Neoplasm hepatic

Liver and Gallbladder. High dosages of oral estrogens have been reported to increase the risk for jaundice, cholestatic hepatitis, gallstones, and hepatic vein blood clots. Estrogens promote the development of hepatic neoplasms associated with increased hepatic cell regenerative activity (186,187). 

Malins DC, MM Krahn, MS Myers, LD Rhodes, DW Brown, CA Krone, BB McCain, S-L Chan (1985) Toxic chemicals in sediments and biota from a creosote-polluted harbor relationships with hepatic neoplasms and other hepatic lesions in English sole (Parophrys vetulus). Carcinogenesis 6 1463-1469. 

Neoplasms of the liver have also been a prominent finding. In studies with beagles, hepatic neoplasms including hemangiosarcomas, fibrosarcomas, and fibromas were observed (Benjamin et al., 1973 1974 ... 

Exposed to approximately 4, 47, or 270 pg BaP/L tor 6 h, once weekly tor 2-4 weeks Hepatic neoplasms at intermediate and high concentration exposures 7,12-dimethylbenz[a]-anthracene was more potent than BaP, and medakas were more sensitive than guppies 26... 

Pritchard, M.K., J.W. Fournie, and V.S. Blazer. 1996. Hepatic neoplasms in wild common carp. Jour. Aquat. Anim. Health 8 111-119. 

Dawe, C.J., Stanton, M.F. and Schwartz, F.J. Hepatic neoplasms in native bottom-feeding fish of Deep Creek Lake, Maryland. Cancer Res. (196U) 2k, 119 -1201. 

Rats exposed to 207 ppm daily for 6 months developed hepatic neoplasms hepatocellular hyperplasia and necrosis occurred after 3 months of exposure at this concentration. In another series of inhalation experiments on rats, 200 ppm produced hepatocellular carcinomas in both sexes 100 ppm resulted in liver tumors in males after 12 months of exposure... 

Hepatotoxicity Prolonged use of high doses of androgens has been associated with the development of potentially life-threatening peliosis hepatis, hepatic neoplasms, and hepatocellular carcinoma. Cholestatic hepatitis and jaundice occur with fluoxymesterone and methyltestosterone at relatively low doses. Drug-induced jaundice is reversible when the medication is discontinued. 

Peliosis hepatitis (liver, spleen replaced with blood-filled cysts), hepatic neoplasms, and hepatocellular carcinoma have been associated with prolonged high dosage. 

Malins, D.C., Krahn, M.M., Brown, D.W., Rhodes, L.D., Myers, M.S., McCain, B.B., Chan, S.L. (1995). Toxic chemicals in marine sediment and biota from Muldlteo, Washington Relationships with hepatic neoplasms and other hepatic lesions in EngUsh sole Parophrys vetulus). JNatl Cancer Inst 74 487 94. 

Male Fischer 344 rats were fed 200 ppm 2-acetylaminofiuorene (AAF) for seven weeks to induce hepatocellular altered foci, and were subsequently fed 0 or 12 000 ppm di(2-ethylhexyl) phthalate (98% pure) in the diet. No evidence of induction of hepatocellular altered foci or hepatic neoplasms was found when di(2-ethylhexyl) phthalate was given alone for 24 weeks. Di(2-ethylhexyl) phthalate fed for 24 weeks increased basophilic foci, but showed no promoting effect on iron-excluding altered hepatic foci induced by AAF, and produced no significant enhancement of the occurrence of AAF-induced liver neoplasms (3/6 compared with 3/12) (Williams et al., 1987). 

Carbazole 9-oxyl 327 has been identified from its ESR spectrum in the livers of English sole with hepatic neoplasms it was also found in healthy fish after they had been injected with carbazole (85MI2) (see also Section III.F). 

Schuetz EG, Euruya KN, Schuetz JD. In ter individual variation in expression of P-glycoprotein in normal human liver and secondary hepatic neoplasms. J Pharmacol Exp Ther 1995 275 1011-8. 

PAH (DMBA + BaP) 30-250 Mg/1, 6 h Hepatic neoplasms (and extra hepatic DMBA only) 74... 

Myers, M.L., J.T. Landahl, M.M. Krahn and B.B. McCain. Relationships between hepatic neoplasms and related lesions and exposure to toxic chemicals in marine fish from the US West Coast. Environ. Health Perspect. 90 7-15, 1991. 

Peck-Miller, K.A., M. Myers, T. Collier and J.E. Stein. Complete cDNA sequence of the Ki-ras protooncogene in the liver of wild English sole (Pleuronectes vetulus) and mutation analysis of hepatic neoplasms and other toxicopathic liver lesions. Mol. Carcinog. 23 207-216, 1998. 

Vincent-Hubert, F. cDNA cloning and expression of two Ki-ras genes in the flounder, Platichthys flesus, and analysis of hepatic neoplasms. Comp. Biochem. Physiol. 126C 17-27, 2000. 

Vogelbein, W.K., J.W. Fournie, P.A. Van Veld and R.J. Huggett. Hepatic neoplasms in the mummichog Fundulus heteroclitus from a creosote-contaminated site. Cancer Res. 50 5978-5986, 1990. 

Exposure of bottom-dwelling fish to concentrations of PAHs in contaminated sediments in Puget Sound, Washington and the incidence of disease including hepatic neoplasms (Malins et al. 1984). This is discussed, with emphases on karien flatfish by de Maagd and Vethaak (1998). 

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