Imaging agents targeted delivery

Fig. 8 Nanosystems that may function as simultaneous drug delivery and imaging agents for targeting T cells (a) liposomal systems, (b) solid biodegradable nanoparticulates, and (c) macro-molecular dendrimer complexes. PEG polyethylene glycol, Gd-DTPA gadolininum-diethylene triamine penta acetic acid. (Adapted from [48])...

Fig. 34. Model of a functionalised (internally or externally) SWNT, which may be closed, open and/or corked reversibly or permanently after filling. Potentially the inner cavity may be filled with a (radio)-imaging agent (for PET/SPECT and/or MRI) or a (radio)therapeutic agent. Such functionalized SWNTs may conceivably act as probe prototype for multimodal imaging/therapy and targeted drug delivery (155).

See also Luminescent dendrimers antibacterial, 26 799 biocompatibility studies of, 26 800-801 in catalysis, 26 805-806 in cell targeting, 26 797-798 as chelators, 26 806-807 core and interior shells of, 26 789 cytotoxicity of, 26 800-801 in drug delivery, 26 792-795 in gene transfection, 26 791-792 as imaging agents, 26 795-797 luminescent, 26 801-804 medical applications of, 26 791-801 micelle-mimetic behavior of, 26 789 multiphoton applications of, 26 803-804... 

Fig. 8. Concentration dependence of ultrasound backscatter signal by plates coated with a layer of targeted microbubbles. Surface concentrations of microbubbles (as observed by bright-field optical microscopy, bottom) increase from left to right. Imaging performed using a fundamental frequency scheme. Samples placed on top of an ultrasound tissue phantom. Reprinted from Advanced Drug Delivery Reviews v. 37, A.L. Klibanov, Targeted delivery of gas-filled microspheres, contrast agents for ultrasound imaging, p. 145. Copyright, 1999, with permission from Elsevier Science...

A.L. Klibanov, Microbubble contrast agents Targeted ultrasound imaging and ultra-sound-assisted drug-delivery applications. Invest. Radiol. 41 (2005) 354-362. 

Torchilin, V.R., Immunoliposomes and PEGylated immunoliposomes possible use for targeted delivery of imaging agents. Immunomethods, 1994. 4(3) 244-58. 

Mehvar R (2000) Dextrans for targeted and sustained delivery of therapeutic and imaging agents. J Control Release 69 1-25... 

Lanza GM, Winter P, Caruthers S, et al. Novel paramagnetic contrast agents for molecular imaging and targeted drug delivery. Curr Pharm Biotechnol 2004 5 495-507. 

Muzykantov V. and Danilov, S. (1995) Targeting of radiolabeled monoclonal antibody against ACE to the pulmonary endothelium, in Targeted Delivery of Imaging Agents (Torchilin, V., ed.), CRC, Boca Ration, FL, pp. 465 485. 

As mentioned previously, the targeted delivery of suitable contrast agents for ultrasound or MRl imaging methodologies would be desirable for many applications. It remains to be seen whether microbubbles, magnetic nanoparticles or other active compounds can cross barriers in vivo (e.g., the endothehum) and can be delivered in sufficient amounts at sites of dis-... 

Furthermore, because the imaging agent works by depositing radiation energy proportionally to its concentration within the tumor, imaging the target provides dosimetry about dose delivery and is therefore important for planning the treatment. 

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