Tumour imaging agents

Also the preparation of the tumour imaging agents 5-[ F]fluorocytosine [108] (Scheme 28) and cytosine derivative [ F]capecitabine [109] can be considered as a direct /7eferoaromatic electrophilic dehydrogenation. 

Although contrast enhancement with the agents covered in this chapter mainly rehes upon a more distinct perfusion of tumours compared to normal tissue, as is achieved with ICG, and does not employ target-specific moieties, the value of contrast-enhanced tumour imaging was successfully demonstrated. These agents represent the classical format of a contrast agent. 

The ketahzation of [4- F]fluoroacetophenone required a careful adjustment of reaction conditions [175]. It has been carried out in order to prepare fluorine-18 labelled progestin ketals, potential imaging agents for breast tumours. 

Serum transferrin is normally only about 30% saturated with iron. This explains why it has a relatively high capacity for binding other metals and so is implicated in the transport of 67Ga,1139 which is used as an imaging agent for various soft tissue tumours and inflammatory abscesses.1140 Transferrin also facilitates movement of gallium across tumour cell membranes.1141... 

Temming K, Schiffelers RM, Molema G, Kok RJ. RGD-based strategies for selective delivery of therapeutics and imaging agents to the tumour vasculature. Drug Resist Updat 2005 8 381-402. 

Indium-Ill Accelerator Imaging agent for tumour localization... 

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