Heart rate body temperature effects

The study will commence with the administration of low doses, as judged from the non-clinical data. As the study progresses - and provided that there are no indications that it is unsafe to do so - the dosage levels may be increased past the anticipated therapeutic range. Subjects are closely monitored for changes in vital signs (blood pressure, heart rate, body temperature, etc.) and the emergence of any adverse side effects (nausea, drowsiness, pain, headache, irritability, hair loss, etc.). 

The most common side effect of pentazocine is sedation resulting from an interaction with the K-receptor. Also observed are sweating, dizziness, psychotomimetic effects, anxiety, nightmares, and headache. Nausea and vomiting are less frequent than with morphine. Respiratory depression and increased heart rate, body temperature, and blood pressure accompany overdose. Naloxone is effective in reducing the respiratory depression but requires the use of higher doses than for morphine overdose. 

Adverse effects of high-dose MDMA intoxication, including cardiovascular stimulation and elevated body temperature, are thought to involve monoamine release from sympathetic nerves in the periphery or nerve terminals in the CNS.48 MDMA increases heart rate and mean arterial... 

Initial safety tests were carried out in beagle dogs and subsequently in cynomolgus monkeys. Single bolus i.v. doses of up to 100 mg kg-1 were used and were found to exert no negative effect upon general condition, blood pressure, heart or cardiovascular parameters, respiration rate or body temperature. No safety tests evaluating potential product effects upon the central nervous system were undertaken, as the protein is considered unlikely to cross the blood-brain barrier. 

Effects on blood pressure, heart rate, lead II ECG, core body temperature, and locomotor activity can be explored using DataSciences telemetry implanted devices in rats, guinea-pigs, dogs, or primates. Effects on behavior can be captured on video using CCTV for dog and primate studies. Repeated administration and interaction studies can be performed. 

Heightened sensory perceptions Stimulates appetite Perceived slower passage of time Panic or anxiety Dissociative symptoms Physiological Effects Increases heart rate Reduces body temperature Slowed gastrointestinal function Electrophysiology... 

THC produces dose-dependent increases in heart rate and reductions in body temperature after injection, maximizing after 2 to 3 hours (table 10.6) (Heishman et al. 1989). Similarly, anandamide creates hypothermia in mice after injection (Pride and Mechoulam 1993). The cognitive effects of THC are dissociable from the autonomic effects (Bachman et al. 1979). 

The physiological effects include an increase in blood pressure and body temperature, nystagmus, slurred speech, ataxia, blurred vision, excessive sweating and salivation, fast heart rate, nausea, vomiting, and extraordinary strength. Deaths have been recorded from heart or respiratory failure. 

Valproate has antiepileptic efficacy in different types of epilepsy. It is therefore sometimes called the hroad range antiepileptic drug. It has no significant hypnosedative effects nor does it have respiratory depressant activity. In addition it does not have undesirable effects on blood pressure, heart rate, kidney function and body temperature. 

Effects on brain centers controlling movement may be experienced as muscle stiffness, tremor or uncontrollable shaking, jaw clenching, and nervous tics. Like amphetamine, piperazines produce increases in heart rate, blood pressure, and body temperature, which can be dangerous or even fatal. At high doses, piperazines may produce hallucinations, seizures or convulsions, and respiratory depression that can cause death. 

Overdose is usually characterized by an extremely elevated body temperature, heart rate, and blood pressure. Combining ecstasy with other drugs may or may not be intentional, since the true contents of an ecstasy tablet or capsule are rarely known to the user. For example, PMA, sold with or in place of MDMA as ecstasy, takes nearly four times longer than MDMA to take effect therefore the user might take extra doses thinking the original was not adequate. Multiple doses, coupled... 

Ecstasy use is associated with physiological damage to a number of body systems. These include the heart, brain, liver, kidneys, and the body s ability to regulate temperature. Ecstasy increases heart rate and blood pressure, which is especially dangerous for someone with a known or unknown heart condition, but can also cause an irregular heartbeat in an ordinarily healthy person. An irregular heartbeat means the heart pumps less effectively therefore the blood flow to the brain and other organs is not adequate. This condition increases the risk for heart attack, stroke, and other types of heart failure. 

Through its action on the dopamine and serotonin neurons in the brain, methamphetamine can cause paranoia, hallucinations, and severe mood disturbances. Methampethamine can also cause stroke through an increase in blood pressure, along with seizures. Other commonly seen side effects include irregular heart rate, damage to small blood vessels in the brain and eyes, and hyperthermia, which is an unregulated increase in the body s temperature. 

The actions of Salvia divinorum on the physiology of the body have not been studied as of 2002 and are thus unknown. However, other hallucinogenic substances have substantial effects on the autonomic nervous system, the part of the nervous system that governs bodily functions. These effects may include dilation of the pupils, blurred vision, tremors, uncoordination, elevated heart rate, heart palpitations, elevated body temperature, and sweating. 

The use of tobacco is addictive. Most users develop tolerance for nicotine and need greater amounts to produce a desired effect. Smokers become physically and psychologically dependent and will suffer withdrawal symptoms including changes in body temperature, heart rate, digestion, muscle tone, and appetite. 

Activation of CB receptors by phytocannabinoids such as THC can cause a multitude of effects such as euphoria, anxiety, altered time perception, loss of concentration, and panic attacks. The most commonly researched ones are feeling of well-being, euphoria, and relaxation. THC produces an increase in heart rate, blood pressure, and body temperature (dose-dependent effects). It is also possible to experience dry mouth, increased hunger, and pain reduction. Very high doses of cannabis can cause anxiety, panic, or result in psychotic episodes. 

Cocaine is a CNS stimulant that affects blood vessels and pupils, and increases body temperature, heart rate, and blood pressure. The euphoric effects of cocaine are quick and include reduced fatigue and mental clarity, as well as hyperstimulation. Research reports that the faster the absorption, the shorter the duration of action. The effects of cocaine in humans are variable (e.g., feeling of restlessness, irritability, and anxiety). Cocaine has powerful neuropsychological-reinforcing properties that are responsible for its repeated compulsive use. In some cases, the first dose may prove fatal. Cocaine-related death may be due to cardiac arrest or convulsion followed by respiratory arrest. In drug abuse, people mix cocaine with alcohol, leading to a chemical complex called cocaethylene, which intensifies the euphoria but can culminate in death. 

Adverse effects of cocaine include constricted peripheral blood vessels, dilated pupils, and increased body temperature, heart rate, and blood pressure. Cocaine induces several immediate euphoric effects, such as hyperstimulation, reduced fatigue, and mental clarity, all of which depend on the administration route. The faster the absorption of cocaine, the more severe the effects. In contrast, faster absorption limits the duration of action. For example, the effect from snorting cocaine may last 15 to 30 minutes, whereas effects from smoking may last 5 to 10 minutes. Increased use can reduce the period of stimulation, as addicted humans may develop tolerance. In rare instances, sudden death may occur on the first use of cocaine or unexpectedly thereafter. 

Interestingly, LSD is available in well-decorated absorbent paper and dispersed as small squares, facilitating its abuse by children and adults. The average dose is approximately 20 to 80 ig higher dose limits are 100 to 200 xg. The effect of LSD depends on the amount of intake effects appear within 30 to 90 minutes. Adverse effects include mydriasis, increased body temperature, blood pressure, and heart rate, loss of appetite, sleeplessness, dry mouth, sweating, and body tremors. 

Because the monkey is the most sensitive species for the effects on complement, we have opted to perform cardiovascular safety studies as part of subchronic study protocols using implanted telemetry units in selected monkeys (two/sex in at least two different treatment groups, including the high dose) to measure ECG, mean arterial pressure, heart rate, and body temperature. These parameters are then recorded at frequent intervals for a 24-hour period prior to treatment to establish circadian fluctuations and normal response to various stimuli encountered during the day. This technique enables us to assess both acute alterations related to complement activation after single doses and chronic safety after repeated administration. 

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