Resistance inspiration

The success of quinine inspired the search for other antimalarials. The greatest impetus for the development of synthetic dmgs came this century when the two World Wars intermpted the supply of cinchona bark to the combatants. A stmcturally related 4-quinolinemethanol is mefloquine (65, Lariam [51773-92-3]) which now serves as an effective alternative agent for chloroquine-resistant P. falciparum. This is a potent substance that requires less than one-tenth the dose of quinine to effect cures. There are some untoward side effects associated with this dmg such as gastrointestinal upset and dizziness, but they tend to be transient. Mefloquine is not recommended for use by those using beta-blockers, those whose job requires fine coordination and spatial discrimination, or those with a history of epilepsy or psychiatric disorders. A combination of mefloquine with Fansidar (a mixture of pyrimethamine and sulfadoxine) is known as Fansimef but its use is not recommended. Resistance to mefloquine has been reported even though the compound has not been in wide use. 

Chromium, Cr, is a bright, lustrous, corrosion-resistant metal. Its name, which comes from the Greek word for color, was inspired by its colorful compounds. The metal is obtained from the mineral chromite, FeCr204, by reduction with carbon in an electric arc furnace ... 

In normal circumstances, the work done on expiration utilizes energy stored within the elastic tissues on inspiration. Expiration is, therefore, said to be passive unless the energy required to overcome airway resistance exceeds that which is stored. 

Inspiration The line ABC is the physiological line traced on inspiration. The area ACDA represents work to overcome elastic tissues resistance. The extra area enclosed by ABCA represents the work done in overcoming viscous resistance and friction on inspiration. If this resistance increases, the curve bows to the right as shown. 

Several authors measured attainable pressure drops as a function of the external resistance for different groups of volunteers. Healthy male subjects (during maximal inspiration) are able to create a pressure drop (on average) of 6.7 kPa through an airflow resistance of 0.038 kPa° min 1, (which is in the range of that of marketed DPIs, see Table 3.7), whereas females are able to create a pressure drop of 3.8 kPa under the same resistance [22]. Differences between different groups of patients depend on the degree to which pulmonary func-... 

If smart fibers began to be widely used, perhaps clothes and other fabrics would become more adaptable. Nature is one place to look for inspiration. Olivier Emile and Albert Le Floch of the Universite de Rennes in France and Fritz Vollrath at Oxford University in England studied why spiders rarely spin around when hanging from their silk threads. Most fibers turn and twist, as a climber dangling from a rope knows all too well, yet a suspended spider is stable. The researchers discovered that spider silk has a kind of shape memory in which it rapidly recovers its shape, resisting any twisting motion. This research, Shape Memory in Spider Draglines, was published in Nature in 2006. 

The association of sulfur and iron into simple to more complex molecular assemblies allows a great flexibility of electron transfer relays and catalysis in metalloproteins. Indeed, the array of different structures, the interactions with amino-acid residues and solvent and their effect on redox potential and spectroscopic signatures is both inspiring for chemists and electrochemists, and of paramount importance for the study of these centers in native conditions. Most of the simpler natural clusters have been synthesized and studied in the laboratory. Particularly, the multiple redox and spin states can be studied on pure synthetic samples with electrochemical and spectroscopic techniques such as EPR or Fe Mossbauer spectroscopy. More complex assembhes still resist structural... 

The knowledge that successful freeze-drying depends largely on the structure of the frozen product has inspired the development of methods to analyze and understand these structures more quantitatively. Rey [1.24] has shown that in addition to the electrical resistance (ER) of a freezing substance, the thermodynamic behavior can also be used to study the freezing process and the frozen product. 

The attractive properties of silk fibers as a natural, sustainable product have inspired researchers to look for options to fabricate such fibers without the use of worms or spiders. Furthermore, these natural polymers, silk proteins (both fibroin and spidroin), allow for adjustable mechanical properties, thermal resistance (Drummy et al., 2005 Motta et al., 2002), as well as biomedical compatibility (Vepari and Kaplan, 2007). 

More than a few artists have discovered inspiration in the presentation of geometric patterns. In early Canadian research, DMT was used successfully in propelling people who resisted LSD s effects into a psychedelic state. 

---