Human melanoma

Villa R., Folini M., Lualdi S., Veronese S., Daidone M.C., Zaffaroni N. Inhibition of telomerase activity by a cell-penetrating peptide nucleic acid construct in human melanoma cells. FEB.S. Lett. 2000 473 241-248. 

Bolton, J. L. Pisha, E. Shen, L. Krol, E. S. Iverson, S. L. Huang, Z. van Breemen, R. B. Pezzuto, J. M. The reactivity of o-quinones which do not isomerize to quinone methides correlates with alkylcatechol-induced toxicity in human melanoma cells. Chem.-Biol. Interact. 1997, 106, 133-148. 

Robledo MM, Bartolome RA, Longo N, et al. Expression of functional chemokine receptors CXCR3 and CXCR4 on human melanoma cells. J Biol Chem 2001 48 45098—45105. 

Another potential source of iron, at least for hepatocytes, is receptor-independent uptake of iron from transferrin. This appears to involve an iron uptake pathway from transferrin which is neither suppressed in hepatocytes by antibodies to TfR (Trinder et at, 1988), nor by transfection of HuH-7 hepatoma cells with transferrin receptor anti-sense cDNA (Trinder etat, 1996). The same pathway may also be utilized for iron uptake from isolated transferrin N-lobe, which is not recognized by the receptor (Thorstensen et at, 1995). The possible role of TfR2 in this process remains to be established, as does the physiological importance of this pathway in intact liver. Human melanoma cells (Richardson and Baker, 1994) and Chinese hamster cells lacking transferrin receptors but transfected with melanotransferrin (Kennard et at, 1995) use another pathway for transferrin iron uptake, independent of the transferrin receptor, but utilizing iron transfer from transferrin or simple iron chelates to membrane-anchored melanotransferrin, and from there onwards into the cellular interior. 

Besch R, Poeck H, Hohenauer T, Senft D, Hacker G, Berking C, Homung V, Endres S, Ruzicka T, Rothenfusser S, Hartmann G (2009) Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon-independent apoptosis in human melanoma cells. J Clin Invest 119 2399-2411... 

The importance of superoxide-mediated damage to cancer cells was also demonstrated in the experiments with overexpressed mitochondrial MnSOD. Hirose et al. [186] showed that the overexpression of mitochondrial MnSOD enhanced the survival of human melanoma cells exposed to cytokines IL-1 and TNF-a, anticancer antibiotics doxorubicin and mitomycin C, and y-irradiation. Similarly, Motoori et al. [187] found that overexpression of MnSOD reduced the levels of reactive oxygen species in mitochondria, the intracellular production of 4-hydroxy-2-nonenal, and prevented radiation-induced cell death in human hepatocellular... 

Recently, a number of factors have been described that appear to be primarily motility factors (G3). These include scatter factor, a peptide produced by fibroblasts autocrine motility factor (AMF), a peptide originally purified from human melanoma cells and migration-stimulating factor (MSF), a peptide synthesized by embryo and certain tumor-associated fibroblasts. While both AMF... 

B7. Birch, M., Mitchell, S., and Hart, I. R., Isolation and characterization of human melanoma cell variants expressing high and low levels of CD44. Cancer Res. 65, 6160-6167 (1991). 

K8. Kirchheimer, J. C., Wojta, J., Christ, G., and Binder, B. R., Functional inhibition of endogenously produced urokinase decreases cell proliferation in a human melanoma cell line. Proc. Natl. Acad. Sci. U.S.A. 86, 5424-5428 (1989). 

K. Breisutl. H. R. Hendriks, 0. Fodstad, Superior Therapeutic Efficacy of A-L-Leucyl-doxorubicin versus Doxorubicin in Human Melanoma Xenografts Correlates with Higher Tumour Concentration of Free Drug , Eur. J. Cancer 1999, 35, 1143- 1149. 

Yang, H. M., and Reisfeld, R. Doxorubicin conjugated with a monoclonal antibody directed to a human melanoma-associated proteoglycan suppresses the growth of established tumor xenografts in nude mice, Proc. Natl. Acad. Sci. U.S.A., 1988, 85, 1189-1193. 

Pisha E, Chai H, Lee I-S, Chagwedera TE, Farnsworth NR, Cordell GA, Beecher CWW, Fong HHS, Kinghom AD, Brown DM, Wani MC, Wall ME, Hieken TJ, Das Gupta TK, Pezzuto JM. (1995) Discovery of betuhnic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis. Nat Med 1 1046-1051. 

Landthaler, M. and Stolz, W. (1999) Deficiency of a novel retinoblastoma binding protein 2-homolog is a consistent feature of sporadic human melanoma skin cancer. Laboratory Investigation ... 

Alteplase Alteplase is a drag that activates human tissue plasminogen (t-PA). It is a glycoprotein of molecular mass 68,000 that is synthesized by vascular endothelial cells. t-PA cells were first isolated from cultured human melanoma cells [56-58], but currently a genetically recombined form of rt-PA is genetically engineered. 

Ohmori T, Arteaga C]L (1998) Protein kinase C epsilon translocation and phosphorylation by cis-diamminedichloroplatinum(II) (CDDP) potential role in CDDP-mediated cytotoxicity. Cell Growth Differ 9 345-353 Ojeda F, Guarda MI, Maldonado C, Folch H, Diehl H (1992) Role of protein kinase-C in thymocyte apoptosis induced by irradiation. Int J Radiat Biol 61 663-667 Oka M, Ogita K, Ando H, Horikawa T, Hayashibe K, Saito N, Kikkawa U, Ichihashi M (1996) Deletion of specific protein tdnase C subspecies in human melanoma cells. J Cell Physiol 167 406-412... 

A2058 MM96L All DIO Melanoma Melanospheres high levels of reciprocal (not co-expressed) BRN2 or MITE More similar to human melanomas in situ, in 2-D, molecules were co-expressed (110)... 

E.K. Rofstad, T. Danlelsen, Hypoxia-Induced metastasis of human melanoma cells Involvement of vascular endothelial growth factor-mediated angiogenesis, Br. J. Cancer 80 (1999) 1697-1707. 

Casagrande, F. and Darbon, J.M., Effects of structurally related flavonoids on cell cycle progression of human melanoma cells regulation of cyclin-dependent kinases CDK2 and CDKl, Biochem. Pharmacol, 61, 1205, 2001. 

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