Imaging agents

Technetium-99m oxidronate is a bone imaging agent used to demonstrate areas of altered osteogenesis. It is rapidly cleared from the blood and taken up in areas of bone that are undergoing osteogenesis. The kit is a vial containing a lyophilized powder where sodium oxidronate is the active... 

Technetium-99m teboroxime is a myocardial imaging agent and is excreted primarily by the hepatobiliary system. It is rapidly taken up by the myocardium and mosdy washes out within 30 minutes. Imaging protocols are performed immediately after injection. The product is a lyopbili ed mixture of boronic acid, dioxine, and other excipients, and the agent is formed with a beating step. 

Technetium-99m medronate ( Tc methylene diphosphonate) is used as a bone imaging agent to delineate areas of altered osteogenesis. The product is formed by the addition of up to 7.4 GBq (200 mCi) of Tc pertechnetate. 

Technetium-99m mertiatide (A/-[Ai-[A/-[(benzoylthio)acetyl]glycyl]glycine) is a renal imaging agent. It is excreted by the kidneys via active tubular secretion and glomerular filtration. The kit vial is reconstituted by using 740—3700 MBq (20—100 mCi) of Tc pertechnetate and boiling for 10 minutes. 

Technetium-99m bicisate is a brain imaging agent that is used for localization of stroke. The lyopbilized kit contains ethyl cysteine dimer as the active ingredient. 

Mousa SA, Bozarth JM, Edwards S et al (1998) Novel technetium 99m-labeled GPIIb/IIIa receptor antagonists as potential imaging agents for venous and arterial thrombosis. Coron Artery Dis 9 131-141... 

Whereas imaging agents that can serve to detect molecular and cellular processes must in some way directly or indirectly participate in these processes or interact with components participating in the processes, the development of X-ray contrast agents led in the opposite direction Molecules displaying the least possible interaction with body constituents and processes were preferred because of advantages in tolerability [2]. 

B. E. (1979). RadionucUde-labelled liposomes—A new lymph node imaging agent, Int. J. Nucl. Med. Biol.. 6, 75-83. 

Considerable interest has been focused on the efficient and rapid synthesis of 2-deoxy-2-[ F]fluoro-D-gIucose, a popular imaging agent for positron-emission tomography (see Section III, 1). However, introduction of a fluorine atom at C-2 by nucleophilic displacement is generally not easy on account of the weak nucleophilic character of the fluoride ion. One possible... 

Deoxy-2-[ F]fluoro-3-(9-methyl-D-glucopyranose was prepared by the reaction of methyl 4,6-0-benzylidene-3-0-methyl-2-0-triflyl-) -D-manno-pyranoside (159) with CsH F2, and the possibility of its use as an imaging agent was examined." ... 

In some cases, TcO can be used directly as an imaging agent. For example, the TcO anion... 

Application of [Ni(CN)4]2 as a tumor imaging agent has been reported.4 4... 

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