Hepatitis jaundice

Isoniazid is bactericidal against growing M. tuberculosis. Its mechanism of action remains unclear. (In the bacterium it is converted to isonicotinic acid, which is membrane impermeable, hence likely to accumulate intracellu-larly.) Isoniazid is rapidly absorbed after oral administration. In the liver, it is inactivated by acetylation, the rate of which is genetically controlled and shows a characteristic distribution in different ethnic groups (fast vs. slow acetylators). Notable adverse effects are peripheral neuropathy, optic neuritis preventable by administration of vitamin Be (pyridoxine) hepatitis, jaundice. 

Enhanced anticoagulant effects Endogenous factors that may be responsible for increased PT/INR response include the following Blood dyscrasias cancer collagen vascular disease CHF diarrhea elevated temperature hepatic disorders (eg, infectious hepatitis, jaundice) hyperthyroidism poor nutritional state steatorrhea vitamin K deficiency. 

NSAIDs. Hematopoietic side effects (e.g., leukopenia, hemolytic anemia, aplastic anemia, purpura, thrombocytopenia, and agranulocytosis) also may occur. Ocular effects (blurred vision, corneal deposits) have been observed in patients receiving indomethacin, and regular ophthalmological examinations are necessary when the drug is used for long periods. Hepatitis, jaundice, pancreatitis, and hypersensitivity reactions also have been noted. 

GI hemorrhage, cholestatic hepatic jaundice, leukopenia, thrombocytopenia, pan cytopenia, agranulocytosis, and aplastic or hemolytic anemia occur rarely. 

More serious conditions for which people take herbal drugs include depression, irregular heartbeat and other heart problems, arthritis, arteriosclerosis (hardening of the arteries), asthma, high blood pressure, various cancers, diabetes, epilepsy, gallstones, sexually transmitted diseases, hepatitis, jaundice, malaria, measles, obesity, tetanus, tuberculosis, and ulcers. 

It is not advisable for people with a history of hepatitis, jaundice, or other serious liver disease to take [these] lysergic acid amides. Because several of the alkaloids in this family of sacraments have powerful uterus-stimulating properties we recommend that they not be taken by pregnant women. 

Idiosyncratic toxicity Metabolic abnormality No No Weeks-months Any Increased liver enzymes, hepatitis, jaundice Diclofenac Ketoconazole... 

Tachycardia, growth suppression, palpitations, transient loss of weight, increased hyperactivity, dyskinetic movements (face, bps, tongue), hepatitis, jaundice Life-threatening Exfoliative dermatitis, uremia, thrombocytopenia... 

Note A hypersensitivity reaction - termed the sulfone syndrome or dapsone syndrome - may infrequently develop during the first six weeks of treatment. This syndrome consists of exfoliative dermatitis, fever, malaise, nausea, anorexia, hepatitis, jaundice, lymphadenopathy and hemolytic anemia. See (1982) Kromann NP +, Arch Dermatol I 18, 531... 

Failure to meet age-appropriate developmental milestones Hepatic Jaundice Hepatomegaly... 

Ethionamide, which has bacteriostatic actions against M. tuberculosis (0.5 to 1 g/day in divided doses) is indicated in the treatment of tuberculosis where first-line drugs such as isoniazid and rifampin have failed. The side effects of ethionamide may include nausea and vomiting, diarrhea, metallic taste, hepatitis, jaundice, stomatitis, depression, drowsiness, asthenia, peripheral neuritis, olfactory disturbances, diplopia, blurred vision, optic neuritis, convulsions, postural hypotension, thrombocytopenia, gynecomastia, impotence, menorrhagia, or diabetes mellitus. 

Cardiac illness, elderly, glaucoma, history of hepatitis/jaundice, seizure disorder, hypotension, suicidal... 

Congenital Familial Nonhemolytic Jaundice Hemolytic Anemia Obstructive Jaundice Hepatic Jaundice... 

Jaundice may develop by three different mechanisms hemolytic jaundice results from the overproduction of bile pigments obstructive jaundice develops because of a block in the excretion mechanism and hepatic jaundice is due to impairment of the hepatic secretion of bile. 

Dicamba 15-40 50 250 Mild hepatic jaundice, no other health effects... 

Traditional Medicine. In Chinese folk medicine, a decoction of the whole aboveground herb is used for treatment of colds, sunstroke, tonsillitis, pleurisy, urinary tract infections, infectious hepatitis, jaundice, and dysentery as an antidote for arsenic poisoning, poisoning by Gelsemium elegans, and toxic mushrooms external poultice for snakebites, scabies, traumatic injuries, and herpes zoster (uangsu). 

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