Isotope dilution gas chromatography-mass

McCann MT, Thompson MM, Gueron IC et al. (1996) Methyl malonic acid quantification by stable isotope dilution gas chromatography-mass spectrometry from filter paper urine samples. Clin Chem 42 9io-9i4. 

The development of new fiber coatings in the near future should further improve the specificity of SPME and overcome some of the observed matrix effects. Quantification by stable isotope dilution gas chromatography/mass spectrometry (GC/MS) may assist in improving analytical performance. Along with the possible application of micro LC and capillary LC columns to in-tube SPME, the development of novel derivatization methods and the potential for the analysis of fumigant pesticides, SPME appears to be a technique with a future in the analysis of pesticide residues in food. 

Isotope dilution gas chromatography-mass spectrometry has also been used for the determination of ppb of total chromium in seawater [181-183]. The samples were reduced to ensure Cr111 and then extracted and concentrated as tris (l,l,l-trifluoro-2,4-pentanediono) chromium (III) [(Cr(tfa)3>] into hexane. The Cr(tfa)2 mass fragments were monitored into a selected ion monitoring (SIM) mode. 

Lopez-Avila et al. [36] used a stable isotope dilution gas chromatography-mass spectrometric technique to determine down to O.lppb of pentachlorophenol (also Atrazine, Diazinon and lindane) in soil. Soil samples are extracted with acetone and hexane. Analysis is performed by high-resolution gas chromatography-mass spectrometry with mass spectrometer operated in the selected ion monitoring mode. Accuracy greater than 86% and a precision better than 8% were demonstrated by use of spiked samples. 

The isotope dilution gas chromatography-mass spectrometry method described by Lopez-Avila et al. [16] and fully discussed in section 5.3.1.3, has been applied to the determination of 0.1 1pg kg-1 Lindane in soil. Accuracy was greater than 86% and precision better than 8%. 

The isotope dilution gas chromatography-mass spectrometry method described by Lopez-Avila et al. [16] and discussed in section 5.3.1.3 has been applied to the determination of Atrazine in soil. In this method known amounts of labelled Atrazine were specked into soil samples before extraction with acetone-hexane. The ratio of the naturally abundant compound and the stable-labelled isotope was determined by high-resolution gas chromatography-mass spectrometry with the mass spectrometer in the selected ion monitoring mode. Detection limits of 0.1-l.Oppb were achieved. Accuracy was >86% and precision better than 8%. 

Blomquist, B. W., A. R. Bandy, D. C. Thornton, and S. Chen, Grab Sampling for the Determination of Sulfur Dioxide and Dimethyl Sulfide in Air by Isotope Dilution Gas Chromatography/Mass Spectrometry, J. Atmos. Chem., 16, 23-30 (1993). 

Lopez-Avila V, Hirata P, Kraska S, et al. 1985. Determination of atrazine, lindane, pentachlorophenol, and diazinon in water and soil by isotope dilution gas chromatography/mass spectrometry. Anal Chem 57 2797-2801. 

Stable Isotope Dilution Gas Chromatography/Mass Spectrometry... 

Stable-Isotope Dilution Gas Chromatography-Mass Spectrometry Method for the Determination of GA and Cr in Body Fluids... 

Byrd, G.D., Fowler, K.W, Hicks, R.D., Lovette, M.E. Borgerding, M.F. (1990) Isotope dilution gas chromatography-mass spectrometry in the determination of benzene, toluene, styrene and acrylonitrile in mainstream cigarette smoke. J. Chromatog., 503, 359-368... 

Colby, B. N. Beimer, R. G. Rushneck, D. R. Telliard, W. A. Isotope Dilution Gas Chromatography-Mass Spectrometry for the Determination of Priority Pollutants in Industrial Effluents Effluent Guidelines Division. U.S. Environmental Protection Agency. U.S. Government Printing Office Washington, DC, 1980. 

Adlercreutz H, Fotsis T, Lampe J, Wahala T, Makela T, Brunow G, Hase T. 1993. Quantitative determination of lignans and isoflavonoids in plasma of omnivorous and vegetarian women by isotope dilution gas chromatography-mass spectrometry. Scand J Clin Lab Invest 53 5-18. 

Dichlorophenoxy acetic acid Isotope dilution gas chromatography-mass spectrometry. [404]... 

Cassada, D.A., R.F. Spalding, Z. Cai, and M.L. Gross (1994). Determination of atrazine, deethylatrazine and deisopropylatrazine in water and sediment by isotope dilution gas chromatography-mass spectrometry. Anal. Chim. Acta, 287(1-2) 7-15. 

Knust U, Strowitzki T, Spiegelhalder B, Bartsch H, Owen RW (2007) Optimization of an isotope dilution gas chromatography/mass spectrometry method for the detection of endogenous estrogen metabolites in urine samples. Rapid Commun Mass Spectrom 21 2245-2254... 

Colby, B. N., Colby, M. E., and Rosecrance, A. E. (1981). Measurement parameter selection for quantitative isotope dilution gas chromatography/mass spectrometry. Anal. Chem. 53, 1907-1911. 

Johnson, L. P., McLeod, J. K., Summons, R. E., and Hunt, N. (1980). Design of a stable isotope dilution gas chromatography/mass spectrometric assay for cAMP Comparison with standard protein-binding and radioimmunoassay methods, Anal. Biochem. 106,285-290. 

Jonckheere, J. A., De Leenheer, A. P., and Steyaert, H. L. (1982). Statistical evaluation of calibration curve non-linearity in isotope dilution gas chromatography/mass spectrometry. Anal. Chem. 55, 153-155. 

M. A. Sochaski, A. J. Jenkins, T. J. Lyons, S. R. Thorpe, J. W. Baynes, Isotope dilution gas chromatography/mass spectrometry method for the determination of methionine sulfoxide in protein, Anal. Chem., 73 (2001), 4662-4667. 

F. Yang, R. E. Sturgeon, S. McSheehy, Z. Mester, Comparison of extraction methods for quantitation of methionine and selenomethionine in yeast by species specific isotope dilution gas chromatography-mass spectrometry, J. Chromatogr. A, 1055 (2004), 177-184. 

Determination of oxidized amino acids in urine is usually performed by isotope dilution gas chromatography-mass spectrometry (L9). DOPA is estimated by HPLC separation of acid protein hydrolysates with fluorescence detection (excitation 280 nm, emission at 320 nm) (A15). Other methods are based on borate-hydrochloric acid difference spectroscopy (this method suffers interference from tyrosine and tryptophan) (W2), derivatization of DOPA with nitrite and subsequent coulometric determination (W3), and fluorometric detection after derivatization with ethylenediamine (A15). 3-Hydroxylysine is quantitated by HPLC with 9-fluorenylmethyl chloroformate precolumn derivatization (M25) of amino acids obtained by gas-phase hydrolysis of proteins (F21). Other general methods to detect amino acid damage are mass spectometry methods applied to protein hydrolysates, such as tandem mass spectrometry (F6). 

Moler GF, Delongchamp RR, Korfmacher WA, Pearce BA, Mitchum RK (1983), Anal. Chem. 55 835-841. Confidence limits in isotope dilution gas chromatography/mass spectrometry11... 

Raff, I., Denk, R., Sachs, H., Monoacetylmorphin in Haaren, Zbl. Rechtsmed., 36, 479,1991. Nakahara, Y., Takahashi, K., Shimamine, M., Takeda, Y, Hair Analysis for Drugs of Abuse. I. Determination of Methamphetamine and Amphetamine in Hair by Stable Isotope Dilution Gas Chromatography/Mass Spectrometry Method, /. Forensic Sci., 36, 70,1991. 

Nakahara, Y., Takahashi, K., Takeda, Y., Kunoma, K., Fukui, S., and Tokui, T., Hair analysis for drug abuse. Part II. Hair analysis for monitoring of methamphetamine abuse by stable isotope dilution gas chromatography/mass spectrometry. Forensic Sci. Int., 46, 243, 1990. 

AUen, M.S., Lacey, M.J., and Boyd, S. (1994). Determination of methoxypyrazines in red wines by stable isotope dilution gas chromatography-mass spectrometry. J. Agric. Food Chem., 42, 1734-1738. 

Prouteau, C., Schneider, R., Lucchese, Y., Nepveu, F, Renard, R., and Vaca-Garda, C. (2004). Improving headspace-solid-phase microextraction of 3-isobutyl-2-methoxypyrazine by experimental design with regard to stable isotope dilution gas chromatography-mass spectrometric analysis of wine. Anal. Chim. Acta, 513, 223-227. 

Byrd, G.D., Paule, R.C., Sander, L.C. (1992). Determination of 3-quinuclidinyl benzilate (QNB) and its major metabolites in urine by isotope dilution gas chromatography/mass spectrometry. J. Anal. Toxicol. 16 182-7. 

Barr, J.R., Driskell, W.J., Aston, L.S., Martinez, R.A. (2004). Quantitation of metabolites of the nerve agents sarin, soman, cyclohexylsarin, VX and Russian VX in human urine using isotope-dilution gas chromatography-mass spectrometry. J. Anal. Toxicol. 28 372-8. 

Norwood, D.L. Prime, D. Downey, B.P. Creasey, J. Satinder, S.K. Haywood, P. Analysis of polycyclic aromatic hydrocarbons in metered dose inhaler drug formulations by isotope dilution gas chromatography/ mass spectrometry. J. Pharm. Biomed. Anal. 1995, 13 (3), 293-304. 

Thienpont, L.M. Van Nieuwenhove, B. Reinuer, H. De Leenheer, A.P. Determination of reference method values by isotope dilution-gas chromatography-mass spectrometry A five years experience of two European reference laboratories. Eur. J. Clin. Chem. Clin. Biochem. 1996, 34, 853-860. 

Kock, R. Delvoux, B. Tilhnanns, U. Greihng, H. A candidate reference method for the determination of uric acid in serum based on high-performance hquid chromatography, compared with an isotope dilution-gas chromatography-mass spectrometer method. J. Chn. Chem. Clin. Biochem. 1989, 27, 157-162. 

De Brabandere VI, Thienpont LM, Stockl D, De Leenheer AP. Three routine methods for serum cortisol evaluated by comparison with an isotope dilution gas chromatography-mass spectrometry method. Clin Chem 1995 41 1781-3. 

Thienpont L, Siekraann L, Lawson A, Colinet E, De Leenheer A. Development, vaUdation, and certification by isotope dilution gas chromatography-mass spectrometry of lypholized human serum reference materials for cortisol (CRM 192 and 193) and progesterone (CRM 347 and 348). Clin Chem 1991 37 540-6. 

Taieb J, Mathian B, Millot F, Patricot M-C, Mathieu E, Queyrel N, et al. Testosterone measured by 10 immunoassays and by isotope-dilution gas chromatography-mass spectrometry in sera from 116 men, women, and children, Clin Chem 2003 49 1381-95. 

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