Hormone analog

The many hormone analogs prepared in the 10(54)uZ)eo-estr-4(10)-ene-3,5-dione and the 10(54i H)uZ)eo-androstane-3,5-dione series clearly demonstrates that a wide range of functional groups may be safely carried through these synthetic sequences or that the resulting products have the requisite functionality for further structural elaboration. 

In the preparation of C-nor-D-homosteroid hormone analogs Mitsuhashi and Harada extended the Bamford-Stevens rearrangement to the cholanic acid series. Treatment of 3a-hydroxy-12-oxocholanic acid /j-toluene-... 

Gonadotropin releasing hormone analogs (goserelin, buserelin, leuprorelin, triptorelin) inhibit gonadotropin release and thus lower testosterone or estrogen levels. They are used to treat breast cancer and prostate cancer. 

The use of polylactides for delivery of insect hormone analogs and other veterinary compounds (115,116) has been studied. Microspheres, pellets, and reservoir devices based on polyglycolide, poly-(DL-Iactide), poly(L-lactide), and various copolymers have been used to deliver methoprene and a number of juvenile hormone analogs. ... 

Diabetes mellitus Gonadotropin-releasing hormone analogs (e.g.,... 

Abou-Samra, A.B., Freeman, M., Juppner, H., Uneno, S., and Segre, G.V. (1990) Characterization of fully active biotinylated parathyroid hormone analogs. Applications to fluorescence activated cell sorting of parathyroid hormone receptor bearing cells./. Biol. Chem. 265, 58-62. 

Analogs of juvenile hormones found in plants include the juvoclmenes in Ocimum basillcum, juvablone in Abies balsamea, and farnesol in many plant oils (lA). These natural plant products have never been used commercially as a source of insecticides, but they have served as model compounds for the development of synthetic juvenile hormone analogs such as kinoprene and methoprene (Figure 5). 

While the above observation is interesting and could possibly have some implications for the control of the pink bollworm, the complexity of the steroid nucleus of ponasterone A and other molting hormone analogs and their weak insecticidal effect when applied topically or administered orally to most species of economically important insects may preclude their commercialization. The only commercial use of the molting hormone analogs thus far has been in the sericultural industry for the synchronization of cocoon spinning of silkworm colonies (17). 

In an effort to overcome some of these difficulties and to provide the beginnings of a rational approach to the design of hormone analogs, we have utilized conformational and topographical restriction of peptide hormone and neurotransmitter structures. In this approach, we have attempted to make use where possible of classical structure-function studies, to Interpret the results from these studies In terms of specific conformational parameters which may be Involved In the observed rela-... 

Chemical Class Gonadotropin-releasing hormone analog Clinical Pharmacology ... 

It is to be expected that these extremely widely used oral methods of contraception will eventually be replaced by luteinizing hormone analogs as antiovulatory agents, or possibly by immunological methods directed against human chorionic gonadotrophin (hCG), which has both LH and FSH activity. Prostaglandins also show promise, and reliable male contraception is also a future possibility. 

Semisynthetic heterocycles are also important dmg molecules. These compounds attempt to capture the best of both worlds, being synthetic derivatives of natural products. The use of a natural product in the preliminary stages of the synthesis enables the elimination of numerous costly synthetic steps. The subsequent synthetic modifications enable further fine tuning of the natural product pharmacophore. There are a number of semisynthetic penicillin derivatives available. Similarly, there are also semisynthetic hormone analogs, especially of estrogens and gestagens. 

Antidiuretic hormone analogs desmopressin acetate vasopressin... 

Hormone analogs that bind specifically to a receptor and initiate the signal transduction pathway in the same maimer as the genuine hormone are termed agonists. Application in research and medicine is foimd especially for those agonists which posses a higher affinity for a receptor than the imderivatized hormone. 

Tonini G, Marioni S, Forleo V, Rustico M. Local reactions to luteinizing hormone releasing hormone analog therapy. J Pediatr 1995 126 159-60. 

Unal O, Berberoglu M, Evliyaoglu O, Adiyaman P, Aycan Z, Ocal G. Effects of bone mineral density of gonadotropin releasing hormone analogs used in the treatment of central precocious puberty. J Pediatr Endocrinol Metab 2003 16 407-11. 

Colson AO, Gershengorn MC. Thyrotropin-releasing hormone analogs. Mini Rev Med Chem. 2006 6 221-226. 

S. Hirai,T. Yashiki, and H. Mima. 1982. Vaginal absorption of a potent luteinizing hormone-releasing hormone analog (leuprolide) in rats I absorption by various routes and absorption enhancement./. Pharm. Sci. 71 1367—1371. 

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