Agent imaging/image contrast

Kinetics of the biodistribution must be compatible with the practical aspects of hospital routine and imaging capabiUty. In the case of a diagnostic agent, maximal lesion contrast, maximal radioactivity concentrations in tissue of interest, and minimal background radioactivity during the time imaging... 

Kobayashi, H., Kawamoto, S., Star, R.A., Waldmann, T.A., Tagaya, Y., and Brechbiel, M.W. (2003) Micro-magnetic resonance lymphangiography in mice using a novel dendrimer-based magnetic resonance imaging contrast agent. Can. Res. 63, 271-276. 

Cyclam is one of the most extensively investigated ligands in coordination chemistry [23]. Both cyclam and its 1,4,8,11-tetramethyl derivative in aqueous solution can be mono and diprotonated and can coordinate metal ions such as Co2+, Ni2+, Cu2+, Zn2+, Cd2+, and Hg2+ with very large stability constants [24]. Furthermore, cyclam and its derivatives have been studied in medical applications [25], as carrier of metal ions in antitumor [26], imaging contrast agents [27], and as antiHIV agents [28]. 

Keywords Metallofullerene, endohedral, gadolinium, magnetic resonance imaging, contrast agent, relaxivity, cellular imaging, molecular imaging... 

S.D. Camthers, P.M. Winter, S.A. Wickline, G.M. Lanza, Targeted magnetic resonance imaging contrast agents. Methods Mol. Med. 124 (2006) 387-400. 

Lin YS, Hung Y, Su JK, Lee R, Chang C, Lin ML, Mou YC (2004) Gadolinium(III)-incorporated nanosized mesoporous silica as potential magnetic resonance imaging contrast agents. J Phys Chem B 108 15608-15611... 

Keywords Magnetic resonance imaging, Contrast agent, Smart, Targeting, Chelate... 

Copper has been immobilized on glycylglycine bolaamphiphile peptide nanotubes that display histidine residues, and paramagnetic gadolinium, a magnetic resonance image contrast agent, has been immobilized on nanofibers produced from peptide amphiphiles (see Gazit, 2007 and references therein). 

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