Agents for Magnetic Resonance Imaging

Sucralfate [54182-58-0] an aluminum salt of sucrose octasulfate, is used as an antacid and antiulcer medication (59). Bis- and tris-platinum complexes of sucrose show promise as antitumor agents (60). Sucrose monoesters are used in some pharmaceutical preparations (21). A sucrose polyester is under evaluation as a contrast agent for magnetic resonance imaging (mri) (61). Oral adrninistration of this substance opacifies the gastrointestinal tract and eliminates the need for purging prior to mri. 

Her present research interests are focused onto the design, synthesis of new lanthanide complexes as contrast agents for magnetic resonance imaging (MRI), as well as the development of a novel series of pH and p02 indicators for 111 NMR spectroscopic imaging ( II-MRSI). More recently, she has been involved in synthesis and evaluation of nanostructurated contrast agents. 

Idee JM, Port M, Raynal I, Schaefer M, Le Greneur S, Corot C (2006) Clinical and biological consequences of transmetallation induced by contrast agents for magnetic resonance imaging a review. Fundam. Clin. Pharmacol. 20 563-576. 

Super-paramagnetic (spm) crystals are used as contrast agents for Magnetic Resonance Imaging (MRI). Improving their efficiency requires a... 

A.M. Morawski, G.A. Lanza, S.A. Wickline, Targeted contrast agents for magnetic resonance imaging and ultrasound, Curr. Opin. Biotechnol. 16 (2005) 89-92. 

Young, S.W. et al. (1994) Preclinical evaluation of gadolinium(III) texaphyrin complex. A new paramagnetic contrast agent for magnetic resonance imaging, Invest Radiol. 29, 330-338. 

Armitage, F.E., Richardson, D.E., and Li, K.C., Polymeric contrast agents for magnetic resonance imaging synthesis and characterization of gadolinium diethylenetriaminepentaacetic acid conjugated to polysaccharides, Bioconjugate Chem., 1, 365-374, 1990. 

Rongved, P. and Klaveness, J., Water-soluble polysaccharides as carriers of paramagnetic contrast agents for magnetic resonance imaging synthesis and relaxation properties, Carbohydrate Res., 214, 315-323, 1991. 

Recently, it has been proposed that the Eu(II) cryptate with (2.2.2) is a good contrast agent for magnetic resonance imaging (see section on cyclen derivatives below). Firstly, the electronic configuration of the ion is identical to the one of Gd(III) secondly, two water molecules can interact with the Eu(II) ion, which is ten coordinate in water, instead of... 

The gadolinium complex with Cxi displays a reasonable relaxivity and it has been assessed as a potential contrast agent for magnetic resonance imaging. Its stability constant is however too low to make this complex a good candidate for in vivo applications. Until now, no calixarene derivative has proved efficient in this field, contrary to the pendant-arm substituted coronands. 

Aime, S., Botta, M., Fedeli, R, et al. (2001) High-relaxivity contrast agents for magnetic resonance imaging based on multisite interactions between a f -cyclodextrin oligomer and suitably functionalized Gdlll chelates. Chemistry - A European Journal, 7, 5261-5269. 

Lee, J., Zylka, M.J., Anderson, D.J., et al. (2005) A steroid-conjugated contrast agent for magnetic resonance imaging of cell signaling. Journal of the American Chemical Society, 127, 13164—13166. 

Caravan, R, Comuzzi, C., Crooks, W., et al. (2001) Thermodynamic stability and kinetic inertness of MS-325, a new blood pool agent for magnetic resonance imaging. Inorganic Chemistry, 40, 2170-2176. 

Parmelee, D.J., Walovitch, R.C., Ouellet, H.S., and Lauffer, R.B. (1997) PrecUnical evaluation of the pharmacokinetics, biodistribution, and eUmination of MS-325, a blood pool agent for magnetic resonance imaging. Investigative Radiology, 32, 741-747. 

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