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Hydroxypropyl acetate succinate

Duloxetine hydrochloride, a novel anti-depressive, is known to be acid labile and, consequently, it has been formulated as an enteric-coated tablet. Interestingly, Jansen et al. [97] subsequently found that the drug was destabilised by degradation products within these enteric polymers. The authors found that succinyl and phthalyl residues from the hydroxypropyl methylcellulose acetate succinate (HPMCAS) and hydroxypropyl methylcellulose phthalate (HPMCP) formed... [Pg.39]

Abbreviations. BZC, benzalkonium chloride PS, potassium sorbate CDs, cyclodextrins HP-fS-CD, 2-hydroxypropyl-p-cyclodextrin HPMCAS, hydroxypropyl methylcellulose acetate succinate PEG, polyethylene glycol P-407, poloxamer 407 PVAP, poly vinylacetate phthalate. [Pg.28]

Cappon GD, Fleeman TL, Rocca MS, et al. Embryo/fetal development studies with hydroxypropyl methylcellulose acetate succinate (HPMCAS) in rats and rabbits. Birth Defects Res (Part B) 2003 68 421. [Pg.34]

Hydroxypropyl methylcellulose acetate succinate (HPMCAS) dissolves at pH higher than 5, and there are three kinds of HPMCAS—AS-LG, AS-MG, and AS-HG. Triethyl citrate is a common plasticizer used with HPMCAS. [Pg.185]

Jansen PJ, Oren PL, Kemp CA, Maple SR, Baertschi SW. Characterization of impurities formed by interaction of duloxetine HC1 with enteric polymers hydroxypropyl methylcellulose acetate succinate (HPMCAS) and hydroxypro-pyl methylcellulose phthalate (HPMCP). J Pharm Sci 1998 87(1) 81—85. [Pg.50]

Another example of an amine reacting with a formulation component is found in the case of duloxetine hydrochloride (84). This example, which is also discussed in Chapter 2, is summarized in Figures 49 and 50. In this example, the secondary amine of duloxetine hydrochloride reacted with the enteric coating polymer hydroxypropyl methylcellulose acetate succinate (HPMCAS) to form a succinamide degradation product. This reaction occurred under both stress conditions (60°C for 14 days) and during formal stability studies (30°C/60% relative humidity and 40°C/75% relative... [Pg.78]

For hydroxypropyl methylcellulose acetate succinate, a novel enteric dry coating method has been developed [31]. The unique feature of this method is that the enteric polymer is added in powder form (e.g., mixed with talcum directly to tablets or pellets) whereas a plasticizer diluted with paraffin is sprayed separately. The tablet core temperature is around 40°C, and the film is cured for a short time. To achieve a homogenous film, the rates of powder feeding and plasticizer spray have to be adjusted such that the two processes start and end simultaneously. [Pg.21]

Cellulose acetate Cellulose acetate butyrate Cellulose acetate phthalate Cellulose acetate propionate Ethyl cellulose Hydroxyethyl cellulose Hydroxypropyl cellulose Hydroxyethylmethyl cellulose Hydroxypropylmethyl cellulose Hydroxypropylmethyl cellulose acetate succinate Hydroxypropylmethyl cellulose phthalate Methyl cellulose Na Carboxymethyl cellulose... [Pg.490]

Hydroxypropyl methylcellulose acetate succinate Hydoxypropyl methylcellulose phthalate Methyl cellulose... [Pg.491]

Water-soluble hydroxypropylmethyl cellulose and water-insoluble cellulose acetate are further treated with phthalic anhydride or succinic anhydride to yield hydroxypropyl methylcellulose phthalate, cellulose acetate phthalate, and hydroxypropyl-methylcellulose acetate succinate. These polymers are used as enteric materials and are water soluble or insoluble above or below a specific pH, respectively. [Pg.491]

Aqoat Aqoat AS-HF/HG Aqoat AS-LP/LG-, Aqoat AS-MF/ MG cellulose, 2-hydroxypropyl methyl ether, acetate succinate HPMCAS. [Pg.350]

Hilton AK, Deasy PB. Use of hydroxypropyl methylcellulose acetate succinate in an enteric polymer matrix to design controlled-release tablets of amoxycillin trihydrate. J Pharm Sci 1993 82 737-743. [Pg.352]

Chen R, Sekulic S, Zelesky T. Development and validation of a cost-effective, efficient, and robust liquid chromatographic method for the simultaneous determination of the acetyl and succinoyl content in hydroxypropyl methylcellulose acetate succinate polymer. J AOAC Int 2002 85(4) 824-831. Correction 85(6), 125A. Onda Y, Muto H, Maruyama K. Ether-ester derivatives of cellulose and their applications. United States Patent No. 4,226,981 1980. Final report on the safety assessment of hydroxyethylcellulose, methylcellulose, hydroxypropyl methylcellulose and cellulose gum. J Am Coll Toxicol 1986 5 1-59. [Pg.353]

Hydroxypropyl Starch Hypromellose Acetate Succinate Inulin... [Pg.936]

In 1940, Eastman Kodak Company published a U.S. patent that provided one of the earliest de.scriptions of enteric coating of medicaments. The patent claimed the use of a cellulose derivative containing free carboxyl groups as an enteric film forming polymer. Specifically, the claimed enteric polymer was cellulose acetate phthalate (CAP) (34). Numerous enteric cellulose derivatives have been developed since this early account and these polymers remain as some of the most widely used for enteric coating applications. In addition to CAP these derivatives include cellulose acetate trimellitate (CAT), cellulose acetate succinate (CAS), hydroxypropyl methylcellulose phthalate (HPMCP), and hydroxypropyl methylcellulose acetate succinate (HPMCAS). The molecular structure of these polymers is depicted in Figure 1 with their respective substituent groups listed in the caption. [Pg.389]

FIGURE 4 Effects of the plasticizer level and curing conditions (indicated in the figure) on theophylline release from pellets coated with HPMCAS in O.IM HCI (20% coating level). Ahhreviation HPMCAS, hydroxypropyl ntethylcellu-lose acetate succinate. Source From Ref. 46. [Pg.392]

Methyl-, hydroxyethyl-, hydroxypropyl-, and carboxymethyl starches, starch acetates, succinates, alkenyl succinates (Fig. 2), adipates, and phosphates, are all well-known products. Furthermore, special derivatives have also been prepared, such as vinyl-, silyl-, ° or propargyl starches, as reactive intermediates for fiirther fime-tionalization. Unusual substitution patterns can also be established by highly selective deacetylation with alkyldiamines and subsequent introduction of such functional groups as sulfates. From die analytical point of view, the most important aspects are stability under alkaline (mediylation) and acidic or Lewis-acidic (depolymerization) conditions, reactivity (such as migration, rearrangement, further substitution or addition reactions, or any intramolecular reaction), and polarity (lipophilic/hydrophilic, ionic/nonionic, acidic/basic). These properties mainly determine the analytical... [Pg.126]

Hydroxypropyl methylcellulose phthalate Polyvinylpyrrolidone-co-vinyl acetate Hydroxypropyl methylcellulose Hydroxypropyl methylcellulose acetate succinate Poly(lactide-co-glycolide)... [Pg.219]

Vervaet et al. investigated another example of a core-sheU microcapsule system via HME technology in 2005. 2 These researchers used HME as an alternative technique for enteric delivery. Polyvinyl acetate phthalate and hydroxypropyl methyl cellulose acetate succinate (HPMC AS) enteric coating polymers were premixed with plasticizers and extruded into hollow cylinders. A model drug was then filled into these hollow cylinders and both open ends were sealed. Dissolution... [Pg.228]

Hydroxypropyl methylcellulose acetate succinate (HPMCAS), a cellulose ether ester derived from HPMC esterifled with acetate and succinate groups, is an enteric polymer soluble only in water of high pH or in polar organic solvents like acetone or tetrahydrofuran (THE). The enteric performance is due to the presence of carboxylic groups. At low pH, HPMCAS exists in its protonated... [Pg.519]

Friesen, D.T., Shanker, R., Crew, M., Smithey, D.T., Curatolo, W.J., Nightingale, J.A.S. Hydroxypropyl methyl-cellulose acetate succinate-based spray-dried dispersions An overview. Mol. Pharm. 2008,5(6), 1003-1019. [Pg.531]

Cellulose esters or ethers such as methylcellulose (MC), ethylcellulose (EC), hydroxyethyl cellulose (HEC), hydroxypropyl cellulose (HPC), hydroxypropyl methylcellulose/hypromellose (HPMC), hypromeUose phthalate (HPMCP), hypromellose acetate phthalate (HPMCAP), hypromellose acetate succinate (HPMCAS), cellulose acetate (CA) and derivates Poly (methyl) methacrylates (Eudragit L, S, E, RS/ RL)... [Pg.1139]

FIGURE 49.9 Schematic representation of foaming process (1) dissolution of gas into polymer, (2) cell nucleation, (3) cell growth and expansion, and (4) SEM of hydroxypropyl methyl cellulose acetate succinate (HPMCAS) extrudate foamed with nitrogen gas. [Pg.1143]


See other pages where Hydroxypropyl acetate succinate is mentioned: [Pg.516]    [Pg.40]    [Pg.424]    [Pg.43]    [Pg.333]    [Pg.448]    [Pg.1732]    [Pg.294]    [Pg.8]    [Pg.34]    [Pg.517]    [Pg.519]    [Pg.1143]    [Pg.333]    [Pg.437]    [Pg.437]    [Pg.708]   
See also in sourсe #XX -- [ Pg.63 , Pg.70 , Pg.71 , Pg.126 , Pg.138 , Pg.139 , Pg.145 , Pg.146 , Pg.152 , Pg.153 , Pg.311 , Pg.551 ]




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