Tablet cores

The weight, hardness, thickness is measured to try and generate information about core consistency. An off-line HPLC test for potency carried out on ten samples selected as being representative of variability across the whole batch. The analysis of these samples is far too slow to be regarded as PAT. However 

In future this may be taken to the next step of 100% core testing and outlier rejection. At this point the process is not being simply controlled but the quality of every core is being measured by PAT. 

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Figure 7 Picture of an asymmetrical membrane coating layered onto a tablet core. (From Ref. 20.)...

Zentner and coworkers [24,26] utilized this information in their development of a system that releases this drug over a 24 hr period. The use of NaCl to modulate the release of diltiazem presents an interesting problem in that the concentration of the solubility modifier must be maintained within certain limits and below its saturation solubility within the device. To solve this problem, core formulations were developed that contained both free and encapsulated NaCl. The encapsulated NaCl was prepared by placing a microporous coating of cellulose acetate butyrate containing 20 wt% sorbitol onto sieved NaCl crystals. The coated granules released NaCl over 12-14 hr period via an osmotic mechanism into either water or the core tablet formulation. The in vitro release profile for tablets (core I devices) containing 360 mg of diltiazem HC1 and 100 mg of NaCl equally divided between the immediate release and controlled release fractions... 

Figure 2S Compression profiles of tablet cores made from ribbons compacted at three different forces.

Tablet core muat have certain conductive properties or be modified...

Radiant heat applied to fuse and fix the coating powder on to the tablet core... 

This PCA image study showed the differences between the two data sets, that is, it separated the good and bad dissolution samples. The main differences were due to the distribution of magnesium stearate and the API. No differences were observed in the spatial distribution of poloxamer or Avicel. Magnesium stearate is hydrophobic, thus protecting the tablet core from moisture and hence slowing dissolution. When a sample had more active ingredient on the surface, the dissolution properties were increased. 

The time required for complete disintegration will provide an indication of possible issues with the dosage unit that could affect the release of active ingredient (e.g., overcompression of capsule powders or tablet cores). 

Solvent (water) penetration into the tablet cores and, hence, product sta-... 

Tablet coating is done for a variety of reasons. The tablet core may contain an active substance that imparts undesirable organoleptic qualities to the tablet. The active moiety of the tablet may be unstable to specific environmental conditions and may need protection. The core may need to be coated to meet marketing requirements. The coating may be needed to impart enteric properties or sustained-release characteristics to the active release profile. Typical coating processes require a solvent, organic or aqueous. Utilities required include compressed air, steam, and electrical service. Provisions should be made for air handling. The exhaust system used must be capable of handling the solvent used in this process.

Tablet press subclasses primarily are distinguished from one another by the method that the powder blend is delivered to the die cavity. Tablet presses can deliver powders without mechanical assistance (gravity), with mechanical assistance (power assisted), by rotational forces (centrifugal), and in two different locations where a tablet core is formed and subsequently an outer layer of coating material is applied (compression coating).

In the case of formulation No. 1 it was not possible to press tablet cores of a biconvex form because some capping effect was observed. 

Garlic Extract + Thyme Extract Tablets Cores with Vitamin C (300 mg + 25 mg + 100 mg)... 

Multivitamin Tablet Cores with Beta-Carotene (1-2 RDA of Vitamins) page 2... 

These tablet cores could be coated with an enteric coating of Kollicoat MAE 30 D [1] (see chapter 3). 

Valeriana Extract + Passiflora Extract Tablet Cores (44 mg + 30 mg)... 

Prepare the two suspensions separately, mix, pass through a colloid mill and spray onto the tablet cores in a perforated coating pan (e.g. Accela Cota 24 inch) until a weight gain of 8 - 10% of the cores ist obtained. 

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