Inspiration inspired

In the INSIDE project (INSIDE, 1997) has been developed a toolkit called InSPIRE. InSPIRE is a hyperbook development which provides chemists and... 

Perception and Entropy Inspired Ultrasonic Grain Noise Suppression, Using Noncoherent Detector Statistics. 

We would like to acknowledge A P Alivisatos and C V Shank, as well as all past and current members of the Alivisatos group for their insight and help with many of the ideas and data presented in this chapter. We would also like to acknowledge Steve Robertson for inspired assistance with the references and figures. 

The authors are indebted to Professor Michael Baer for many years of exciting collaboration, to Dr. B. Halperin for advice, to F rofessor Mark Pere lmanfor discussion and permission to quote from his preprint Temporal Magnitudes and Functions of Scattering Theory, to Professor Shmuel Elitzur for suggesting the approach leading to Alternative Derivation in Section V and to Professor Tgal Talmi for an inspiration [327],... 

Experimental techniques based on the application of mechanical forces to single molecules in small assemblies have been applied to study the binding properties of biomolecules and their response to external mechanical manipulations. Among such techniques are atomic force microscopy (AFM), optical tweezers, biomembrane force probe, and surface force apparatus experiments (Binning et al., 1986 Block and Svoboda, 1994 Evans et ah, 1995 Israelachvili, 1992). These techniques have inspired us and others (see also the chapters by Eichinger et al. and by Hermans et al. in this volume) to adopt a similar approach for the study of biomolecules by means of computer simulations. 

Contrary to the impression that one might have from a traditional course in introductory calculus, well-behaved functions that cannot be integrated in closed form are not rare mathematical curiosities. Examples are the Gaussian or standard error function and the related function that gives the distribution of molecular or atomic speeds in spherical polar coordinates. The famous blackbody radiation cuiwe, which inspired Planck s quantum hypothesis, is not integrable in closed form over an arbitiar y inteiwal. 

Despite this overwhelming body of evidence, two-step mechanisms have been suggested for the Diels-Alder reaction, probably inspired by special cases, where highly substituted dienes and/or dienophiles have been found to react through zwitterionic or biradicalintermediates (Scheme 1.2). 

Alternatively, authors have repeatedly invoked the internal pressure of water as an explanation of the rate enhancements of Diels-Alder reactions in this solvent ". They were probably inspired by the well known large effects of the external pressure " on rates of cycloadditions. However, the internal pressure of water is very low and offers no valid explanation for its effect on the Diels-Alder reaction. The internal pressure is defined as the energy required to bring about an infinitesimal change in the volume of the solvents at constant temperature pi = (r)E / Due to the open and... 

Niek Buurma and Theo Rispens are most gratefully acknowledged for the inspiring discussions on hydrophobic effects. These discussions have contributed significantly to a better understanding of this topic and form the basis of what is described in Section 1.3. 

Perhaps the most extensively studied catalytic reaction in acpreous solutions is the metal-ion catalysed hydrolysis of carboxylate esters, phosphate esters , phosphate diesters, amides and nittiles". Inspired by hydrolytic metalloenzymes, a multitude of different metal-ion complexes have been prepared and analysed with respect to their hydrolytic activity. Unfortunately, the exact mechanism by which these complexes operate is not completely clarified. The most important role of the catalyst is coordination of a hydroxide ion that is acting as a nucleophile. The extent of activation of tire substrate througji coordination to the Lewis-acidic metal centre is still unclear and probably varies from one substrate to another. For monodentate substrates this interaction is not very efficient. Only a few quantitative studies have been published. Chan et al. reported an equilibrium constant for coordination of the amide carbonyl group of... 

Inspired by the work of Burk and Feaster ) we attempted to use (2-pyridyl)hydrazine (4.36) as a coordinating auxiliary (Scheme 4.10). Hydrazines generally react effidently with ketones and aldehydes. Hence, if satisfactory activation of the dienophile can be achieved through coordination of a Lewis acid to the (2-pyridyl)hydrazone moiety in water. Lewis-add catalysis of a large class of ketone- and aldehyde-activated dienophiles is antidpated Subsequent conversion of the hydrazone group into an amine functionality has been reported previously by Burk and Feaster ... 

Inspired by the many hydrolytically-active metallo enzymes encountered in nature, extensive studies have been performed on so-called metallo micelles. These investigations usually focus on mixed micelles of a common surfactant together with a special chelating surfactant that exhibits a high affinity for transition-metal ions. These aggregates can have remarkable catalytic effects on the hydrolysis of activated carboxylic acid esters, phosphate esters and amides. In these reactions the exact role of the metal ion is not clear and may vary from one system to another. However, there are strong indications that the major function of the metal ion is the coordination of hydroxide anion in the Stem region of the micelle where it is in the proximity of the micelle-bound substrate. The first report of catalysis of a hydrolysis reaction by me tall omi cell es stems from 1978. In the years that... 

Chemistry does not always enjoy the best of reputations. Many of our plants and refineries are still potentially dangerous and may pollute their surroundings. At the same time our society enjoys a high standard of living not in small measure through the results of chemistry, which few would give up. I believe that chemistry can and will be able to bring about an equilibrium between mankind s needs and our environmental concerns. Chemistry will continue to benefit mankind in the spirit of Alfred Nobel, a fellow chemist whose example continues to inspire us all. 

More recently PCR proved to be a valuable detection and analytical tool during the terrorist inspired anthrax outbreak m the fall of 2001... 

The onset of action is fast (within 60 seconds) for the intravenous anesthetic agents and somewhat slower for inhalation and local anesthetics. The induction time for inhalation agents is a function of the equiUbrium estabUshed between the alveolar concentration relative to the inspired concentration of the gas. Onset of anesthesia can be enhanced by increasing the inspired concentration to approximately twice the desired alveolar concentration, then reducing the concentration once induction is achieved (3). The onset of local anesthetic action is influenced by the site, route, dosage (volume and concentration), and pH at the injection site. 

Ion-selective electrodes and amperometric ceUs have had a long history of success in a wide variety of appHcations (8,9). A microelectronics-inspired revolution is also occurring in these devices, brought about by the advent of photoHthographicaHy defined arrays of microelectrodes on planar substrates... 

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