Amoxycillin trihydrate

Procedure Weigh accurately about 0.17 g of amoxycillin trihydrate and dissolve in sufficient DW to produce 500 ml. Now, transfer 10 ml of this solution into a 100 ml volumetric flask, add 10 ml of buffer solution pH 9.0 followed by 1 ml of acetic anhydride-dioxan solution, allow to stand for 5 minutes, and add sufficient water to produce 100 ml. Pipette 2 ml of the resulting solution into each of the two stoppered tubes. To tube 1 add 10 ml of imidazole-mercury reagent, mix, stopper the tube and immerse it in a water-bath previously maintained at 60 °C for exactly 25 minutes, with occasional swirling. Remove the tube from the water-bath and cool rapidly to 20 °C (Solution-1). To tube 2 add 10 ml of DW and mix thoroughly (Solution-2). Immediately, measure the extinctions of Solutions 1 and 2 at the maximum at about 325 nm, as detailed above, employing as the blank a mixture of 2 ml of DW and 10 ml of imidazole-mercury reagent for Solution-1 and simply DW for Solution-2. 

Calculations The content of C16H19N305S may be calculated from the difference between the extinctions of Solution-1 and that of Solution-2 and from the difference obtained by repeating the operation using 0.17 g of amoxycillin trihydrate (RS), instead of the sample being examined and the declared content of C16H19N305S in the amoxycillin trihydrate (RS). 

A number of organic compounds, such as N, N-dimethylaniline-present in amoxycillin trihydrate cephalexin cloxacillin sodium dicloxacillin sodium 2-ethylhexanoic acid-in amoxycillin sodium 4-chlorophenol-in clofibrate acetone and butanol-in daunorubacin hydrochloride cineole limonene ratio-in dementholised mint oil etc ... 

Part—IV has been entirely devoted to various Optical Methods that find their legitimate recognition in the arsenal of pharmaceutical analytical techniques and have been spread over nine chapters. Refractometry (Chapter 18) deals with refractive index, refractivity, critical micelle concentration (CMC) of various important substances. Polarimetry (Chapter 19) describes optical rotation and specific optical rotation of important pharmaceutical substances. Nephelometry and turbidimetry (Chapter 20) have been treated with sufficient detail with typical examples of chloroetracyclin, sulphate and phosphate ions. Ultraviolet and absorption spectrophotometry (Chapter 21) have been discussed with adequate depth and with regard to various vital theoretical considerations, single-beam and double-beam spectrophotometers besides typical examples amoxycillin trihydrate, folic acid, glyceryl trinitrate tablets and stilbosterol. Infrared spectrophotometry (IR) (Chapter 22) essentially deals with a brief introduction of group-frequency... 

Hilton, A. K., and Deasy, P. B. In vitro and in vivo evaluation of an oral sustained-release floating dosage form of amoxycillin trihydrate. Int. J. Pharm. 86 79-88, 1992. 

Infra-red Spectrum. Principal peaks at wavenumbers 1775,1583, 1684, 1248, 1613, 1313 (amoxycillin trihydrate, KBrdisk). 

Amotril, All Amotriphene, xvii Amoxapine, 348 (metabolite), 713 Amoxican, 348 Amoxicillin(e), 348 Amoxil, 348 Amoxycillin, 348 Amoxycillin sodium, 348 Amoxycillin trihydrate, 348 Amoxypen, 348 Amperil, 351 Amphetamine, 349 (metabolite), 386, 764, 969 (-)-Amphetamine, 701 Amphetamine phosphate, 349 Amphetamine sulphate, 349 Amphetamines, gas chromatography, 17, 193 high pressure liquid chromatography, 214 metabolism, 287 thin-layer chromatography, 169 Amphicol, 443 Ampho-Moronal, 350 Amphotericin, 350 Ampicillin, 351... 

Fig. 8 Release profiles of hard (A) and soft gelatin (B) capsules of amoxycillin trihydrate in unexposed condition and after exposure to 40°C/75% RH/light for 8 day. The soft gelatin capsules show more drastic fall in dissolution upon exposure than the hard gels.

Hilton AK, Deasy PB. Use of hydroxypropyl methylcellulose acetate succinate in an enteric polymer matrix to design controlled-release tablets of amoxycillin trihydrate. J Pharm Sci 1993 82 737-743. 

The intramuscular bioavailability of amoxycillin in pigs is 83%, based on intravenous injection of amoxycillin sodium and intramuscular injection of amoxycillin trihydrate 15% in oil (described as the conventional formulation) in the neck, 10 cm behind the ear, of pigs. The conventional formulation provides slow absorption of amoxycillin (MAT, 7.3 h), Cmax of 5.1 pg/mL and delays elimination of the drug (MRT .m. is 8.8 h compared with MRT .V. of 1.5 h). Administration of the long-acting formulation of amoxycillin trihydrate 15% in... 

Fig. 2.8 Effect of species and weight on the bioavailability of amoxycillin after intramuscular injection of amoxycillin trihydrate aqueous suspension (100mg/mL) at the same dose (7 mg/ kg) in the various species except cats (10-12mg/kg).

Effect of the injection site on the bioavailability of amoxycillin trihydrate in dairy cows. Journal of Veterinary Pharmacology and Therapeutics, 3,125-132. 

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