Liver resection

An earlier cross sectional study had found that the PME/PDE ratio was a measure of disease severity in chronic hepatitis-C. ° More recently, it was found that this ratio may also serve as a biomarker of response to treatment with antiviral therapy. ° Whereas non-responders had similar or even elevated PME/PDE initially, that ratio declined from 0.27 0.02 (standard error) to 0.16 0.01 after treatment (p<0.001) in responders. Liver resection is a common therapy for liver metastases. Prior portal vein embolization (PVE) of the resected lobe results in h) ertrophy of the remaining contralateral lobe. Phosphorus-31 MRSI has been used to monitor metabolism of the regenerating lobe after PVE. ° ... [Pg.143]

Linear PEI None Pol-III HI IV Partial liver resection Fisher rats Liver HGF Suppression of mRNA and protein, moderate suppression of hepatocyte proliferation (54)... [Pg.20]

Tc-DTPA Arterial perfusion accounts for 20%-40% of the circulation in portal hypertension, cirrhosis causes arterial perfusion to increase to over 60%. In portal vein thrombosis, only an arterial curve is visible. Liver metastasis usually displays relatively high arterial perfusion. In (rare) occlusions of the hepatic artery, only a portal venous curve is visible. When a bolus injection of 400 MBq "Tc-diethylenetriamine pentaacetic acid (DTPA) is applied, scintigraphy is able to reveal a bi-phasic time-activity curve. The initial increase of activity is produced by the arterial influence and the second peak by the portal venous inflow. Both curves can be evaluated quantitatively. (36) Perfusion scintigraphy may be useful in the case of liver trauma, TIPS, hyper-vascularized hepatic tumours and partial liver resection as well as after liver transplantation. [Pg.194]

Replication of hepatocytes in the form of excessive hyperplasia can occur occasionally after extensive parenchymal necrosis or partial liver resection. However, this does not generally cause a clinical discernible form of hepatomegaly. [Pg.210]

In the process of regeneration, irreversibly damaged or surgically removed liver tissue is replaced as far as possible by new growth. The regeneration of the liver (s. p. 5 ) is a most important process in (7.) overcoming necrosis, (2.) determining the course of a liver disease, (i.) liver resection, (4.) partial liver transplantation, and (5.) liver cell transplantation. (29)... [Pg.402]

DNA synthesis commences just 10 to 12 hours after partial liver resection, and after another 10 to 20 hours, mitotic division reaches maximum activity. Replication in the endothelial cells and bile duct epithelia follows within 1 to 3 days. Consequently, 3 or 4 weeks subse-... [Pg.402]

Que, F., Nagorney, D.M., Gross, J.B., Torres, V.E. Liver resection and cyst fenestration in the treatment of severe polycystic liver disease. Gastroenterology 1995 108 487 -494... [Pg.676]

Regeneration after liver resection follows a coordinated and limited course. This is not the case in cirrhosis isolated and excessive regenerations of hepatocytes and bile ducts are formed, from which adenomas and carcinomas may develop. [Pg.720]

Atypical liver resection, enucleation, local tumour excision... [Pg.766]

Bohm, B., Voth, M., Georghegan, J., Heitfritzsch, H., Petrovich, A., Scheeie, J., Gottschiid, D. Impact of positron emission tomography on strategy in liver resection for primary and secondary liver tumors. [Pg.802]

Micbel, J., Sue, B., Montpeyroux, Hachemanne, S., Blanc, P., Dom-ergue, X, Mouiel, J., Gouillat, C., Ducerf, C., Saric, J., Le Treut, Y.P., Fourtanier, G., Escat, J. Liver resection or transplantation for hepatocellular carcinoma Retrospective analysis of 215 patients with cirrhosis. J. Hepatol. 1997 26 1274-1280... [Pg.804]

Martinez Isia, A., Ferrara, A., Badia, J.M., Hoiioway, I., Tanaka, H., Riaz, A., Habib, N.A. Fibrolamellar hepatocellular carcinoma results of partial liver resection. Rev. Esp. Enf Digest. 1997 89 703-705... [Pg.806]

Yamamoto, J., Kosuge, T., SUmada, K., Yamasaki, S., Moriya, Y., Sngihara, K. Repeat liver resection for recurrent colorectal bver metastases. Amer. J. Surg. 1999 178 275 -281... [Pg.809]

Islet-cell injection Liver resection TIPS... [Pg.836]

The first liver resection in the form of a lobectomy was carried out on a dog by G. Zambeccari as early as 1680. The first resection in humans (removal of an adenoma) was also performed in Italy, but the outcome was fatal (A. Lius, 1886). The first successful resection of a large, benign, pedicled lobular constriction was carried out by c. v. Langenbuch (Germany) in 1888, while successful resections were performed in the USA by w.w. Keen as from 1892. [Pg.870]

Definition A liver resection is defined as the surgical removal of tissue components of the liver in order to eliminate a localized disease process. The left hepatic lobe (segment I-IV) contains 40% and the right lobe (segment V-VIII) contains 60% of the total liver mass. (s. fig. 40.4) Removal of > 80% of a healthy liver is (in principle) fatal. Hyperplasia of the remaining liver can be expected, while regeneration of the resected portion of the liver is also possible. [Pg.870]

A wide spectrum of focal lesions of varying sizes provides the indication for liver resection (323, 325, 328, 330, 331, 333, 337) ... [Pg.871]

Higashiguchi, T., Ito, A., Kitagawa, M., Taoka, H., Kawarada, Y. Administration of branched-chain amino acids prevents bacterial translocation after liver resection in the cirrhotic rat. Hepat. Bil. Pancr. Surg. 1996 3 291-296... [Pg.885]

Belghiti, J., Hiramatsu, K., Benoist, S., Massault, PR, Sauvanet, A., Farges, O. Seven hundred forty-seven hepatectomies in the 1990s an update to evaluate the actual risk of liver resection. J. Amer. Coll. Surg. 2000 191 38 - 46... [Pg.889]

Chouillard, E., Cherqui, D., Tayar, C., Brunetti, F., Fagniez, PL. Anatomical bi- and trisegmentectomies as alternatives to extensive liver resections. Arch. Surg. 2003 238 29-34... [Pg.889]

Knbo, S., NisUgnchl, S., Hamba, H., Hirohashi, K., Tanaka, H., Shuto, T., KlnosUta, H., Knroki, T. Reactivation of viral rephcation after liver resection in patients infected with hepatitis B virus. Ann. Surg. 2001 233 139-145... [Pg.889]

Standi, T. Burmeister, M-A. Horn, E-P. Wilhelm, S. Knoefel, W.T. Schulte am Esch, J. Bovine haemoglobin-based oxygen carrier for patients undergoing haemodilu-tion before liver resection. Brit. J. Anaesth 1998, 80, 189-194. [Pg.374]

Chouker A, Martignoni A, Schauer RJ, Dugas M, Schachtner T, Kaufmann I, Setzer F, Rau HG, Lohe F, Jauch KW, Peter K, Thiel M (2005) Alpha-glutathione S-transferase as an early marker of hepatic ischemia/ reperfusion injury after liver resection. World JSurg29(4) 528-534. doi 10.1007/s00268-004-7431-3... [Pg.473]

SEVERE Major cardiothoracic surgery Whipple procedure Liver resection Pancreatitis 100-150 mg of hydrocortisone (or 20-30 mg of methyl- prednisolone) IV on day of procedure Rapid taper over 1-2 days to usual replacement dose... [Pg.156]

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