Polyvinyl acetate phthalate

The USPNF 23 describes polyvinyl acetate phthalate as a reaction product of phthalic anhydride and a partially hydrolyzed polyvinyl acetate. It contains not less than 55.0% and not more than 62.0% of phthalyl (o-carboxybenzoyl, CsHjOs) groups, calculated on an anhydrous acid-free basis. [Pg.589]

It has been reported that the free phthalic acid content is dependent on the source of the material. [Pg.589]

Plasticizers are often included in polyvinyl acetate phthalate coating formulations to enable a continuous, homogeneous, noncracking film to be produced. Polyvinyl acetate phthalate has been shown to be compatible with several plasticizers such as glyceryl triacetate, triethyl citrate, acetyl triethylcitrate, diethyl phthalate and polyethylene glycol 400. [Pg.589]

Depending on the phthalyl content, a will vary with b in mole percent. The acetyl content c remains constant depending on the starting material. [Pg.589]

Polyvinyl acetate phthalate is a free-flowing white to off-white powder and may have a slight odor of acetic acid. The material is essentially amorphous. [Pg.589]

Polyvinyl acetate phthalate PVAP As above, if pH > 5.0 Dissolves along whole length of duodenum... [Pg.325]

Polyvinyl acetate phthalate (PYAP) dissolves at pH higher than 5 and is soluble in ethanol. Plasticizers that are used with PVAP include triethyl citrate, glyceryl triacetate, and acetyltriethyl citrate. [Pg.185]

Formulation with Polyvinyl Acetate Phthalate (PVAP) ... [Pg.1020]

Cellulose acetate hypromellose phthalate polyvinyl acetate phthalate. [Pg.146]

Table II Pharmacopeial specifications for polyvinyl acetate phthalate. ...

The characteristics of polyvinyl acetate phthalate from two sources have been compared values for molecular weight (60 700 47000), moisture content (3.74% 2.20%) and density (1.31 g/cm 1.37g/cm ) have been reported. The solubility of each polyvinyl acetate phthalate in a range of different solvents was described and scanning electron photomicrographs were produced to give evidence of the different polymer morphology. ... [Pg.590]

Glass transition temperature a glass transition temperature of 42.5°C has been reported for polyvinyl acetate phthalate the glass transition temperature was shown to fall with the addition of increasing amounts of the plasticizer diethyl phthalate. ... [Pg.590]

Solubility soluble in ethanol and methanol sparingly soluble in acetone and propan-2-ol practically insoluble in chloroform, dichloromethane, and water. In buffer solutions, polyvinyl acetate phthalate (200mg/L) is insoluble below pH 5 and becomes soluble at pH values above 5. Polyvinyl acetate pththalate shows a sharp solubility response with pH this occurs at pH 4.5-5.0, which is lower than for most other polymers used for enteric coatings. Solubility is also influenced by ionic strength. See Table III. [Pg.590]

Viscosity (dynamic) the viscosity of a solution of polyvinyl acetate phthalate methanol (1 1) is 5000 mPas. In metha-nol/dichloromethane systems, viscosity increases as the concentration of methanol in the system increases. [Pg.590]

Polyvinyl acetate phthalate reacts with povidone to form an insoluble complex that precipitates out of solution benzo-caine is also incompatible with polyvinyl acetate phthalate. Erythromycin disperses in polyvinyl acetate phthalate and has been shown to be physically stable while omeprazole exists in the amorphous form in polyvinyl acetate phthalate coatings with no evidence of interaction. ... [Pg.590]

Polyvinyl acetate phthalate is a reaction product of phthalic anhydride, sodium acetate, and a partially hydrolyzed polyvinyl alcohol. The polyvinyl alcohol is a low molecular weight grade, and 87-89 mole percent is hydrolyzed. Therefore, the polyvinyl acetate phthalate polymer is a partial esterification of a partially hydrolyzed polyvinyl acetate. [Pg.590]

Polyvinyl acetate phthalate is used in oral pharmaceutical formulations and is generally regarded as an essentially nonirritant and nontoxic material when used as an excipient. [Pg.590]

Polyvinyl acetate phthalate should be stored in airtight containers. It is relatively stable to temperature and humidity and does not age, giving predictable release profiles even after prolonged storage. [Pg.590]

At high temperature and humidity, polyvinyl acetate phthalate undergoes less hydrolysis than other commonly used enteric coating polymers. In aqueous colloidal dispersions of polyvinyl acetate phthalate, the formation of free phthalic... [Pg.590]

Polyvinyl acetate phthalate dissolves along the whole length of the duodenum. [Pg.590]

Nesbitt RU, Goodhart FW, Gordon RH. Evaluation of polyvinyl acetate phthalate as an enteric coating material. Int J Pharm 1985 26 215-226. [Pg.591]

Kumar V, Banker GS. Incompatibility of polyvinyl acetate phthalate with benzocaine isolation and characterization of 4-phthalimidobenzoic acid ethyl ester. Int J Pharm 1992 79 61-65. Sarisuta N, Kumpugdee M, Muller BW, Puttipipatkhachorn S. Physico-chemical characterization of interactions between erythromycin and various film polymers. Int J Pharm 1999 186 109-118. [Pg.591]

Cable C. Polyvinyl acetate phthalate. In Rowe RC, Sheskey PJ. Owen SC, eds. Pharmaceutical Excipients 5. Hiaimaceutical Press and American Pharmacists As.sociation, 2005. [Pg.409]

Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...