Human Papillomavirus HPV

In addition to this, the potential of producing a plant-made vaccine against a papillomavirus using a virus-based vector has been explored. In this case, the LI capsid protein of control rabbit papillomavirus (CRPV), a model system for the study of papillomavirus-host interactions, was 

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Genital warts, caused by the human papillomavirus (HPV), are regularly encountered in primary care. Responsible for various visible, keratotic, and non-keratotic manifestations, HPV has nearly 120 noted strains, some of which have been linked to squamous cell carcinoma.20... 

A CL ISH assay for the detection of human papillomavirus (HPV) DNA was developed, in which the hybridization reaction was performed using either digoxigenin-, biotin-, or fluorescein-labeled probes [64], The hybrids were visualized using AP as the enzyme label and a highly sensitive 1,2-dioxetane phosphate as chemiluminescent substrate. This assay was applied to biopsy specimens from different pathologies associated with HPV, which had previously proved positive for HPV DNA by polymerase chain reaction (PCR). The analytical sensitivity was assessed using samples of HeLa and CaSki cell lines, whose content in HPV DNA is known (10-50 copies of HPV 18 DNA in HeLa cells and 400-600 copies... 

A new subunit recombinant vaccine is Gardasil it is a tetravalent vaccine against human papillomavirus (HPV) implicated in cervical cancer. See Exhibit 4.5 for details. 

Gardasil is a noninfectious recombinant vaccine consisting of capsid proteins from four different human papillomaviruses (HPVs) of types 6,11, 16, and 18. HPV causes squamous cell cervical cancer and cervical adenocarcinoma, as well as 35-50% of vulvar and vaginal cancers. 

Human papillomavirus (HPV) infection is a necessary factor in the development of nearly all cases of cervical cancer. A recently approved HPV vaccine, Gardasil, that blocks initial infection with several of the most common sexually transmitted HPV types may lead to significant decreases in the incidence of HPV-induced cancer (see Lowy et ah, 2006). 

Human papillomavirus (HPV) is the causative agent of virtually all cases of cervical cancer and one of the most common of the sexually transmitted diseases. Cervical cancer remains a main cause of cancer-related death in many developing countries. Current vaccines are too expensive... 

Imiquimod is an immune response modifier shown to be effective in the topical treatment of external genital and perianal warts (ie, condyloma acuminatum see Chapter 62 Dermatologic Pharmacology). The mechanism of action against these human papillomavirus (HPV)-induced lesions is unknown. The 5% cream is to be applied three times weekly. Local skin reactions are the most common side effect. 

ASOs have been administered by many of these routes - generally with marked success even with the shorter half-life first-generation oligonucleotide chemistries. Besides Vitravene for CMV retinitis, first-generation ASOs have also been administered locally for ulcerative colitis (rectal), human papillomavirus (HPV) infec-... 

Muderspach, L., Wilczynski, S., Roman, L., et al. (2000) A phase I trial of a human papillomavirus (HPV) peptide vaccine for women with high-grade cervical and vulvar intraepithelial neoplasia who are HPV 16 positive. Clin. Cancer Res. 6, 3406-3416. 

Several DNA viruses are associated with, and are important in, the etiology of certain human cancers. For example, chronic infection with hepatitis B or C virus (HBV, HCV) is associated with liver cancer, infection with human papillomavirus (HPV) type 16 and type 18 is associated with cervical cancer, and infection with Epstein-Barr virus (EBV) is associated with Burkitt s lymphoma. About one-fifth of human cancer worldwide is associated with DNA oncogenic viruses. In 2006, the FDA approved a vaccine against HPV 16 and 18, which are responsible for about 70% of cervical cancer cases. 

Cervical cancer, human papillomaviruses (HPVs) and, 22 Channel catfish virus, 381 CHEF sheet, 128... 

Human papillomaviruses (HPV) comprise a genus in the species Papovaviridae, which consist of small, naked icosahedral viruses containing circular dsDNA. HPV types 16 and 18 infect squamous epithelium of the genitalia and may infect as many as 45% of the female population in developed countries (1). 

Indications Prevention of Human Papillomavirus (HPV) types 16 and 18 in females aged 10 to 45 years old Category Vaccine Half-life 4.5 years... 

Verrucas and warts are horny projections of skin, usually on the hands and feet, caused by the human papillomavirus (HPV). 

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