Hepatocellular chemoembolization

A 37-year-old woman with refractory idiopathic thrombocytopenic purpura, who had responded dramatically to danazol 600 mg/day after the failure of other forms of treatment, developed a multinodular well-differentiated trabeculovesicular hepatocellular tumor after 5 years. There were no metastases and no invasion of the lymph nodes, and after chemoembolization she received an orthoptic liver transplant. A year later she remained in good condition. [Pg.166]

Sumi, S., Yamashita, Y., Mitsuzaki, K., Yamamoto, H., Urata, J., Nishi-haru, T., Takahashi, M. Power Doppler Sonography assessment of tumor recurrence after chemoembolization therapy for hepatocellular carcinoma. Amer. J. Roentgenol. 1999 172 67—71... [Pg.140]

Farinati, F., de Maria, N., Marafin, C., Herszenyi, L., dei Prato, St., Rinaldi, M., Perini, L., Cardin, R., Naccarato, R. Unresectable hepatocellular carcinoma in cirrhosis. Survival, prognostic factors, and unexpected side effects after transcatheter arterial chemoembolization. Dig. Dis. Sci. 1996 41 2332-2339... [Pg.803]

Pacell C.M., Bizzari, G., Cecconi, R, Caspani, B., Magnolfi, F., BiancUni, A., Anelli, V., Pacella, S., Rossi, Z. Hepatocellular carcinoma long-term results of combined treatment with laser thermal ablation and transcatheter arterial chemoembolization. Radiology 2001 219 669-678... [Pg.804]

In an open trial, percutaneous ethanol injections into the liver improved prognosis compared with conservative treatment in 63 patients with cirrhosis and hepatocellular carcinoma who were not suitable for surgery or transcatheter arterial chemoembolization (16). Most of the patients had mild to moderate local pain during or immediately after injection and 29% developed fever. [Pg.1286]

Kato T, Saito Y, Niwa M, Ishiguro J, Ogoshi K. Combination therapy of transcatheter chemoembolization and percutaneous ethanol injection therapy for imresectable hepatocellular carcinoma. Cancer Chemother Pharmacol 1994 33(Suppl) S115-18. [Pg.1286]

Horiguchi Y, Honda T, Fujii S, Matsushima S, and Osaki Y. A Case of Allergic Contact Dermatitis from Propylene Alycol in an Ultrasonic Gel, Sensitized at a Leakage Skin Injury Due to Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma. Int J Dermatol Z005 44 681-683. [Pg.424]

Hepatocellular carcinoma (HCC) represents one of the most common types of cancer, with more than 1 million new cases worldwide and a dramatic increase in the western world. In most cases, HCC is detected at an advanced stage and frequently liver cirrhosis as an underlying disease is present. Therefore, therapeutic options are limited. Beside resection, liver transplantation is regarded the only curative therapy [4]. However, only 10%-15% of patients are candidates for curative surgery - especially due to the shortage of liver donors. There are no effective systemic treatments [4] to date for these patients and transarterial chemoembolization or RE are therefore the only palliative therapies. [Pg.11]

The appropriate examination technique is critical for sensitive detection and specific characterization of focal liver lesions. A biphasic examination of the liver with a late-arterial and a portal venous phase can be regarded as standard today. For specific indications, like the follow-up of hepatocellular carcinoma (HCC) after transarterial chemoembolization (TACE) or for the depiction of the arterial vessels prior to angiography, an early arterial phase scan, which can be post-processed into CT angiography, is helpful (Fig. 3.2). The value of delayed scans (e.g. 5 min after contrast agent injection) is controversial in the literature mainly centers with a focus on imaging in liver cirrhosis consider the use of late phase images as necessary, whereas other authors see no added value for it [21,45]. [Pg.17]

Fig. 3.8. Male patient suffering from a multifocal hepatocellular carcinoma (HCC), treated with repeated sessions of transarterial chemoembolization (TACE). Dyna-CT (Siemens Medical Solutions, Erlangen, Germany) image started together with injection of 10 ml iodinated contrast agent via a super-selective catheter system placed in the right hepatic artery compared with a corresponding MDCT section in the arterial phase after i.v. injection of 120 ml iodinated contrast agent. Note the excellent, direct depiction of arterial blood supply of the HCC nodule in liver segment 5/8 (arrow). The artifacts in the left and right liver lobe are caused by spots of Lipiodol in already treated HCC nodules after earlier transarterial chemoembolization...

Guan YS, Zheng XH, Zhou XP et al (2004) Multidetector CT in evaluating blood supply of hepatocellular carcinoma after transcatheter arterial chemoembolization. World J Gastroenterol 10 2127-2129... [Pg.26]

Ueno K, Miyazono N, Inoue H, Miyake S, Nishida H, Nakajo M (1995) Embolization of the hepatic falciform artery to prevent supraumbilical skin rash during transcatheter arterial chemoembolization for hepatocellular carcinoma. Cardiovasc Intervent Radiol 18 183-185... [Pg.42]

Miyayama S, Matsui O, Taki K et al (2006) Extrahepatic blood supply to hepatocellular carcinoma angiographic demonstration and transcatheter arterial chemoembolization. Cardiovasc Intervent Radiol 29 39-48... [Pg.42]

Chung JW, Kim HC, Yoon JH et al (2006) Transcatheter arterial chemoembolization of hepatocellular carcinoma prevalence and causative factors of extrahepatic collateral arteries in 479 patients. Korean J Radiol 7 257-266... [Pg.42]

Chung JW, Park JH, Han JK, Choi BI, Kim TK, Han MC (1998) Transcatheter oily chemoembolization of the inferior phrenic artery in hepatocellular carcinoma the safety and potential therapeutic role. J Vase Interv Radiol 9 495-500... [Pg.42]

Huo TI, Wu JC, Lee PC et al (2004) Incidence and risk factors for acute renal failure in patients with hepatocellular carcinoma undergoing transarterial chemoembolization a prospective study. Liver Int 24 210-215... [Pg.115]

Grieco A, Marcoccia S, Miele L et al (2003) Transarterial chemoembolization (TACE) for unresectable hepatocellular carcinoma in cirrhotics functional hepatic reserve and survival. Hepatogastroenterology 50 207-212... [Pg.115]

Kim HC, Cheng JW, Lee W, Jae HJ, Park JH (2005) Recognizing extrahepatic collateral vessels that supply hepatocellular carcinoma to avid complications of transcatheter arterial chemoembolization. Radiographics 25 S25-S39... [Pg.146]

Kim HK, Cheng YH, Song BC et al (2001) Ischemic bile duct injury as a serious complication after transarterial chemoembolization in patients with hepatocellular carcinoma. I Clin Gastroenterol 32 423-427... [Pg.146]

Kabayashi S, Nakamura Y, Terada T et al (1993) Postmortem survey of bile duct necrosis and biloma in hepatocellular carcinoma alter transcatheter arterial chemoembolization therapy relevant to microvascular damages of peribiliary capillary plexus. Am J Gastroenterol 88 1410-1415... [Pg.146]

Lee KH, Sung KB, Lee DY, Park SJ, Kim KW, Yu JS (2002) Transcatheter arterial chemoembolization for hepatocellular carcinoma anatomic and hemodynamic considerations in the hepatic artery and portal vein. Radiographics 22 1077-1091... [Pg.13]

Fig. 9.4a-c. Hepatocellular carcinoma (HCC), chemoembolization CDDP, Adria/Gelfoam. a Common hepatic arteriography. Note the hypervascularity of this hepatic neoplasm (HCC). b Status post chemoembolization of the right hepatic artery note the speckled gas within the neoplasm due to air introduced during the embolization, tissue necrosis or both, c Reduction in the size of the defect as seen 2 years later... [Pg.191]

Caturelli E et al. (2000) Transcatheter arterial chemoemboliza-tion for hepatocellular carcinoma in patients with cirrhosis evaluation of damage to nontumorous liver tissue-longterm prospective study. Radiology 215 123-128 Cauldwell EW et al. (1948) The bronchial arteries. An anatomic study of 150 human cadavers. Surg Gynecol Obstet 86 395 Charnsangavej C (1993) Chemoembolization of liver tumors. [Pg.220]

Chung JW et al. (1995) Hepatocellular carcinoma and portal vein invasion results of treatment with transcatheter oily chemoembolization. AJR Am J Roentgenol 165 315-321 Chung JW et al. (1996) Hepatic tumors predisposing factors for complications of transcatheter oily chemoembolization Radiology 198 33-40... [Pg.220]

Lehnert T, Herfarth C (1996) Chemoembolization for hepatocellular carcinoma. What, when, and for whom Ann Surg 224 1-3... [Pg.221]

Nakamura H et al. (1994) Five-year survival after transcatheter chemoembolization for hepatocellular carcinoma. Cancer Chemother Pharmacol 33[Suppl l] S89-92 Nakamura H et al. (1989) Transcatheter oily chemoembolization of hepatocellular carcinoma. Radiology 170(3 Pt 1) 783-786... [Pg.222]

Pajkos G et al. (1998) Combined therapy of metastatic liver neoplasms intrahepatic chemoembolization and systemic chemotherapy. Orv Hetil 139 1013-1017 Parkin DM et al. (1999) Estimates of the worldwide incidence of 25 major cancers in 1990. Int J Cancer 80 827-841 Patt YZ et al. (1994) Hepatic arterial infusion of floxuridine, leucovorin, doxorubicin, and cisplatin for hepatocellular carcinoma effects of hepatitis B and C viral infection on drug toxicity and patient survival. J Clin Oncol 12 1204-1211... [Pg.222]

Patton TJ Kavanagh JJ (1991) Five-year survival in patients given intra-arterial chemotherapy prior to radiotherapy for advanced squamous carcinoma of the cervix and vagina. Gynecol Oncol 42 54-59 Pelage JP et al. (1999) Arterial anatomy of the female genital tract variations and relevance to transcatheter embolization of the uterus. AJR Am J Roentgenol 172 989-994 Pelletier G et al. (1990) A randomized trial of hepatic arterial chemoembolization in patients with unresectable hepatocellular carcinoma. J Hepatol 11 181 184 Pentecost MJ et al. (1993) Hepatic chemoembolization safety with portal vein thrombosis. J Vase Interv Radiol 4 347 351... [Pg.222]

Solomon B et al. (1999) Chemoembolization of hepatocellular carcinoma with cisplatin, doxorubicin, mitomycin-C, ethiodol, and polyvinyl alcohol prospective evaluation of response and survival in a US population. J Vase Interv Radiol 10 793-798... [Pg.223]

Wright KC et al. (1986) Pulsed arterial infusions. Chemotherapeutic implications. Cancer 57 1952-1956 Yamada K et al. (1998) Direct duodenal invasion of hepatocellular carcinoma intestinal hemorrhage treated by transcatheter arterial embolization. Clin Imaging 22 196-199 Yamada R et al. (1995) Transcatheter arterial chemoembolization (TACE) in the treatment of unresectable liver cancer. World J Surg 19 795-800... [Pg.223]

Zhang Z et al. (2000) The effect of preoperative transcatheter hepatic arterial chemoembolization on disease-free survival after hepatectomy for hepatocellular carcinoma. Cancer 89 2606-2612... [Pg.224]

Hehnberger T, Dogan S, Straub G et al. (2007) Liver resection or combined chemoembolization and radiofrequency ablation improve survival in patients with hepatocellular carcinoma. Digestion 75 104-112... [Pg.558]

A 70-year-old Chinese woman had a gastric varix injected with enbucrilate plus hpiodol followed by transarterial chemoembolization for hepatocellular carcinoma, at which time radio-opaque lipiodol was noted in the gastric varix and in several branches of the right pulmonary artery [29 ]. [Pg.1014]

Table 2.5.2. Results of chemoembolization in hepatocellular cancer (literature review). (A, Adria Adriamycin, ADMOS doxorubicin+mitomycin+lipiodol, CDDP cisplatin, Collaghovine collagen, CTLS CDDP+pirarubicin, DSM degradable starch microspheres, Epi epirubicin, F 5-FU 5-fluorouracil, FUDR 5-fluorodeoxyuridine, Gel gelfoam, Lipi /ipiodol, M, Mito mitomycin, Mo months, N/A not available. Neuroend TM neuroendocrine tumors, PVA polyvinyl alcohol, STZ streptozotocin)...

Fig. 2.5.8. Selective hepatic arteriogram shows a hypervas-cular hepatocellular carcinoma (HCC) in the right lobe with transtumoral arterioportal shunting. Before starting the chemoembolization, embolization of these shunts is necessary to prevent serious side-effects...

Allgaier HP, Deibert P, Olschewski M, Spamer C, Blum U, Gerok W, Blum HE (1998) Survival benefit of patients with inoperable hepatocellular carcinoma treated by a combination of transarterial chemoembolization and percutaneous ethanol injection-a single-center analysis including 132 patients. Int J Cancer 79 601-605... [Pg.58]

Bianco S, Merkel C, Savastano S et al (1996) Short-term effects of transcatheter arterial chemoembolisation on metabolic activity of the liver of cirrhotic patients with hepatocellular carcinoma. Gut 39 325-329 Bismuth H, Morino M, Sherlock D, Castaing D, Miglietta C, Cauquil P, Roche A (1992) Primary treatment of hepatocellular carcinoma by arterial chemoembolization. Am J Surg 163 387-394... [Pg.59]

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