pi of serum. It is not species-specific... [Pg.205]

Charcoal is widely used to separate antibody-bound ligand (bound) from non-antibody-bound ligand (free) in competitive protein binding assays. Its use was originally described by Miller for vitamin Bi assay and later by Herbert et al. for B12. In 1965, Herbert suggested its use to separate bound and free in the radioimmunoassay of insulin. Since then it has been used for a large number of radioimmunoassays and radioreceptor assays. [Pg.274]

The optimal RIA parameters of the talc-resin-TCA test also apply to iodohormones used in bioassays and radioreceptor assays (RRA). The talc and TCA testing has been used to monitor the degradation of I-la-beled hormone used with prolactin, insulin, and growth hormone receptors. Strict adherence to the limits of >90% talc adsorption, <25% resin binding, and >90% TCA precipitation provides a rigorous quality control for the presence of bioactive and receptor-affinitive monomeric iodohormone. [Pg.334]

The work with atropine presents a confusing picture. Use of racemic radioligand in these studies may contribute to the observed cross-reactivity picture. The rather facile enolization and hence racemization of atropine-type structures is another problem. FinaUy, the structure of the product of atropine and diazotized p-aminobenzoic acid has never been established conclusively. For these reasons, the radioreceptor assay for this compound (see below) is generally preferable. [Pg.48]

K. Ensing and R, A. deZeeuw, Radioreceptor assay—A tool for the bioanalysis of drugs. Trends Anal. Chem., 3 102-106 (1984). [Pg.64]

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