Calcium regulator

Therapeutic Function Calcium Regulator, Vitamin D Chemical Name 9,10-Secocholesta-5,7,10(19)-triene-1,3-diol Common Name la-Hydroxycholecalciferol 1a-Hydroxyvitamin D3 Structural Formula ... 

Blinks, J. R. (1989). Use of calcium-regulated photoproteins as intracellular Ca2+ indicators. Method. Enzymol. 172 164-203. 

Deng, L., et al. (2002b). The crystal structure of the calcium-regulated photoprotein obelin from Obelia geniculata. Luminescence 17 87-88. 

Vysotski, E. S., etal. (1999). Preparation and preliminary study of crystals of the recombinant calcium-regulated photoprotein obelin from the biolu-minescent hydroid Obelia longissima. Acta Cryst. D55 1965-1966. 

McNiven, M.A., Ward, J.B. (1988). Calcium regulation of pigment transport in vitro. J. Cell Biol. 106, 111-125. 

Pathogenesis of MH is not completely understood. Skeletal muscle, however, is the one tissue in MH with proven abnormalities, and it is further thought that the basic defect that causes the syndrome lies in the calcium regulation system found within the myoplasm. For example, calcium transport function appears to be decreased in the sarcoplasmic reticulum, mitochondria, and sarcolemma. Thus, the suggestion has been made that MH is characterized by a generalized membrane defeet. 

Fernandez-Chacon, R., Konigstorfer, A, Gerber, S. H. et al. Synaptotagmin I functions as a calcium regulator of release probability. Nature 410 41-49, 2001. 

Once apoptosis is triggered, a stereotyped sequence of premitochondrial events occurs that executes the cell death process. In many cases proteins and/or lipid mediators that induce changes in mitochondrial membrane permeability and calcium regulation are produced or activated. For example, the pro-apoptotic Bcl-2 family members Bax, Bad and Bid may associate with the mitochondrial membrane and modify its permeability. Membrane-derived lipid mediators such as ceramide and 4-hydroxynonenal can also induce mitochondrial membrane alterations that are critical for the execution of apoptosis. 

Chief, Calcium Regulation Section National Institute of Environmental Health Sciences National Institutes of Health PO Box 12233 (MD F2-02)... 

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