Agents for Magnetic Resonance Imaging MRI

FIGURE 22.12 MRI scans of the brain of a patient with (a) Hallervorden—Spatz syndrome and (b) neuroferritinopathy. (From Crichton Ward, 2006. Copyright 2006 with permission from John Wiley and Sons.) 

FIGURE 22.13 (a) Structure of Gd-HPD03A. (b) Schematic representation of the dissociation of apoferritin into subunits at pH 2, followed 

FIGURE 22.14 Schematic representatioa of the adduct formed by C3d-Bio, streptavidin, and biotinylated Gd-loaded apoferritin (Gd-Apo-Bio). The sequence of the dendrimeric C3d-Bio NCAM mimetic peptide is outlined. (From Geninatti Crich et al, 2006. Copyright 2006 with permission from AACR.) 

Unfortunately, attempts to increase the relaxivity per particle failed, as the preparation method used does not allow the inclusion of more than 8 10 Gd-HPD03A molecules per apoferritin cavity. The task of internalizing a much greater number of paramagnetic centres inside the apoferritin cavity has been pursued by dissolving the solid P-MnOOH phase that one may create by exposing the protein to a concentrated solution of Mn(ll) salts at 

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Sucralfate [54182-58-0] an aluminum salt of sucrose octasulfate, is used as an antacid and antiulcer medication (59). Bis- and tris-platinum complexes of sucrose show promise as antitumor agents (60). Sucrose monoesters are used in some pharmaceutical preparations (21). A sucrose polyester is under evaluation as a contrast agent for magnetic resonance imaging (mri) (61). Oral adrninistration of this substance opacifies the gastrointestinal tract and eliminates the need for purging prior to mri. 

Her present research interests are focused onto the design, synthesis of new lanthanide complexes as contrast agents for magnetic resonance imaging (MRI), as well as the development of a novel series of pH and p02 indicators for 111 NMR spectroscopic imaging ( II-MRSI). More recently, she has been involved in synthesis and evaluation of nanostructurated contrast agents. 

Super-paramagnetic (spm) crystals are used as contrast agents for Magnetic Resonance Imaging (MRI). Improving their efficiency requires a... 

FIGURE 15 Molecular structures of ligands of rare-earth-based contrast agents for magnetic resonance imaging (MRI). 

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