Allergenic activity

Ohta, M., Matsuura, F., Kobayashi, Y., Shigeta, S., Ono, K., and Oka, S., Further characterization of allergenically active oligosaccharitols isolated from a sea squirt H-antigen, Arch. Biochem. Biophys., 290, 474, 1991. 

Van Och, F.M. et al., Assessment of potency of allergenic activity of low molecular weight compounds based on IL-1 alpha and IL-18 production by a murine and human keratinocyte cell line, Toxicology, 210, 95, 2005. 

Humphreys, N.E., Dearman, R.J., and Kimber, I., Assessment of cumulative allergen-activated lymph node cell proliferation using flow cytometry, Toxicol Sci., 73, 80, 2003. 

Bodin, A., et al., Identification and allergenic activity of hydroxyaldehydes — anew type of oxidation product from an ethoxylated non-ionic surfactant, Contact Dermatitis, 44, 207, 2001. 

It will be apparent from this brief survey that both the models in which most investment has been made show promise, and each offer certain advantages. In both cases there is a need for further investment in research to develop a clearer and more confident understanding of how best these methods can be integrated effectively with other information relating to allergenic activity to provide a holistic assessment of likely sensitizing potential. 

PHARMACOLOGICAL ACTIVITIES AND CLINICAL TRIALS Allergenic activity. Oleoresin powder, administered externally to adults, was active. Reactions to patch test occurred most commonly in patients who were regularly exposed to the substance, or who already had dermatitis on the fingertips. Previously unexposed patients had few reactions (i.e., no irritant reactions... 

Allergenic activity. Cigarette smoke condensate, in cell culture at concentrations of 6.6-20 Ig/mL, produced an inhibition of... 

Allergenic activity. Fiber of the dried seed, administered orally to female adults, was active. Total serum immunoglobulin (Ig) E was elevated in a 40-year-old woman with allergic cutaneous and respiratory symptoms associated with chronic psyllium ingestion . Dried seedcoat, administered orally to adults, was active. A 60-year-old female suffered an anaphylactic reaction after ingestion of a psyllium-containing cereal f Skin prick result from psyllium powder and specific IgE antibodies were positive in a 31-year-old atopic woman who... 

Anti-allergenic activity. Hot water extract of the of the dried rhizome, administered by gastric intubation to mice at a dose of 100 mg/kg, was inactive vs type IV reaction with contact dermatitis induced by picryl chloride and type I reaction induced by antidinitrophenylated ascaris-IgE serum in 48 hours homologous PCA in rats. Dosing... 

As it is still uncertain, whether these efforts will finally result in a conclusive animal model to predict food allergy in humans, it is anticipated that the information that finally can be obtained from animal models will have to be evaluated in concert with other parameters related to the potential allergenic activity of the protein/food, in order to assess if the protein/food might have a low or high allergenic potential in humans. 

Urisu, A., Ando, H., Morita, Y., Wada, E., Yasaki, T., Yamada, K., Komada, K., Torii, S., Goto, M., Wakamatsu, T. 1997. Allergenic activity of heated and ovomucoid-depleted egg white. J Allergy Clin Immunol 100 171-176. 

Hansen, T. K., Skov, S. P, Poulsen, L. K., and Bindslev-Jensen, C. 1994. Allergenic activity of processed fish. Allergy Clin Immunol News Suppl 2 445. 

Hansen, K.S., Ballmer-Weber, B.K., Ltittkopf, D. et al. 2003. Roasted hazelnuts-allergenic activity evaluated by double-blind, placebo-controlled food challenge. Allergy 58 132-138. 

Lauer, I., Foetisch, K., Kolarich, D. et al. 2004. Hazelnut (Corylus avellana) vicilin Cor a 11 Molecular characterization of a glycoprotein and its allergenic activity. Biochem J 383 327-334. 

Armentia, A., Sanchez-Monge, R., Gomez, L., Barber, D., Salcedo, G. 1993. In vivo allergenic activities of eleven purified members of a major allergen family from wheat and barley flour. Clin Exp Allergy 23 410-415. 

In a type 1 or humoral hypersensitivity response, the allergen activates the B lymphocyte. Immunoglobulin E (IgE) is produced and binds to the surface of mast cells and basophils, causing them to become sensitized (Figure 13-1). 

A literature search could not reveal any publications about a possible allergenic activity of Stevia plants, dried leaves or stevioside itself Kinghom came to the same conclusions no published reports have appeared that would suggest that extracts of Stevia leaves are immunologically active when taken internally [36]. Similarly there is no evidence that any of the constituents of Stevia caused allergic contact dermatitis. 

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