Jaundice Hepatic

Chronic hepatitis (disease lasting longer than 6 months) is usually associated with hepatitis B, C, and D. Chronic viral hepatitis may lead to the development of cirrhosis, which may induce end-stage liver disease (ESLD). Complications of ESLD include ascites, edema, jaundice, hepatic encephalopathy, infections, and bleeding esophageal varices. Therefore, prevention and treatment of viral hepatitis may prevent ESLD. 

Hypersensitivity Fever, skin eruptions of various types, including exfoliative dermatitis, infectious mononucleosis-like, or lymphoma-like syndrome, leukopenia, agranulocytosis, thrombocytopenia, Coombs positive hemolytic anemia, jaundice, hepatitis, pericarditis, hypoglycemia, optic neuritis, encephalopathy, Leoffler s syndrome, vasculitis, and a reduction in prothrombin. 

Hepatotoxicity Severe hepatic reactions, including acute liver failure, jaundice, hepatitis, and cholestasis, have been reported rarely in postmarketing data in patients receiving infliximab. Autoimmune hepatitis has been diagnosed in some of... 

Adverse effects occur in 3-12% in the form of rash, fever, urticaria, vasculitis, arthralgia, a lupuslike reaction, cholestatic jaundice, hepatitis, lym-phadenopathy and polyserositis but the most dangerous adverse effect is agranulocytosis (it occurs only in 0.3-0.6%). The reaction is readily reversible when the drug is discontinued. Cross-sensitivity between propylthiouracil and methimazole is about 50%, therefore switching drugs in patients with severe reactions is not recommended. 

Abnormal hepatic function, including jaundice, hepatitis, and hepatic necrosis alopecia anaphylaxis breast enlargement erythema multiforme peripheral edema and seizures have been reported. 

Hepatotoxicity (abnormal liver function test results, jaundice, hepatitis), hemolytic anemia, unexplained fever, and flu-like symptoms may occur. If these conditions appear, discontinue the medication and contact the physician. 

Hepatotoxicity (e.g., jaundice, hepatitis, hepatic failure, acute renal failure) has been observed in severely ill patients. 

Patients with liver disease may exhibit an increased sensitivity of many drugs. Patients with obstructive jaundice, hepatitis, cirrhosis shows reduce ability to synthesize glucuronide and sulfate conjugates. 

Adverse reactions to the thioamides occur in 3-12% of treated patients. Most reactions occur early. The most common adverse effect is a maculopapular pruritic rash, at times accompanied by systemic signs such as fever. Rare adverse effects include an urticarial rash, vasculitis, arthralgia, a lupus-like reaction, cholestatic jaundice, hepatitis, lymphadenopathy, hypoprothrombinemia, exfoliative dermatitis, polyserositis, and acute arthralgia. 

To some extent in prescriptions for jaundice, hepatic torpor and skin diseases. Is also sometimes included in pile ointments. The 1 ounce to 1 pint infusion is taken in doses of 2 fl. ounces. 

Adverse effects in patients include anorexia, nausea, vomiting, gastrointestinal ulceration, skin eruptions, bone marrow depression, reversible cholestatic jaundice, hepatic necrosis, dermatitis, and drug fever.2 LD50 (i.p., mouse) 157 mg/kg (i.p., hamster) 364 mg/kg.1... 

A 16-year-old woman consumed ecstasy and developed jaundice, hepatic failure, a prothrombin ratio of 9, and grade I encephalopathy. She had a liver transplant and was asymptomatic at 11 months. 

As CHCs and POCs are metabohsed by the liver their use may adversely affect this patient, who has severely compromised liver function. CHC or POC methods should not be advocated in this case. This patient s synthetic and metabohc function is significantly impaired and therefore the metabohsm of CHCs could be affected, precipitating adverse drug reactions such as jaundice, hepatitis and cholestasis. 

Gastrointestinal and hepatic Gastritis, dyspepsia, dysphagia, colitis, anorexia, hematemesis, pancreatitis, ascites, jaundice, hepatitis... 

Four post-marketing reports of hepatic failure have been reported one patient with multiple myeloma developed severe jaundice, hepatic failure, and coma, and died 1 month after the start of thalidomide therapy three other patients had pre-existing liver disease, and hepatic failure and death were probably not drug-related (21). 

In obstructive jaundice, cholestatic jaundice, hepatitis, and cirrhosis there is an increased excretion of predominantly coproporphyrin-I, because liver disease causes a diversion of the secretion of coproporphyrin-I from the biliary to the renal route. ... 

The root of the plant Cryptolepis sanguinolenta (Lindl.) Schlt (Periplocaceae) is used in traditional African medicine to treat a variety of diseases including malaria, jaundice, hepatitis, urinary tract infections, hypertension, inflammatory conditions and stomach ache. Extracts of the roots are also used as a tonic often taken daily for years without evidence of toxicity. Various studies indicate that the crude extracts as well as the isolated alkaloidal constituents of the plant possess a number of interesting pharmacological properties. The focus of this overview is to highlight the potential of Cryptolepis sanguinolenta in modem health care. 

ACUTE HEALTH RISKS abdominal pain nausea vomiting cough fever chills anorexia rigidity weakness may cause effects on the liver jaundice hepatitis myocardial damage irritation of skin and eyes. 

Optic neuritis, fever, pruritis, headache, nausea, anorexia, dermatitis, hypersensitivity, p chic disturbances Peripheral neuropathy, nausea, vomiting, epigastric distress, jaundice, hepatitis, pyridoxine deficiency, skin eruptions, hypersensitivity... 

Acetaminophen Mild anorexia, nausea, vomiting, delayed jaundice, hepatic and renal failure... 

Traditional use The seeds are used to treat jaundice, hepatitis, chronic coughing and hemoptysis, gall-stones and inflammation of the gall bladder and bile duct, liver and spleen diseases, fevers, hemorrhoids, and other diseases. Juice from the leaves is drunk as a choleretic and diuretic and to treat colitis and constipation. A decoction of the root is drunk to treat stomach catarrh. Currently, an alcohol-water extraction of the seeds is used to treat liver diseases (Khalmatov 1964 Khodzhimatov 1989). 

Lack of bile salts Obstructive jaundice Hepatic insufficiency Cirrhosis Hepatitis... 

Congenital Familial Nonhemolytic Jaundice Hemolytic Anemia Obstructive Jaundice Hepatic Jaundice... 

Cholestatic jaundice, hepatic steatosis and siderosis Hyperammonemia not obligate... 

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