Arrest cell growth

Courage C, Budworth J, Gescher A (1995) Comparison of ability of protein kinase C inhibitors to arrest cell growth and to alter cellular protein idnase C localisation. Br J Cancer 71 697-704... 

The arrest of cell growth by many agents is associated with depletion of one or more of the deoxyribonucleotide pools. Thus, thymidine at millimolar concentrations arrests cell growth and decreases the concentration of dCTP dramatically, whereas the concentrations of dATP, dGTP, and... 

In summary, gossypol is believed to arrest cell growth at the Go/Gi phase and induce cell apoptosis, in cancer cells, by regulating the cell cycle, enzymes, antiapoptosis, and proapoptosis proteins. 

Sulforaphane has been shown to induce both apoptosis and cell cycle arrest in several cell lines, including HT29 human colon cancer cells [56], LNCaP human prostate cancer cells [57], and Jurkat human T-leukemia cells [58]. Incubation of such cells with 3-30 pM SF for 24-48 hours resulted in a dose-dependent induction of apoptosis and cell cycle arrest, showing that this compound can induce apoptosis and arrest cell growth and suggesting that this activity is unlikely to be cell type specific. There is also evidence that the concentration of SF required to induce apoptosis and cell cycle arrest may be much... 

The anticancer effect of milk thistle has equally been investigated in numerous animal models and in human patients. Silybin was found to arrest cell growth and progression of lung and prostate tumors in mice and rats," and to inhibit human hepatocellular, prostate. 

Edgar The endoreplication cycles might be a better example of growth-limited cycles. Christian Lehner has done experiments in which cyclin E is overexpressed in endoreduplicating cells. They get stuck in Gl. We have then expressed Myc in these Gl-arrested cells it doesn t make them grow much. They absolutely require endoreplication for growth. 

In the initial studies with pure antiestrogens, both ICI 164384 and fulvestrant inhibited cell growth and arrested the cell cycle in the Gi phase. These effects were two orders of magnitude more potent than those achieved with tamoxifen in the same experimental conditions (Wakeling and Bowler 1987). 

Pharmaceuticals represent a major class of treatments for a broad array of human diseases. These chemicals are isolated from nature or, more often, synthesized chemically. They are administered to patients to kill or arrest the growth of cancer cells or infectious microbes, to stimulate faltering hearts, and to achieve a host of other specific clinical aims. It is widely recognized that not all people respond alike to these therapies, even when the diagnosis is quite specific. 

For monolayer cultures, the cultures are set up the day before BrdU treatment so that the cells will be in exponential growth before the addition of BrdU or the test compound. After BrdU addition the cells are allowed to undergo the equivalent of two cell cycles before cell harvest. A spindle inhibitor such as colchicine or colcemid is introduced for the final 1-2 h of culture to arrest cells in metaphase, after which the cells are harvested and chromosome preparations are made by routine cytogenetic techniques. 

Normally, a cell grows by cell division and then dies through a process called apoptosis— programmed cell death. The p53 protein triggers apoptosis, which is a stop signal for cell division, to arrest cancer growth. 

Qiacko et al, 1996). Cell growth is arrested when the type II Fey receptor bl (FcyRIIbl) associates with the B ceU receptor (BCR) by the interaction of their extracellular domains with immune complexes. Clustering FcyRIIbl with BCR induces the phosphorylation of the immimoreceptor tyrosine-based inhibitory motif (ITIM) within the FcyRIIb intracellular tail, which then allows SHIP to bind through its SH2 domain. Recruitment of SHIP to the cell membrane by FcyRIIb p-ITIM is believed to block extracellular uptake and cell growth via the inositol 5-phosphatase activity of SHIP. 

Shammas MA, Reis RJS, Cheng L, Koley H, Hurley LH, Anedrson KC, Munshi NC (2004) Telomerase inhibition and cell growth arrest after telomestatin treatment in multiple myeloma. Chn Cancer Res... 

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