Humans pulmonary

Pignatti P, Brunetti G, Moretto D, et al. Role of the chemokine receptors CXCR3 and CCR4 in human pulmonary fibrosis. Am J Respir Crit Care Med 2006 173(3) 310—317. 

Pang JA, Butland RJA, Brooks N, Cattell M, Geddes DM (1982) Impaired lung uptake of propranolol in human pulmonary emphysema. Am Rev Respir Dis 125 194-198. 

Calu-3 cells have shown the ability to perform fatty acid esterification of budes-onide [132], In pre-clinical studies, this esterification results in a prolonged local tissue binding and efficacy, which is not found when the esterification is inhibited [133]. The precise mechanism remains undefined in that the identity of specific enzyme(s) responsible for this metabolic reaction is unclear [134], Assessment of the potential toxicity and metabolism of pharmaceuticals and other xenobiotics using in vitro respiratory models is still at its infancy. The development of robust in vitro human models (i.e., cell lines from human pulmonary origin) has the potential to contribute significantly to better understanding the role of biotransformation enzymes in the bioactivation/detoxication processes in the lung. 

Hukkanen J, Pelkonen O, Raunio H (2001) Expression of xenobiotic-metabolizing enzymes in human pulmonary tissue possible role in susceptibility for ILD. Eur Respir J Suppl 32 122s-l26s... 

Hazucha, M., and D. V. Bates. Combined effect of ozone and sulphur dioxide on human pulmonary function. Nature 257 50-51, 1975. 

Autrup, H., C. C. Harris, G. D. Itmer, J. K. Selkirk, P. M. Scafer, and B. F. Trump (1978). Metabolism of [ H] bezo(a)p)frene by cultured human bronchus and cultured human pulmonary alveolar macrophages. Lab. Invest. 38 217-224. 

Kuschner WG, Wong H, D Alessandro A et al Human pulmonary responses to experimental inhalation of high concentration fine and ultrafine magnesium oxide particles. Environ Health Perspect 105(11) 1234—1237, 1997... 

Soslow RA, Dannenberg AJ, Rush D, et al. COX-2 is expressed in human pulmonary, colonic, and mammary tumors. Cancer 2000 89 2637-2645. 

Raithel HJ, Schaller KH, Akslen LA, et al. 1989. Analyses of chromium and nickel in human pulmonary tissue. Investigations in lung cancer patients and a control population under special consideration of medical expertise aspects. Int Arch Occup Environ Health 61 507-512. 

McCormack DG, Clarke B, Barnes PJ (1989) Characterization of adenosine receptors in human pulmonary arteries. Am J Physiol 256(2) H41-H46 McWhinney CD, Dudley MW, Bowlin TL, Peet NP, Schook L, Bradshaw M, De M, Borcherding DR, Edwards CK 3rd (1996) Activation of adenosine A3 receptors on macrophages inhibits tumor necrosis factor-alpha. Eur J Pharmacol 310(2-3) 209-216 Mentzer RM Jr, Rubio R, Berne RM (1975) Release of adenosine by hypoxic canine lung tissue and its possible role in pulmonary circulation. Am J Physiol 229(6) 1625-1631 Meyerhof W, Mtiller-Brechlin R, Richter D (1991) Molecular cloning of a novel putative G-protein coupled receptor expressed during rat spermiogenesis. FEBS Lett 284(2) 155-160... 

Calvopina, M., Cuderian, R.H., Paredes, W.Y. and Cooper, P.J. (2003) Comparison of two single-day regimes of tridabendazole for the treatment of human pulmonary paragonimiasis. Transactions of the Royal Society of Tropical Medicine and Hygiene 97, 451 154. 

Birukova, A. A., Adyshev, D., Gorshkov, B., Bokoch, G. M., Birukov, K. G., and Verin, A. D. (2006). GEF-H1 is involved in agonist-induced human pulmonary endothelial barrier dysfunction. Am.J. Physiol. LungCellMol. Physiol. 290, L540-L548. 

Scanning electron microscopy (SEM) in concert with x-ray energy spectrometry (XES) has been used to detect silver in pulmonary, lacrimal sac, and skin tissues of individuals with diffuse interstitial lung disease, chronic dacryocystitis, and skin disorders, respectively (Brody et al. 1978 Loeffler and Lee 1987 Tanita et al. 1985). Brody et al. (1978) observed particles of preselected lesions of human pulmonary tissue magnified to 300x by SEM, and the silver content was analyzed by XES. The authors noted that SEM and XES techniques permit a rapid and conclusive determination of silver, silver compounds, and complexes in tissue lesions. 

Figure 12.9 Endothelial cell-specific nuclear import of plasmids. Growth-arrested African Green Monkey kidney epithelial cells (TC7), human pulmonary artery smooth muscle cells (HSMCs) and human umbilical vein endothelial cells (HUYECs) were microinjected in the nucleus (top) and cytoplasm with CMV-driven, GFP-expressing plasmids containing either no additional sequences (open bars), the SV40 enhancer (striped bars), or the flk-1 promoter (shaded bars). Eight hours after injection, the cells were visualized for GFP expression by fluorescence microscopy. Whereas all three plasmids supported GFP expression when delivered into the nucleus of all three cell types, only the SV40 enhancer mediated nuclear import and gene expression in all cells when injected into the cytoplasm. As predicted, the flk-1 promoter caused import and expression only in cells in which transcription factors necessary for its expression and import were made, namely endothelial cells.

Monkey kidney epithelial cells (TC7), human pulmonary artery smooth muscle cells... 

Golovina, V. A., Platoshyn, O., Bailey, C. L., Wang, J., Limsuwan, A., Sweeney, M., Rubin, L. J. and Yuan, J. X., 2001, Upregulated TRP and enhanced capacitative Ca(2+) entry in human pulmonary artery myocytes during proliferation. Am J Physiol Heart Circ Physiol 280, H746-55. 

Ullmer C, Boddeke HG, Schmuck K, Lubbert H. 5-HT2B receptor-mediated calcium release from ryanodine-sensitive intracellular stores in human pulmonary artery endothelial cells. Br J Pharmacol 1996 117 1081-1088. 

Hsu, I.C., C.C. Harris, M. Yamaguchi, B.F. Trump, and P.W. Schafer. Induction of ouabain-resistant mutation and sister chromatid exchanges in Chinese hamster cells with chemical carcinogens mediated by human pulmonary macrophages. J. Clin. Invest. 64 1245-1252, 1979. 

Raithel HJ, Ebner G, Schaller KH. 1987. Problems in establishing norm values for nickel and chromium concentrations in human pulmonary tissue. Am J Ind Med 12 55-70. 

TABLE 27.4. Pulmonary Tumor Response of Laboratory Rodents to Inhalation of Known Human Pulmonary Carcinogens... 

Sidobre, S., Nigou, J., Puzo, G., and Riviere, M., 2000, Lipoglycans are putative ligands for the human pulmonary surfactant protein A attachment to mycobacteria. J. Biol. Chem. 275 2415-2422. 

Lee, P.J., Alam, J., Wiegand, G.W., Choi, A.M. (1996). Overexpression of heme oxygenase-1 in human pulmonary epithelial cells results in cell growth arrest and increased resistance to hyperoxia. Proc. Natl Acad. Sci. USA 93 10393-8. 

OSH A PEL TWA 0.002 mg(Pt)/m3 ACGIH TLV TWA 0.002 mg(Pt)/m3 SAFETY PROFILE Poison by inhalation and ingestion. Human pulmonary system effects by inhalation. See also PLATINUM COMPOUNDS. An explosively unstable compound. Incompatible with KOH (boiling with alkah yields a product which, after drying, wiU explode 205° or if mixed with combustibles). When heated to decomposition it emits very toxic fumes of cr, NOx, and NH3. 

DOT CLASSIFICATION 8 Label Corrosive SAFETY PROFILE Moderately toxic by ingesdon. Human pulmonary system effects by inhaladon. Corrosive by vigorous reacdon with moisture, generadng heat and hydrogen chloride gas (a strong irritant), which can cause pulmonary edema when inhaled. Systemic effects can be caused by the andmony. See also ANTIMONY COMPOUNDS. Experimental reproducdve effects. Mutadon data reported. When heated to decomposidon it emits very toxic fumes of chlorine and andmony. It can react violendy with aluminum, potassium, sodium. 

DOT CLASSIFICATION 9 Label CLASS 9 SAFETY PROFILE Confirmed human carcinogen producing lung tumors. Experimental neoplastigenic and tumorigenic data. Human pulmonary system effects by inhalation. Usually at least 4 to 7 years of exposure are required before serious lung damage (fibrosis) results. Mutation data reported. A common air contaminant. 

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