Tumor imaging agent

Application of [Ni(CN)4]2 as a tumor imaging agent has been reported.4 4... 

Okarvi, S.M., and al-Jammaz, I. (2003) Synthesis, radiolabelling and biological characteristics of a bombesin peptide analog as a tumor imaging agent, Anticancer Res 23, 2745-2750. 

Pentavalent Tc-DMSA has been evaluated as a soft tumor-imaging agent (Yokoya-ma et al. 1985). 

Yokoyama A, Hata N, Horiuchi K, Matsuda H, Saji H, Ohta H et al (1985) The design of a pentava-lent " Tc-dimercaptosuccinate complex as a tumor imaging agent. J Nucl Med 12 273-279... 

Cyr JE, Pearson DA, Manchanda R et al (1999) Characterization and radiolabelling chemistry of Tc-99m depreotide a somatostatin receptor binding tumor imaging agent. J Nucl Med 40(Suppl) 321 Dams ETM, Nijhof MW, Boerman OC et al (2000) Scintigraphic evaluation of experimental chronic osteomyelitis. J Nucl Med 41 896-902... 

The tumor imaging agent was designed in Japan in the early eighties [168,169] and used for the detection of medullary thyroid carcinomas and head and neck tumors in patients [170,171]. Planar and SPECT imaging were applied to rapidly assess head... 

The cw-isomer of 4-[ F]proline, but not the trans-isomer, is incorporated into murine protein, and only the c/i-isomer is taken up into tumors. This isomer has been studied as a tumor imaging agent, with collagen-rich tumor stmctural proteins being targeted. Initial results with urologic tumors were not promising. Uptake of the L-isomer of cA-4-[ F]proline into brain tumors appeared to be limited to areas where the blood-brain barrier was disrupted. Later studies showed preferential uptake of the D-isomer of cw-4-[ F]proline into the brains of human subjects and apparently this isomerizes in the brain to the L-isomer." This is consistent with previous observations with the enantiomers of proline. 

Ohe et al. [67] reported the synthesis of ROMP block copolymers containing a tumor-imaging agent for in vivo testing in mice. Amphiphilic triblock copolymers bearing the indocyanine green moiety were prepared by a combination of ROMP of norbornadiene (NBD) derivatives, Cu-catalyzed [2-l-3]-dipolar click reaction. 

Choi SR, Yang B, Plossl K, Chumpradit S, Wey SP, Acton PD, Wheeler K, Mach RH, Kung HP. Development of a Tc-99m labeled sigma-2 receptor-specific ligand as a potential breast tumor imaging agent. Nucl Med Biol 2001 28 657-666. 

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