Thyroid hormone analog

Mousa SA, O Connor L, Davis FB, et al, Proangiogenesis action of the thyroid hormone analog 3,5-diiodothyropropi-onic acid (DITPA) is initiated at the cell surface and is integrin mediated, Endocrinology 2006 147 1602-1607,... 

Leeson PD, Emmet JC, Shah VP, Showell GA, Novelli R, Prain HD, et al. Selective thyromimetics Cardiac-sparing thyroid hormone analogs containing 3 -aryl-methyl substituents. J Med Chem 1989 32 320-36. 

Absolute Configuration ofthe Thyroid Hormone Analog KAT-2003 I 317... 

As described above, the absolute configuration of the chiral thyroid hormone analog KAT-2003 (-t-)-9 was unambiguously determined as S by the H NMR anisotropy method using novel MaNP acid (S)-(-i-)-3. This result indicates that MaNP method is very powerful for determining the absolute configurations of chiral synthetic drugs. 

In the following decades, various a scales were derived for different systems and several attempts were made to derive such relationships also for biological activities of organic compounds. Bruice et al. [10] formulated group contributions to biological activity values in a series of thyroid hormone analogs, which may be considered as a first Free-Wilson-type analysis. Zahradnik and Chvapil [11] and Zahradnik [12,13] tried to apply the concept of the Hammett equation also to biological data (Eq. (5)) ... 

Absolute Configuration of the Thyroid Hormone Analog KAT-2003 as Determined by the NMR Anisotropy Method Using MaNP Acid... 

The chiral thyroid hormone analog KAT-2003 (- -)-122 has hypocholesterolemic activities and decreases hepatic... 

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