Human gamma interferon

Beldarrain, A., J.L. Lopez-Lacomba, G. Furrazola, D. Barberia, and M. Cortijo. 1999. Thermal denaturation of human gamma-interferon. A calorimetric and spectroscopic study. Biochemistry 38 7865-7873. 

Fig. 1.10 (A) Positive mode electrospray spectrum of human gamma interferon on a quadrupole mass analyzer. (B) Deconvoluted spectrum of human gamma interferon. The molecular mass was measured at 16908 2 Da.

The oval object in this photograph is a bacterium genetically engineered to produce human gamma interferon. (CNRI/Photo Researchers, Inc.)... 

Ault BH, Stapleton FB, Gaber L, Martin A, Roy S, 3rd, Murphy SB Acute renal failure during therapy with recombinant human gamma interferon, N Engl J Med 1988,319 1397-1400... 

Mori, M., et ah, Efficient production of human gamma interferon in tobacco protoplasts by genetically engineered brome mosaic vims RNAs. J Gen Virol, 1993 74 (Pt 7) 1255-1260. 

An intermediate stage in the purification of human gamma interferon from tissue culture using cation-exchange is shown in Fig. 

Ye, J., Cippitelli, M., Dorman, L., Ortaldo, J.R., and Young, H.A. (1996a). The nuclear factor yyl suppresses the human gamma interferon promoter through two mechanisms Inhibition of apl binding and activation of a silencer element. Mol. Cell. Biol. 16,4744—4753. 

Berton, G., Zeni, L., Cassatella, M. A., Rossi, F. (1986). Gamma interferon is able to enhance the oxidative metabolism of human neutrophils. Biochem. Biophys. Res. Commun. 138,1276-82. 

ChuE, Zinn S. Boarman D, et al. Interaction of gamma interferon and 5-fluorouracil in the H630 human colon carinoma cell line. Cancer Res 1990 50 5834-5840. 

Interferon gamma is an activator of macrophages. Its anti-viral activity is limited compared to that of interferon alfa. Human recombinant interferon gamma restores, at least in part, macrophage cytotoxicity and with that decreases the incidence of infections in patients with chronic granulomatous diseases. Its adverse effects consist mainly of flu-like syndrome skin rashes may occur. 

Wallach, D., M. Fellous, and M. Revel, Preferential effect of gamma interferon on the synthesis of HLA antigens and their mRNAs in human cells. Nature, 1982. 299(5886) 833-6. 

Kleinerman, E.S., R. Kurzrock, D. Wyatt, J.R. Quesada, J.U. Gutterman, and I.J. Fidler, Activation or suppression of the tumoricidal properties of monocytes from cancer patients following treatment with human recombinant gamma- interferon. Cancer Res, 1986. 46(10) 5401-5. 

Strutz F, Heeg M, Kochsiek T, Siemers G, Zeisberg M, Muller GA. Effects of pentoxifylline, pentifylline and gamma-interferon on proliferation, differentiation, and matrix synthesis of human renal fibroblasts. Nephrology Dialysis Transplantation 2000, 15, 1535-1546. 

Zhang, H.M., Yuan, J., Cheung, P., Chau, D., Wong, B.W., McManus, B.M., and Yang, D. (2005). Gamma interferon-inducible protein 10 induces HeLa cell apoptosis through a p53-dependent pathway initiated by suppression of human papillomavirus type 18 E6 and E7 expression. Mol Cell Biol 25, 6247-6258. 

Human recombinant interferon gamma-lb multiple targets within the lymphokine regulatory network... 

Biopharmaceuticals that are industrially produced by microbial (bacterial or yeast) fermentation include insulin, human growth hormone, hepatitis B surface antigen vaccine, alpha interferon, beta interferon, gamma interferon, granulocyte colony stimulating factor, and interleukin-2. Table 30.8 lists some of the major biopharma products, some of which are produced by mammalian cell culture. 

Fig. 2 ICAM-1 production after topical application of gamma interferon to a human skin graft on nude mice. One dose (100 pi) of a liposomal (20mg/ml lipid) or aqueous (phosphate buffered saline) formulation was applied daily for three days. Active formulation contained 0.51 mg/ml gamma interferon. Placebo liposomal formulations contained no added protein. Significant differences (active versus placebo) are indicated by asterisks ( ). (Redrawn from data in Ref. l)...

Seitz M, Franke M, Kirchner H. Induction of antmuclear antibodies in patients with rheumatoid arthritis receiving treatment with human recombinant interferon gamma. Ann Rheum Dis 1988 47(8) 642-4. 

Gifibrd, G.E. and Lohmann-Matthess, M.L. (1987). Gamma interferon priming of mouse and human macroph es for induction of tumor necrosis fector production by bacterial lipopolysaccharide. J. Natl. Cancer Inst. 78, 121-124. 

Fantuzzi L, Gessani S, Borghi P, et al. Induction of interleukin-12 IL-12) by recombinant glycoprotein gpl20 of human immunodeficiency virus type 1 in human monocytes/macrophages Requirement of gamma interferon for IL-12 secretion. 

SuUivan CM, Smith DM, Matsui NM, et al. Identification of constitutive and gamma-interferon- and interleukin 4-regulated proteins in the human renal carcinoma ceE line ACHN. Cancer Res 1997 57 1137-43. 

Yong, V. W., Tejada-Berges, T., Goodyer, G. G., Antel, J. R, and Yong, F. R, Differential proliferative response of human and mouse astrocytes to gamma-interferon, Glia, 6, 269, 1992. 

Saiki L, Sone S, Fogler WE, et al. Synergism between human recombinant gamma-interferon and muramyl dipeptide encapsulated in liposomes for activation of antitumor properties in human blood monocytes. Cancer Res 1985 45 6188-6193. 

Denz, H., Lechleitner, M., Marth, C., Daxenbichler, G., Gastl, G., and Braun-steiner, H., Effect of human recombinant alpha-2- and gamma-interferon on the growth of human cell lines from solid tumors and hematologic malignancies, /. Interferon Res, 5, 147, 1985. 

Yoong, K. F., S. C. Afford, R. Jones, P. Aujla, S. Qin, K. Price, S. G. Hubscher, and D. H. Adams. 1999. Expression and function of CXC and CC chemokines in human malignant liver tumors a role for human monokine induced by gamma-interferon in lymphocyte recruitment to hepatocellular carcinoma. Hepatology 30 100. 

Arya SK, Wong-Staal F, Gallo RC. Dexamethasone-mediated inhibition of human T cell growth factor and gamma-interferon messenger RNA. J Immunol 1984 133 272-276. 

Rothenfusser, S., V. Hornung, A. Krug, A. Towarowski, A.M. Krieg, S. Endres, and G. Hartmann (2001) Distinct CpG oligonucleotide sequences activate human gamma delta T cells via interferon-alpha/-beta. Eur J Immund 31 3525-3534. 

Germany interferon, gamma interferon Polyferon Immuneron Recombinant human interferon gamma Anti-inflam- matory... 

A7. Aggarwal, B. B., Eessalu, T. E., and Hass, P. E. Characterization of receptors for human tumor necrosis factor and their regulation by gamma-interferon. Nature (London) 318, 665-667 (1985). 

M4. Magielska Zero, D., Bereta, J., Czuba Pelech, B., Pajdak, W., Gauldie, J., and Koj, A. Inhibitory effect of human recombinant interferon gamma on synthesis of acute phase proteins in human hepatoma Hep G2 cells stimulated by leukocyte cytokines, TNF alpha and IFN-beta 2/BSF-2/IL-6. Biochem. Int. 17, 17-23 (1988). 

Adib-Conquy, M., and Cavaillon, J. M. Gamma interferon and granulocyte/monocyte colony-stimulating factor prevent endotoxin tolerance in human monocytes by promoting interleukin-1 receptor-associated kinase expression and its association to MyD88 and not by modulating TLR4 expression. J Biol Chem 277 (2002) 27927-27934. 

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