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Parathyroid hormone receptors

Abou-Samra, A.B., Freeman, M., Juppner, H., Uneno, S., and Segre, G.V. (1990) Characterization of fully active biotinylated parathyroid hormone analogs. Applications to fluorescence activated cell sorting of parathyroid hormone receptor bearing cells./. Biol. Chem. 265, 58-62. [Pg.1041]

Parathyroid hormone (PTH) regulates calcium levels in blood and bone remodeling. The activation domain of that 84-amino acid polypeptide locates around the N-terminal (1-34 amino acids). Parathyroid hormone receptor is a typical G-protein coupled receptor, which is coupled to both adenyl cyclase/cAMP and PLCy/IP3/cytosolic Ca2+ intracellular signaling pathways. In order to identify the structural elements involved in the peptide hormone binding and signal initiation, Chorev et al. employed a photoaffinity scanning approach. The N-terminal amino acids were successively deleted or modified and the new N-terminus was replaced for photoreactive Bpa. The most active peptide ana-... [Pg.190]

The mechanism of G a disease may resnlt from insnfficient parathyroid hormone-related peptide signaling by the parathyroid hormone receptor 1 (PTHRl) in chondrocytes. This deficiency may inhibit the differentiation of chondrocytes within the endochondral growth plate (88,89). A variety of parathyroid hormone abnormalities can result. [Pg.85]

Parathyroid Hormone Receptor Mutations and Skeletal Dysplasias... [Pg.119]

The parathyroid hormone receptor 1 (PTHRl) protein belongs to the GPCR family B. The PTHRl is a receptor for PTH and for parathyroid hormone-related peptide... [Pg.119]

Sheikh, S. P., Vilardarga, J. P., Baranski, T. J., Lichtarge, O., Iiri, T., Meng, E. C., Nissenson, R. A., and Bourne, H. R. (1999). Similar structures and shared switch mechanisms of the beta2-adrenoceptor and the parathyroid hormone receptor. Zn(II) bridges between helices III and VI block activation. J. Biol. Chem. 274, 17033-17041. [Pg.165]

Castro, M., Nikolaev, V. O., Palm, D., Lohse, M. J., and Vilardaga, J. P. (2005). Turn-on switch in parathyroid hormone receptor by a two-step PTH binding mechanism. Proc. Natl. Acad. Sci. USA 102, 16084-16089. [Pg.186]

Chauvin, S., M. Bencsik,T. Bambino, and R.A. Nissenson. 2002. Parathyroid hormone receptor recycling role of receptor dephosphorylation and beta-arrestin. Mol. Endocrinol. 16 2720-2732. [Pg.324]

F. L. Tobin. 2005. Response to continuous and pulsatile PTH dosing a mathematical model for parathyroid hormone receptor kinetics. Bone 37 159-169. [Pg.324]

Gs, alpha (GNAS) 20ql3.2 Insertions/deletions and SNPs, 20 % in exon 7 Haploinsufficiency Albright s hereditary osteodystrophy (AHO), short stature, obesity, brachydactyly, subcutaneous ossifications, developmental deficits Inactivating Gas variants lead to variable phenotype related to insufficient parathyroid hormone receptor (PTHR1) in chondrocytes [96-99]... [Pg.131]

Parathyroid hormone receptor (PTHR1) H223R, T410P, I458R... [Pg.157]

Parathyroid Hormone Receptor, Skeletal Dysplasias, and Primary Failure of Tooth Eruption... [Pg.166]

A second member of the parathyroid hormone family, parathyroid hormone-related protein (PTHrP), is quite similar to PTH in amino acid sequence and protein structure. Like PTH, it activates the parathyroid hormone receptor causing increased bone resorption and renal tubular calcium reabsorption. Increased serum concentrations of parathyroid hormone-related protein are the predominant cause of hypercalcemia in cancer patients with solid tumors. This observation led to its discovery and to the elucidation of its many cellular functions in normal tissues. In contrast to PTH, which is expressed only in parathyroid glands, PTHrP is detected in many tissues in fetuses and adults it is found in epithelia, mesenchymal tissues, endocrine glands, and the central nervous system. This protein is also the principal regulator of placental calcium transport to the fetus. [Pg.887]

Growth Hormone-releasing Hormone Receptoi Parathyroid Hormone Receptor Parathyroid Hormone Receptor 1 Parathyroid Hormone Receptor 2... [Pg.190]

These two hormones, together with the vitamin calcitriol, regulate calciumhomeostasis and thereby indirectly affect phosphate metabolism. Parathyroid hormone (parathormone PTH) is secreted by the parathyroid glands as a polypeptide of 84 amino acid residues, and its action is to increase plasma calcium via parathyroid hormone receptors in bone, kidney, and a few other tissues. PTH secretion is increased in response to hypocalcemia and hyperphosphatemia conversely, increased plasma calcium suppresses PTH secretion. The renal production of 1,25-dihydroxycholecalciferol is also... [Pg.120]

Gesty-Palmer D, Chen M, Reiter E, Ahn S, Nelson CD, Wang S, Eckhardt AE, Cowan CL, Spumey RE, Luttrell LM, Lefkowitz RJ (2006) Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERKl/2 activation. J Biol Chem 281 (16) 10856-10864... [Pg.62]

See other pages where Parathyroid hormone receptors is mentioned: [Pg.1129]    [Pg.87]    [Pg.744]    [Pg.72]    [Pg.452]    [Pg.153]    [Pg.166]    [Pg.53]    [Pg.336]    [Pg.951]    [Pg.186]    [Pg.202]    [Pg.724]    [Pg.144]    [Pg.52]    [Pg.224]   
See also in sourсe #XX -- [ Pg.180 , Pg.181 ]

See also in sourсe #XX -- [ Pg.286 ]

See also in sourсe #XX -- [ Pg.72 ]



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