Human keratinocytes cell lines

Van Och, F.M. et al., Assessment of potency of allergenic activity of low molecular weight compounds based on IL-1 alpha and IL-18 production by a murine and human keratinocyte cell line, Toxicology, 210, 95, 2005. 

Boukamp, P., R. T. Petrussevska, D. Breitkreutz, J. Homung, A. Markham, and N. E. Fusenig. 1988. Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J Cell Biol 106(3) 761-71. 

Hudson LG, Toscano WA Jr, Greenlee WF. 1985. Regulation of epidermal growth factor binding in human keratinocyte cell line by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol 77 251-259. 

Doxycycline inhibits the detachment of SM-exposed HaCaT cells in culture from the growth substrate. However, analysis of the metabolic activity of the adherent cells reveals that doxycycline treatment does not maintain cell viability. It is suggested that doxycycline and other matrix metalloprotease inhibitors may have a role to play in therapeutic intervention against SM, only as a combination therapy (Lindsay et al, 2007). Human keratinocyte cell lines were pretreated with mixtures of methenamine and glutathione prior to SM exposure. Though it is possible to protect the cell cultures from the toxic effects of SM, it will be effective only as a pretreatment (Smith et al, 1997). 

In the naphthoquinone group, a number of lapacho compounds, the most common naphthoquinonic constituents of the inner bark of Tabebuia impetiginosa (Mart ex D C.) Standi were evaluated in vitro against the growth of the human keratinocyte cell line HaCaT. All compounds inhibited keratinocyte growth and appear to be promising as effective antipsoriatic agent [147],... 

Frericks M, Burgeon LD, Zacharewski TR, Esser C (2008) Promoter analysis of TCDD-inducible genes in a thymic epithelial cell line indicates the potential for cell-specific transcription factor crosstalk in the AhR response. Toxicol Appl Pharmacol 232 268-279 Gaido KW, Maness SC, Leonard LS, Greenlee WF (1992) 2, 3,7, 8-Tetrachlorodibenzo-p-dioxin-dependent regulation of transforming growth factors-alpha and -beta 2 expression in a human keratinocyte cell line involves both transcriptional and post-transcriptional control. J Biol Chem 267 24591-24595... 

Venner T. J., Sauder, D, N., Feliciani,C., Mckenzie,R. C. (1995) Interleukin-8 and melanoma growth-stimulating activity (GRO) are induced by ultraviolet B radiation in human keratinocyte cell lines. Exp. Dermatol. 4,138-145. 

Evidences indicate that keratinocytes and dendritic cells present sensitizer-specific receptors capable of recognizing allergens and irritants [53, 54]. Human keratinocyte cell lines are induced to secrete reactive oxygen species [ROS] and nitrogen species after the addition of allergens and irritants in the culture indicating that oxidative stress is a related process [55, 56]. 

Usnic acid Methyl a-orcinolcarboxylate Ethyl hematommate Diffractaic acid (+) Protolichesterinic acid Human keratinocyte cell line HaCaT Kumar and Muller (1999)... 

Protolichesterinic acid Aliphatic and cycloaliphatic APP 5-lipoxygenase Antiproliferative activity Cytotoxic activity Antimicrobial activity Antimycobacterial activity Inhibition of DNA polymerase activity Inhibitor of human keratinocyte cell line et al. (1964) Ingolfsdottir et al. (1994, 1997a, 1998, 2000) Ogmundsdottir et al. (1998) Turk et al. (2003) Haraldsdottir et al. (2004)... 

Diploicin (77) Cytotoxic against B16 (murine melanoma) and HaCaT (human keratinocyte) cell lines Buellia canescens (Dicks.) De Not. [99]... 

The cytotoxicity of diploicin (77) was evaluated by Millot and coworkers in 2009 against B16 (murine melanoma) and HaCaT (human keratinocyte) cell lines [100]. Pannarin (66), a secondary metabolite from lichen Diploicia canescens, was tested by two different research groups for its inhibitory potential against DU-145 prostate carcinoma [100] and M14 (human melanoma) cell lines with positive results [96]. Recently, the cytotoxicity of proto-lichesterinic acid (8) against HeLa cell lines has been evaluated by Brisdelli and coworkers. Its activity is based on its abdity to induce cell death through activation of caspases-3, -8, and -9 [101]. 

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