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Alkaloid Natural Product-inspired Small-molecule Probes for XIAP

Alkaloid Natural Product-inspired Small-molecule Probes for XIAP [Pg.535]

With the goals of finding small-molecule promoters of apoptosis signaling by (i) enhancing the release of caspase-3 and (ii) disrupting XIAP/caspase-9 interactions, a collaborative study with Korneluk and MacKenzie Laboratories at the Apoptosis Research Centre, Children s Hospital of Eastern Ontario (CHEO) in Ottawa yielded natural product-inspired compounds that were tested in the following three assays [37]. [Pg.535]

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XIAP