Peptide/protein-inspired polymers

This chapter introduced the nature-inspired polymers with the ability to mimic cell activity for advanced drug and gene delivery. These polymers have been combined with biomolecules such as carbohydrates, peptides, and proteins, which played the prominent roles not only of excellent drug carriers but also of drug molecules themselves. For further... 

Paul van der Schoot, Nucleation and Co-Operativity in Supramolecular Polymers Michael J. McPherson, Kier James, Stuart Kyle, Stephen Parsons, and Jessica Riley, Recombinant Production of Self-Assembling Peptides Boxun Leng, Lei Huang, and Zhengzhong Shao, Inspiration from Natural Silks and Their Proteins Sally L. Gras, Surface- and Solution-Based Assembly of Amyloid Fibrils for Biomedical and Nanotechnology Applications... 

Lowik, D. IV. P. M., Ayres, L., Smeenk, J. M., VanHestJ. C. M. Synthesis of Bio-Inspired Hybrid Polymers Using Peptide Synthesis and Protein Engineering. Vol. 202, pp. 19-52. 

Synthesis of Bio-Inspired Hybrid Polymers Using Peptide Synthesis and Protein Engineering... 

Responsive peptides that are derived from naturally inspired motifs fall into two categories. First, responsive polypeptides can be prepared based on the structure of elas-tin, an extracellular matrix protein that is found in connective tissue such as skin and arteries (MacEwan Chilkoti, 2010). These materials typically respond to a stimulus through a change in conformation of the polymer. The second category of naturally inspired peptides consists of short peptide sequences that represent substrates for enzymes. In these materials, the change induced by the stimulus (the enzyme) is an alteration of the chemical functionality displayed on the material surface. Both response mechanisms are shown in Figure 3.4. 

Lowik DWPM, Ayres L, Smeek JM, Van Hest JCM (2006) Synthesis of bio-inspired hybrid polymers using peptide synthesis and protein engineering. Adv Pol3on Sci 202 19-52... 

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