Researchers inspired

He was born in Macon, Ga., on May 4, 1906, and received his B.S. in chemistry in 1928 and his Ph.D. in physiological chemistry in 1931 at Yale. While at Yale he received research inspiration, which never left him throughout life, from Professor L. B. Mendel, to whose memory Block remained fiercely loyal. Block was a friend to his friends. While he acknowledged his enemies, he ignored them, not permitting them to affect his way of life or his convictions. To him enemies were like booby traps or dangerous leaks in the roof They merely required attention of a strictly technical nature. 

This section aims at discussing how good biosensor research inspires the scien-hfic community to achieve advancements that reach from novel basic concepts to... 

Some interaction and inverse scattering research inspired by the Kuo-Brown matrix elements ... 

Research Projects Agency (DARPA) for the purpose of remotely operating on injured soldiers. This research inspired the development of two commercial telesurgery systems. 

A literature analysis marks the starting point of the research process. Relevant research fields are, for instance, supply chain performance measurement or customer service literature rooted in marketing. The theory-based analysis helps to keep track of initial theoretical or practical indications and crystallize them Avithin a first conceptual model explaining the relation between the value drivers of SCM and the EVA as relevant business metric. This part expresses deductive research. The conceptual model is subsequently tested in practice to disclose inconsistencies and customize the degree of specification. Remarks and suggestions made by practice, reflecting the inductive research, inspire fiuther descriptions and improvement. The knowledge acquisition... 

They constitute a new area of research, inspired by biology and, as the name suggests, the human immune system [13]. The purpose of the immune system is to protect the body against pathogens. The term pathogens should be understood as viruses, bacteria, parasites and other micro-organisms which threaten the living... 

With the discovery of the crowns and related species, it was inevitable that a search would begin for simpler and simpler relatives which might be useful in similar applications. Perhaps these compounds would be easier and more economical to prepare and ultimately, of course, better in one respect or another than the molecules which inspired the research. In particular, the collateral developments of crown ether chemistry and phase transfer catalysis fostered an interest in utilizing the readily available polyethylene glycol mono- or dimethyl ethers as catalysts for such reactions. Although there is considerable literature in this area, much of it relates to the use of simple polyethylene glycols in phase transfer processes. Since our main concern in this monograph is with novel structures, we will discuss these simple examples further only briefly, below. 

Medicinal chemistry has frequently drawn inspiration and important new leads from the examination of natural products, and this was proven to be the case once more. In 1992, researchers at Merck and Glaxo announced, almost simultaneously, the independent discovery of the same new class of natural products from two different fungi. As a consequence, the same family of natural products has two names - the zaragozic acids (Merck)4 or the squalestatins (Glaxo).5 A typical member of the family, zaragozic acid A (squa-lestatin SI) (1) was shown to have a tremendous affinity for squalene synthase (K, = 79 pM for rat microsomal squalene synthase) and could even lower serum cholesterol levels in vivo in a population of marmosets.6... 

I wish to express my sincere thanks to Prof. A. Sommerfeld, from whose Seminar much of the inspiration for this research was obtained. I am also indebted to the John Simon Guggenheim Memorial Foundation and to the California Institute of Technology for providing the opportunity for its prosecution. 

Stacey started research in an inspiring and stimulating atmosphere that he strove to maintain, add to, and develop when it became his turn to lead the department. His earliest research was with Haworth and his key partner E. L. Hirst [Adv. Carbohydr. Chem. Biochem., 35 (1978) 1 -29] on aspects of the chemistry of glucoheptose. His first publication with them in 1931 was entitled Walden Inversion in the a-Glucoheptose Series, followed in the next year by a report on the methylation of monocarboxylic acids derived from aldoses and the structure of pentamethyl a-gluco-heptonolactone. He found this to be a difficult project because, initially, he could not crystallize his stock of glucoheptose. Then, as later, he found crystallization to be a challenging problem. 

This chapter has taken the reader through a number of microwave-assisted methodologies to prepare and further functionalize 2-pyridone containing heterocycles. A survey of inter-, intramolecular-, and pericyclic reactions together with electrophilic, nucleophilic and transition metal mediated methodologies has been exemplified. Still, a number of methods remain to be advanced into microwave-assisted organic synthesis and we hope that the smorgasbord of reactions presented in this chapter will inspire to more successful research in this area. 

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