Pituitary hormone analogs

The drags listed in Table 37-2 are pituitary hormone analogs or agents used for their effects on pituitary-related endocrine function. Many of the natural hormones described in Table 37-1 are also used as drags. 

Table 37-2. Pituitary hormone analogs or agents used for their effects on pituitary-related endocrine function.

At present, pituitary hormones—and potent antagonist analogs of GnRH—are receiving increased attention. A GnRH antagonist in combination with testosterone has been shown to produce reversible azoospermia in nonhuman primates. 

Hypothalamic and pituitary hormones (and their synthetic analogs) have pharmacologic applications in three areas (1) as replacement therapy for hormone deficiency states (2) as drug therapy and (3) as diagnostic tools for performing stimulation tests. 

Thyrotropin is an anterior pituitary hormone that stimulates the thyroid to produce and synthesize thyroxine (T4), triiodothyronine (T3), and thyroglobulin. Thyrotropin alpha is a commercially available analog of TSH that is used to help detection of metastatic differentiated thyroid carcinoma it is also known as recombinant human TSH (rhTSH). 

GnRH and its analogs (nafarelin, buserelin, etc) have become important in both stimulating and inhibiting ovarian function. They are discussed in Chapter 37 Hypothalamic Pituitary Hormones. 

Central diabetes insipidus A synthetic analog of the natural pituitary hormone 8-arginine vasopressin Lactose, potato starch, povidone, magnesium stearate Aventis... 

The method of testing in vitro on dispersed pituitary cells is essentially a static method for the comparison of hormones and hormone analogs. It has also been applied to the testing and pituitary tissue ex vivo, from animals that have undergone a period of treatment with compounds that are known to modify the pituitary response, e.g. synthetic corticoids. 

Desmopressin Antidiuretic hormone analog Pituitary diabetes insipidus A Vj receptor agonist longer-acting than vasopressin (ADH)... 

Nemeroff CB, Bissette G, Martin JB, et al Effect of chronic treatment with thyrotropin-releasing hormone (TRH) or an analog of TRH (hnear-beta-alanine TRH) on the hypothalamic-pituitary-thyroid axis. Neuroendocrinology 30 193-199, 1980... 

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