Mass spectrometry tandem techniques

New cumulenic ions, S=N=C=C=0+ and S=N=C=C=S+, have been generated by dissociative ionization and characterized by tandem mass spectrometry techniques starting from 1,2,5-thiadiazole-3,4-dicarboxamide 29 and 3-cyano-l,2,5-thiadiazole-4-thiocarboxamide 30 respectively (Scheme 2) <1996JPC10536>. 

Sulfatide in urine can be quantified by high-performance liquid chromatography (HPLC) [39] and tandem mass spectrometry techniques [63]. Here, a simple semi-quantitative thin-layer chromatography (TLC) method is described, as modified from Rail et al. [46]. 

Dongre, A.R., Eng, J.K., Yates, J.R. Ill (1997) Emerging tandem-mass-spectrometry techniques for the rapid identification of proteins. Trends Biotechnol. 15, 418-425. 

Guided beam tandem mass spectrometry techniques have been used to examine the promotion of the 5n2 reaction... 

Sauvage FL, Gaulier JM, Lachatre G et al (2006) A fully automated turbulent-flow liquid chromatography-tandem mass spectrometry technique for monitoring antidepressants in human serum. Ther Drug Monit 28 123-130... 

Collision-induced dissociation of protonated indole with Xe has been studied as a function of kinetic energy using guided ion beam tandem mass spectrometry techniques <2007MI388>. 

These extraction procedures do not require a purification step when analysis is performed by a liquid or gas chromatographic system coupled with a tandem mass spectrometry technique (LC-MS/MS and GC-MS/MS). 

JD Gilbert, TV Olah, MJ Morris, A Bortnick, J Brunner. The use of stable isotope labeling and liquid chromatography-tandem mass spectrometry techniques to simultaneously determine oral and ophthalmic bioavailability of timolol in dogs. J Chromatogr Sci 36 163—168, 1998. 

Chu I, Liu F, Soares A, Kumari P, Nomeir AA. Generic fast gradient liquid chromatography/ tandem mass spectrometry techniques for the assessment of the in vitro permeability across the blood-brain barrier in drug discovery Rapid Common Mass Spectrom 2002 16(15) 1501-1505. 

Fang SP, Hao CY, Liu ZQ, Song FR, Liu SY (1999) Application of Electrospray Ionization Mass Spectrometry Combined with Sequential Tandem Mass Spectrometry Techniques for the Profiling of Steroidal Saponin Mixture Extracted from Tribulus terrestris. Planta Med 65 68... 

Barrish, A. et al.. The use of stable isotope labehng and liquid chromatography/tandem mass spectrometry techniques to study the pharmacokinetics and bioavadability of the antimigraine drug, MK-0462 (rizatriptan) in dogs. Rapid Commun. Mass Spectrum., 10 1033-1037, 1996. 

Mohamed R, Hammel YA, LeBreton MH, Tabet JC, Jullien L, Guy PA, Evaluation of atmospheric pressure ionization interfaces for quantitative measurement of sulfonamides in honey using isotope dilution liquid chromatography coupled with tandem mass spectrometry techniques, J. Chromatogr. A 2007 1160(l-2) 194-205. 

Facino, R.M., Carini, M., Aldini, G., and Colombo, L., Characterization of the intermediate products of lipid peroxidation in phosphatidylcholine liposomes by fast-atom bombardment mass spectrometry and tandem mass spectrometry techniques, Rapid Commun. Mass Spec., 10, 1148, 1996. 

This section deals with some general principles of tandem mass spectrometry and its applicability to quantitative analysis. The MS/MS acronym is used in this book as a general term for aU tandem mass spectrometry techniques. More detailed descriptions of how the principles are exploited in practice for the various instrumental types are given in later sections of this chapter. The general concept of tandem mass spectrometry in qualitative (structural) analysis is that additional chemical information, over and above that contained in a conventional onedimensional mass spectrum, can be obtained by examining the connectivity relationships among some or all of the ions in that mass spectrum. The connectivities arise as a result of the dissociation reactions that lead to the fragment ions in a mass spectrum, e.g. ... 

Different kinds of tandem mass spectrometry techniques have been applied to different types of purified triterpenoid saponins from natural medicinal plants [23, 28, 29, 33, 39, 43 7]. ESI [23, 28, 29, 33, 39, 43, 44, 46, 47] and Matrix-assisted... 

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