Therapeutic interventions

It is clear that free radical reactions are amongst the panoply of mechanisms leading to human cancers and this presents opportunities for intervention to prevent the processes of initiation, promotion or progression. Certainly there is 

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Masters CL Beyreuther K (2006). Alzheimer s centennial legacy prospects for rational therapeutic intervention targeting the AB amyloid pathway. Brain 129 2823-2839... 

As a result of such studies hypertension has been operationally defined as the blood pressure level above which therapeutic intervention has clinical benefit. As increasingly aggressive intervention has continued to demonstrate benefits, this level has gradually reduced over time and is commonly defined as systolic blood pressure>l40 mmHg and/or diastolic blood pressure >90 mmHg (Table 1). Isolated systolic hypertension is defined as systolic blood pressure >140 mmHg and diastolic blood pressure <90 mmHg. 

Emilien G, Maloteaux J-M, Geurts M et al (1999) Dopamine receptors—physiological understanding to therapeutic intervention potential. Pharmacol Ther 84 133-156... 

MMPs for therapeutic interventions is complicated by the fact that MMPs are indispensable for normal development and physiology and by their multifunctionality, possible functional redundancy or contradiction, and context-dependent expression and activity. This complexity was revealed by previous efforts to inhibit MMP activity in the treatment of cancer patients that yielded unsatisfactory results. Doxycycline, at subantimicrobial doses, inhibits MMP activity, and has been used in various experimental systems for this purpose. It is used clinically for the treatment of... 

Stetler-Stevenson WG (1999) Matrix metalloproteinases in angiogenesis a moving target for therapeutic intervention. J Clin Invest 103 1237-1241... 

Zeitzer JM, Nishino S, Mignot E (2006) The neurobiology of hypocretins (orexins), narcolepsy and related therapeutic interventions. Trends Pharmacol Sci 27 368-74... 

These insights into the structure of sleep and the neurobiological processes underlying it have yielded several targets for therapeutic intervention and provided novel methods by which to assess the differential effects of hypnotics on sleep-relevant neural circuits. 

Active devices intended to emit ionizing radiation and intended for diagnostic and therapeutic interventional radiology including devices which control or monitor such devices, or which directly influence their performance, are in Class lib. 

Post-inflammatory hyperpigmentation (PIH) is the acquired presence of darker macules and patches of skin occurring at sites of previous cutaneous inflammatory conditions. The processes preceding the altered skin color include mechanical injuries, allergic reactions, primary inflammatory skin disorders, and therapeutic interventions. 

Finding Targets for Therapeutic Intervention Bioinformatics and Vaccine Discovery Challenges... 

As illustrated in Table 43-5, the discovery of the nuclear receptor superfamily has led to an important understanding of how a variety of metabolites and xenobi-otics regulate gene expression and thus the metabolism, detoxification, and elimination of normal body products and exogenous agents such as pharmaceuticals. Not surprisingly, this area is a fertile field for investigation of new therapeutic interventions. 

Johnson Z, Proudfoot AE, Handel TM (2005) Interaction of chemokines and glycosaminoglycans a new twist in the regulation of chemokine function with opportunities for therapeutic intervention. Cytokine Growth Factor Rev 16 625-636 Jones G, Power C (2006) Regulation of neural cell survival by HIV-1 infection. Neurobiol Dis 21 1-17... 

With modest impairment of blood flow, this mechanism allows for preservation of oxidative metabolism without alteration in electrical function. However, when CPP and therefore CBF are sufficiently low, OEF reaches a maximum and cannot increase further. Brain tissue ceases to function electrically, resulting in a neurologic deficit. Microvascular collapse occurs, and CBV falls. If the oxygen supply falls low enough, the tissue dies. Of critical clinical importance is the observation that the amount of time it takes for tissue to suffer irreversible damage is inversely related to the severity of the ischemic insult. Tissue that is completely deprived of blood will die within a few minutes, but less severely hypoperfused tissue may survive for many hours, and may be saved by timely thrombolysis that restores perfusion, or perhaps by another therapeutic intervention. 

Davis, RE, Emmerling, MR, Jaen, JC, Moos, WH and Spiegel, K (1993) Therapeutic intervention in dementia. Crit. Rev. Neurobiol. 7 41-83. 

Therapeutic Interventions in Human Inflammatory Diseases - A Cautionary Note 108... 

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