Pulmonary tumors

Stoner GD, Shimkin MB, Troxell MC, et al. 1976. Test for carcinogenicity of metallic compounds by the pulmonary tumor response in strain A mice. Cancer Res 36 1744-1747. 

Equivalent to 0.73 mg/m3 for 78 weeks plus 30 weeks of postexposure observation exposure Pulmonary tumor growth (14% incidence in lung tumors vs. 1% in controls) and increased mortality (95% dead vs. 69% in controls) 6, 25... 

Sunderman, F.W., Jr. and A.J. Donnelly. 1965. Studies of nickel carcinogenesis metastasizing pulmonary tumors in rats induced by the inhalation of nickel carbonyl. Amer. Jour. Pathol. 46 1027-1041. 

In a chronic inhalation study conducted by NTP (1982), carcinogenic end points were nasal tumors in rats and mice and pulmonary tumors in mice (see Section 2.2.1.8). A nonneoplastic lesion of epithelial hyperplasia occurring throughout the respiratory tract was a prominent histologic feature in the 1,2-dibromoethane-exposed mice. 

Maronpot RR, Shimkin MB, Witschi HP, et al. 1986. Strain A mouse pulmonary tumor test results for chemical previously tested in the National Cancer Institute carcinogenicity tests. J Natl Cancer Inst 76 1101-1112. 

Pulmonary tumors," may impair some vascular endothelial functions and alter the interaction between platelet and endothelial mediators ... 

Some animal studies with ozone or thetic photochemical smog have shown chromosomal defects in circulating lymphocytes, a more rapid appearance of benign pulmonary tumors, and an increase in neonatal mortality consistent with a mutagenic effect. 

Kotin, P., and H. L. Falk. 11. The experimental induction of pulmonary tumors in strain-A mice after their exposure to atmosphere of ozonized gasoline. Cancer 9 910-917, 1956. 

Maronpot RR, Witschi HP, Smith LH, et al. 1983. Recent experience with the strain A mouse pulmonary tumor bioassay model. Environ Sci Res 27.341-345. 

The carcinogenicity of ethylenimine has been investigated in animal studies. Rats given subcutaneous injections twice weekly for 33 weeks developed sarcomas at the injection site. Administered to mice by gavage for 3 weeks, followed by dietary administration for 77 weeks, it caused a significant increase in hepatomas and pulmonary tumors. ... 

Poirier LA, Stoner GD, Shimkin MB Bioassay of alkyl halides and nucleotide base analogs by pulmonary tumor response in Strain A mice. Cancer Res 35(6) 1411-1415, 1975... 

Carcinogenesis Isoniazid induces pulmonary tumors in a number of strains of mice. Pregnancy Category C. 

White, J. F. Foley, R. R. Maronpot, and NT108 M. W. Anderson. Role of Clara cells and type II cells in the development of pulmonary tumors in rats and mice following exposure to a tobacco-specific nitrosamine. Exp Lung Res 1991 ... 

Pulmonary Tumors in Animals after 20 Inhalation Exposures to Various Chemicals8... 

Kotin, P., H. L. Falk, and G. J. McCammon, The Experimental Induction of Pulmonary Tumors and Changes in the Respiratory Epithelium in C57B1 Mice Following Their Exposure to an Atmosphere of Ozonized Gasoline, Cancer, 11, 473-481 (1958). 

Nishizuka, Y., Nakakuki, K., and Sakakura, T. (1964). Induction of pulmonary tumors and leukemia by a single injection of 4-nitroquinoline 1-oxide to newborn and infant mice, Garm 55,495. 

Shimkin, M.B., Weisburger, J.H., Weisburger, E.K., Gubareff, N. Suntzeff, V. (1966) Bioassay of 29 alkylating chemicals by the pulmonary-tumor response in strain Amice. J. natl Cancer /rat., 36, 915-935... 

Theiss, J.C., Stoner, G.D., Shimkin. M.B. Weisburger, E.K. (1977) Test for carcinogenicity of organic contaminants of United States drinking waters by pulmonary tumor response in strain Amice. Cancer Res., M, T1 L-TT2.Q... 

Most pulmonary tumor colonies in mice are in the pleura. Therefore, pigmented colonies (such as melanomas) can be counted without lung dissection. However, it may be more facile, especially when there are extensive pulmonary metastases, to dissect the lungs into the individual four or five lobes which are then enumerated individually using a dissecting microscope. 

Shimkin MB, Leiter J. 1940. Induced pulmonary tumors in mice. III. The role of chronic irritation in the production of pulmonary tumors in strain A mice. J Natl Cancer Inst 1 241-254. 

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