Spectometry mass

Unger, S.E. Cooks, R.G. (1979). Application of mass spectometry, mass spectometry (MS/MS) to the identification of natural products in Psilocybe cyanescens. Analytical Letters 12 (Part B), 1157-1167. 

While the molecular masses of expanded [n]pericyclines 82,83,122 can easily be determined by GC-MS analysis, higher dehydrocyclooligomers fail to vaporize sufficiently [7]. Fast atom bombardment mass spectometry (FAB-MS) had to be applied for the characterization of the acetal-protected expanded pericyclinones 123-126 and 176 [39]. Attempts to determine the molecular masses of the... 

FID = flame ionization detector GC = gas chromatography HSD halogen-selective detector MS = mass spectometry NR = not reported... 

Fay, L.B., Metairon, S., and Blank, I. 2000. Stable isotope dilution assay mass spectometry in flavour research Internal standard and calibration issues. In Frontiers of Flavour Science (P. Schieberle and K.-H. Engel, Eds.) Deutsche For-schungsanstalt ftlr Lebensmittelchemie, Garching, Germany. 

IMPA IT-SIMS isopropyl methylphosphonic acid ion-trap secondary ion mass spectometry... 

Castillo M, Oubina A, Barcelo D. 1998. Evaluation of ELISA kits followed by liquid chromatography-atmospheric pressure chemical ionization-mass spectometry for the determination of organic pollutants in industrial effluents. Environ Sci Technol 32 2180-2184. 

Table 1 Typical Inductively Coupled Plasma Mass Spectometry Operating Conditions...

Determination of oxidized amino acids in urine is usually performed by isotope dilution gas chromatography-mass spectrometry (L9). DOPA is estimated by HPLC separation of acid protein hydrolysates with fluorescence detection (excitation 280 nm, emission at 320 nm) (A15). Other methods are based on borate-hydrochloric acid difference spectroscopy (this method suffers interference from tyrosine and tryptophan) (W2), derivatization of DOPA with nitrite and subsequent coulometric determination (W3), and fluorometric detection after derivatization with ethylenediamine (A15). 3-Hydroxylysine is quantitated by HPLC with 9-fluorenylmethyl chloroformate precolumn derivatization (M25) of amino acids obtained by gas-phase hydrolysis of proteins (F21). Other general methods to detect amino acid damage are mass spectometry methods applied to protein hydrolysates, such as tandem mass spectrometry (F6). 

A (D-glucosylamine)uronic acid derivative has been identified331 as the metabolite of carbamazepine (5//-dibenz[fe,/]azepine-5-carbox-amide, an anti-epileptic agent) by means of permethylation, g.l.c., and mass spectometry. Analytical data for the conjugate (identified in the bile of the isolated, perfused, rat liver) indicated that the carboxamide nitrogen atom is linked to C-l of the sugar moiety. 

Christiansen, A.L., Rasmussen, K.E. (1982). Analysis of indole alkaloids in Norwegian Psilocybe semilanceata using high-performance liquid chromatography and mass spectometry. Journal of Chromatography, 244, 357-364. 

Pruszkowski E, Neubauer K, Thomas R. An overview of clinical applications by inductively coupled plasma mass spectometry. Atomic Spectroscopy 1998 19 115. 

F Bitsch, S Herter, K Mueller, F Gombert. Nonoelectrospray ionization mass spectometry as a tool for mass measuring compounds synthesized on beads. Proceedings of the 45th ASMS Conference on Mass Spectrometry and Allied Topics, Palm Springs, CA, 1997, p. 1263. 

RG Smith, S Woodard, K Leschinsky. Mixture analysis using LC/APCI/MS. Proceedings of the 44th ASMS Conference on Mass Spectometry and Allied Topics, Portland, OR, 1996, p. 1036. 

MC Fitzgerald, K Harris, CG Shevlin, G Siuzdak. Direct characterization of solid phase resin-bound molecules by mass spectometry. Bioorg Med Chem lett 6(8) 979-982, 1996. 

J Boutin, P Henning, P Lambert, S Berlin, L Petit, J-P Mahieu, B Serkiz, J-P Volland, JL Fauchere. Combinatorial peptide libraries robotic synthesis and analysis by NMR, mass spectometry, tandem mass spectrometry and high-performance capillary electophoresis techniques. Anal Biochem 234 126-141,... 

Y-H Chu, YM Dunayevskiy, DP Kirby, P Vouros, BL Karger. Affinity capillary electrophoresis-mass spectometry for screening combinatorial libraries. J Am Chem Soc 118 7827-7835, 1996. 

Gates, R Reather, J. Staunton, J. Accurate-Mass MSn Studies of Natural Products (Polyketides) by ESI-FT-ICR Mass Spectometry, in Proceedings of the 47th ASMS Conference on Mass Spectrometry and Allied Topics, Dallas, Texas, June 13-17, 1999. 

Mass Spectometry Facility, University of Calitbrnia, San Francisco, California 94143... 

A point that may seem fairly obvious, but worth reiterating, is that, with a complex mixture from which one or a few specific compounds are to be isolated, a means of keeping track of the compound through the extraction process is needed. There are two main ways to follow a compound (1) physical assay (for example, HPLC, thin-layer chromatography [TLC], liquid chromatography-mass spectometry [LC-MS], and perhaps involving comparison with a standard), or (2) bioactivity assay. 

Another tracer technique was introduced for carbon dating of archeological specimens. Accelerator mass spectometry (AMS) is based on measuring atomic weight ratios of atoms in extremely small samples. 

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